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Troponin T Native Protein

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Catalog # MBS355496
Unit / Price
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  0.1 mg  /  $325 +1 FREE 8GB USB
Troponin T native protein
Product Name

Troponin T, Native Protein

Popular Item
Full Product Name

Cardiac Troponin T Protein (Active)

Product Synonym Names
Troponin T, cardiac muscle, TnTc, Cardiac muscle Troponin T, cTnT, TNNT2
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
Host
Human heart tissue
Form/Format
Liquid
Concentration
2 mg/ml (lot specific)
Storage Buffer
Each vial contains Tris buffer (pH 7.5) without preservative.
Preparation and Storage
Ship at 4 degree C. Upon receipt, aliquot and store at -20 degree C or -80 degree C for long term.
Avoid repeated freeze and thaw cycles.
Other Notes
Small volumes of Troponin T native protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Related Product Information for
Troponin T native protein
Purified human cardiac Troponin T protein.

Background: Troponin T is one of 3 subunits that form the troponin complex of the thin filaments of striated muscle, the others are troponin I and troponin C. Troponin T was discovered by the German physician Hugo A. Katus. It binds to tropomyosin and helps position it on actin And in a less complicated light, Troponin T modulates contraction of striated muscle. In patients with stable coronary artery disease, troponin T concentrations have been found to be significantly associated with the incidence of cardiovascular death and heart failure, but not with myocardial infarction.
Applications Tested/Suitable for Troponin T native protein
ELISA (EIA)
Application Notes for Troponin T native protein
Other applications have not been tested.
NCBI/Uniprot data below describe general gene information for Troponin T. It may not necessarily be applicable to this product.
NCBI GI #
NCBI Accession #
NCBI Official Full Name
troponin T, partial
Protein Family
NCBI Summary for Troponin T
The protein encoded by this gene is the tropomyosin-binding subunit of the troponin complex, which is located on the thin filament of striated muscles and regulates muscle contraction in response to alterations in intracellular calcium ion concentration. Mutations in this gene have been associated with familial hypertrophic cardiomyopathy as well as with dilated cardiomyopathy. Transcripts for this gene undergo alternative splicing that results in many tissue-specific isoforms, however, the full-length nature of some of these variants has not yet been determined. [provided by RefSeq, Jul 2008]
UniProt Comments for Troponin T
TNNT2: Troponin T is the tropomyosin-binding subunit of troponin, the thin filament regulatory complex which confers calcium-sensitivity to striated muscle actomyosin ATPase activity. Heart. The fetal heart shows a greater expression in the atrium than in the ventricle, while the adult heart shows a greater expression in the ventricle than in the atrium. Isoform 6 predominates in normal adult heart. Isoforms 1, 7 and 8 are expressed in fetal heart. Isoform 7 is also expressed in failing adult heart. Belongs to the troponin T family. 11 isoforms of the human protein are produced by alternative splicing.

Protein type: Motor; Motility/polarity/chemotaxis

Chromosomal Location of Human Ortholog: 1q32

Cellular Component: sarcomere; troponin complex; cytosol; striated muscle thin filament

Molecular Function: troponin C binding; structural constituent of cytoskeleton; troponin I binding; ATPase activity; tropomyosin binding; actin binding

Biological Process: positive regulation of ATPase activity; regulation of muscle contraction; metabolic process; atrial cardiac muscle morphogenesis; ventricular cardiac muscle morphogenesis; sarcomere organization; response to calcium ion; negative regulation of ATPase activity; regulation of heart contraction; muscle filament sliding

Disease: Cardiomyopathy, Familial Restrictive, 3; Cardiomyopathy, Dilated, 1d; Cardiomyopathy, Familial Hypertrophic, 2
Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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