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NAE1 cdna clone

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Catalog # MBS1270405
Unit / Price
  0.01 mg Plasmid + 0.2 mL Glycerol-Stock  /  $165 +1 FREE 8GB USB
NAE1 cdna clone
Product Name

NAE1, cDNA Clone

Popular Item
Full Product Name

NAE1 cDNA Clone

Product Gene Name
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
Sequence
atggcgcagc tgggaaagct gctcaaggag cagaagtacg accggcagct gaggttgtgg ggtgatcatg ggcaagaggc tttagaatct gctcatgttt gcctaataaa tgcaacagcc acaggaactg aaattcttaa aaacttggta ctaccaggta ttggttcgtt tacaattatt gatggaaatc aggtcagcgg agaagatgct ggaaacaatt tcttccttca aagaagcagt atcggcaaga accgagctga agctgccatg gaattcttac aagaattaaa tagcgatgtc tctggaagtt ttgtggaaga gagtccagaa aaccttctag acaatgatcc ctcatttttc tgtaggttta ctgttgtagt tgcaactcag cttcctgaaa gcacttcact acgcttagca gatgtcctct ggaattccca gattcctctt ttgatctgta ggacatatgg actagttggt tatatgagga tcattataaa agaacatcca gtaatagaat ctcatccaga taatgcatta gaggatctac gactagataa gccatttcct gaactgagag aacattttca gtcctatgat ttggatcata tggaaaaaaa ggaccacagt catactccat ggattgtgat catagctaaa tatttagcac agtggtatag tgaaacaaat ggacgaatac ctaaaacgta taaagaaaaa gaggacttca gagatttgat tagacaagga attctaaaaa atgaaaatgg ggctccagaa gatgaagaga attttgaaga agctattaaa aatgtgaaca cagcactaaa tacaactcag atcccaagca gtattgaaga tatatttaat gatgatcgct gcataaatat caccaaacag actccatcat tttggatttt agctcgtgcc ttaaaggaat ttgtggccaa agagggtcaa ggaaatttac ctgttcgagg cacaattcct gatatgattg cagattcagg caaatatata aaactgcaaa acgtttaccg tgaaaaagca aagaaagatg ctgccgctgt gggtaatcat gttgccaaat tgctgcagtc cattggccag gcaccagagt ccatttcaga gaaagaatta aaattactct gcagcaattc tgcatttctt cgagtggtaa gatgtcgatc cttagctgaa gaatatggtt tggatacaat taacaaggat gaaattattt ctagcatgga caatccagat aatgaaatag tgttgtactt aatgttacgg gctgttgata gatttcataa acaacagggt agatatccag gagtatctaa ctatcaagtt gaagaagata taggaaagtt gaagtcttgt ctcactggct tccttcagga atatggttta tctgtaatgg tgaaagatga ttatgtccac gaattttgcc gatatggagc tgctgagcca cataccattg ctgcattctt ggggggagct gctgctcaag aggtcatcaa aataatcacc aaacaatttg taatttttaa taatacttac atttacagtg gcatgtcaca aacttcagca actttccagt tgtag
OMIM
603385
Vector
pENTR223.1
Clone Sequence Report
Provided with product shipment
ISO Certification
Manufactured in an ISO 9001:2008 Certified Laboratory.
Other Notes
Small volumes of NAE1 cdna clone vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
NCBI/Uniprot data below describe general gene information for NAE1. It may not necessarily be applicable to this product.
NCBI GI #
NCBI GeneID
NCBI Accession #
UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
60,517 Da
NCBI Official Full Name
Homo sapiens NEDD8 activating enzyme E1 subunit 1, mRNA
NCBI Official Synonym Full Names
NEDD8 activating enzyme E1 subunit 1
NCBI Official Symbol
NCBI Official Synonym Symbols
HPP1; ula-1; APPBP1; A-116A10.1
  [Similar Products]
NCBI Protein Information
NEDD8-activating enzyme E1 regulatory subunit
UniProt Protein Name
NEDD8-activating enzyme E1 regulatory subunit
UniProt Synonym Protein Names
Amyloid beta precursor protein-binding protein 1, 59 kDa; APP-BP1; Amyloid protein-binding protein 1; Proto-oncogene protein 1
UniProt Gene Name
UniProt Synonym Gene Names
APPBP1; APP-BP1  [Similar Products]
UniProt Entry Name
ULA1_HUMAN
NCBI Summary for NAE1
The protein encoded by this gene binds to the beta-amyloid precursor protein. Beta-amyloid precursor protein is a cell surface protein with signal-transducing properties, and it is thought to play a role in the pathogenesis of Alzheimer's disease. In addition, the encoded protein can form a heterodimer with UBE1C and bind and activate NEDD8, a ubiquitin-like protein. This protein is required for cell cycle progression through the S/M checkpoint. Three transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
UniProt Comments for NAE1
APPBP1: Regulatory subunit of the dimeric UBA3-NAE1 E1 enzyme. E1 activates NEDD8 by first adenylating its C-terminal glycine residue with ATP, thereafter linking this residue to the side chain of the catalytic cysteine, yielding a NEDD8-UBA3 thioester and free AMP. E1 finally transfers NEDD8 to the catalytic cysteine of UBE2M. Necessary for cell cycle progression through the S-M checkpoint. Overexpression of NAE1 causes apoptosis through deregulation of NEDD8 conjugation. Belongs to the ubiquitin-activating E1 family. ULA1 subfamily. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Ubiquitin conjugating system

Chromosomal Location of Human Ortholog: 16q22

Cellular Component: cytoplasm; cytosol; nucleus

Molecular Function: NEDD8 activating enzyme activity; protein binding; protein heterodimerization activity; ubiquitin protein ligase binding

Biological Process: mitotic cell cycle DNA replication checkpoint; neuron apoptosis; protein neddylation; regulation of apoptosis; regulation of neuron apoptosis; signal transduction
Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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