NP_001139281.1
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NCBI GenBank Nucleotide #
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UniProt Primary Accession #
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UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
227,871 Da
NCBI Official Full Name
myosin-14 isoform 3
NCBI Official Synonym Full Names
myosin, heavy chain 14, non-muscle
NCBI Official Synonym Symbols
DFNA4; MHC16; MYH17; PNMHH; DFNA4A; myosin; FP17425; NMHC II-C; NMHC-II-C [Similar Products]
NCBI Protein Information
myosin-14; MYH14 variant protein; myosin, heavy polypeptide 14; non-muscle myosin heavy chain IIc; nonmuscle myosin heavy chain II-C; myosin heavy chain, non-muscle IIc
UniProt Protein Name
Myosin-14
UniProt Synonym Protein Names
Myosin heavy chain 14; Myosin heavy chain, non-muscle IIc; Non-muscle myosin heavy chain IIc
UniProt Synonym Gene Names
UniProt Entry Name
MYH14_HUMAN
NCBI Summary for MYH10
This gene encodes a member of the myosin superfamily. The protein represents a conventional non-muscle myosin; it should not be confused with the unconventional myosin-14 (MYO14). Myosins are actin-dependent motor proteins with diverse functions including regulation of cytokinesis, cell motility, and cell polarity. Mutations in this gene result in one form of autosomal dominant hearing impairment. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2011]
UniProt Comments for MYH10
MYH14: Cellular myosin that appears to play a role in cytokinesis, cell shape, and specialized functions such as secretion and capping. Myosin is a hexameric protein that consists of 2 heavy chain subunits (MHC), 2 alkali light chain subunits (MLC) and 2 regulatory light chain subunits (MLC-2). High levels of expression are found in small intestine, colon and skeletal muscle. Expression is low in organs composed mainly of smooth muscle, such as aorta, uterus and urinary bladder. No detectable expression is found in thymus, spleen, placenta and lymphocytes. 5 isoforms of the human protein are produced by alternative splicing.
Protein type: Motility/polarity/chemotaxis; Motor
Chromosomal Location of Human Ortholog: 19q13.33
Cellular Component: growth cone; membrane; myosin II complex; axon; cytoplasm; stress fiber; actomyosin
Molecular Function: actin filament binding; microfilament motor activity; calmodulin binding; actin-dependent ATPase activity; ATP binding
Biological Process: skeletal muscle contraction; regulation of cell shape; axon guidance; skeletal muscle development; sensory perception of sound; actin filament-based movement; metabolic process; actomyosin structure organization and biogenesis; generation of action potential; ephrin receptor signaling pathway
Disease: Peripheral Neuropathy, Myopathy, Hoarseness, And Hearing Loss; Deafness, Autosomal Dominant 4a
Research Articles on MYH10
Precautions
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Pathways associated with MYH10 elisa kit
Organs/Tissues associated with MYH10 elisa kit
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