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NCK1 blocking peptide

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Catalog # MBS9220140
Unit / Price
  0.1 mg  /  $155 +1 FREE 8GB USB
NCK1 blocking peptide
Product Name

NCK1, Blocking Peptide

Also Known As

NCK1 Antibody (N-term) Blocking peptide

Product Synonym Names
Cytoplasmic protein NCK1; NCK adaptor protein 1; Nck-1; SH2/SH3 adaptor protein NCK-alpha; NCK1; NCK
Product Synonym Gene Name
Antibody/Peptide Pairs
NCK1 peptide (MBS9220140) is used for blocking the activity of NCK1 antibody (MBS9214889)
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
Sequence Length
377
OMIM
600508
3D Structure
ModBase 3D Structure for P16333
Specificity
The synthetic peptide sequence used to generate the antibody was selected from the N-term region of NCK1. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.
Form/Format
Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.
Cellular Location
Cytoplasm. Endoplasmic reticulum. Nucleus. Note: Mostly cytoplasmic, but shuttles between the cytoplasm and the nucleus. Import into the nucleus requires the interaction with SOCS7. Predominantly nuclear following genotoxic stresses, such as UV irradiation, hydroxyurea or mitomycin C treatments
Preparation and Storage
Maintain refrigerated at 2-8 degree C for up to 6 months. For long term storage store at -20 degree C.
Other Notes
Small volumes of NCK1 blocking peptide vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Related Product Information for
NCK1 blocking peptide
Adapter protein which associates with tyrosine- phosphorylated growth factor receptors, such as KDR and PDGFRB, or their cellular substrates. Maintains low levels of EIF2S1 phosphorylation by promoting its dephosphorylation by PP1. Plays a role in the DNA damage response, not in the detection of the damage by ATM/ATR, but for efficient activation of downstream effectors, such as that of CHEK2. Plays a role in ELK1-dependent transcriptional activation in response to activated Ras signaling. Modulates the activation of EIF2AK2/PKR by dsRNA. May play a role in cell adhesion and migration through interaction with ephrin receptors.
NCBI/Uniprot data below describe general gene information for NCK1. It may not necessarily be applicable to this product.
NCBI GI #
NCBI GeneID
NCBI Accession #
UniProt Primary Accession #
UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
35,511 Da
NCBI Official Full Name
Cytoplasmic protein NCK1
NCBI Official Synonym Full Names
NCK adaptor protein 1
NCBI Official Symbol
NCBI Official Synonym Symbols
NCK; nck-1; NCKalpha
  [Similar Products]
NCBI Protein Information
cytoplasmic protein NCK1
UniProt Protein Name
Cytoplasmic protein NCK1
UniProt Synonym Protein Names
NCK adaptor protein 1; Nck-1; SH2/SH3 adaptor protein NCK-alpha
Protein Family
UniProt Gene Name
UniProt Synonym Gene Names
NCK; Nck-1  [Similar Products]
UniProt Entry Name
NCK1_HUMAN
NCBI Summary for NCK1
The protein encoded by this gene is one of the signaling and transforming proteins containing Src homology 2 and 3 (SH2 and SH3) domains. It is located in the cytoplasm and is an adaptor protein involved in transducing signals from receptor tyrosine kinases to downstream signal recipients such as RAS. Alternatively spliced transcript variants encoding different isoforms have been found. [provided by RefSeq, Jun 2010]
UniProt Comments for NCK1
NCK1: adapter protein containing Src homology 2 and 3 (SH2 and SH3) domains. Transduces signals from tyrosine-phosphorylated growth factor receptors to their cellular substrates.

Protein type: Adaptor/scaffold; Motility/polarity/chemotaxis

Chromosomal Location of Human Ortholog: 3q21

Cellular Component: cytoplasm; cytosol; endoplasmic reticulum; plasma membrane; protein phosphatase type 1 complex; ribosome; trans-Golgi network

Molecular Function: ARF guanyl-nucleotide exchange factor activity; protein binding; protein binding, bridging; protein kinase inhibitor activity; receptor binding; receptor tyrosine kinase binding

Biological Process: negative regulation of peptidyl-serine phosphorylation; positive regulation of actin filament polymerization; positive regulation of T cell proliferation; positive regulation of transcription from RNA polymerase II promoter; T cell activation; T cell receptor signaling pathway; vascular endothelial growth factor receptor signaling pathway; vesicle-mediated transport
Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
Organs/Tissues associated with NCK1 blocking peptide
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