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NDRG1 peptide

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Catalog # MBS426596
Unit / Price
  0.1 mg  /  $190 +1 FREE 8GB USB
NDRG1 peptide
Product Name

NDRG1, Peptide

Also Known As

NDRG1 Immunizing Peptide

Product Synonym Names
NDRG1; N-myc downstream regulated gene 1; CAP43,; CMT4D; DRG1; GC4; HMSNL; NDR1; NMSL; PROXY1; RIT42; RTP; TARG1; TDD5; N-myc downstream regulated gene 1 protein; differentiation-related gene 1 protein; nickel-specific induction protein Cap43; protein reg
Product Gene Name
Antibody/Peptide Pairs
NDRG1 peptide (MBS426596) is used for blocking the activity of NDRG1 antibody (MBS420361)
Antibody/Peptide Pairs
NDRG1 peptide (MBS426596) is used for blocking the activity of NDRG1 antibody (MBS423562)
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
Sequence Length
394
Sequence
GNSAGPKSME VSC
OMIM
601455
Species Reactivity
Human, Mouse, Rat, Dog
Form/Format
100ug of dried peptide
Preparation and Storage
Shipped at ambient temperature, store at -20 degree C
ISO Certification
Manufactured in an ISO 9001:2015 Certified Laboratory.
Other Notes
Small volumes of NDRG1 peptide vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
NCBI/Uniprot data below describe general gene information for NDRG1. It may not necessarily be applicable to this product.
NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
33,650 Da
NCBI Official Full Name
protein NDRG1 isoform 1
NCBI Official Synonym Full Names
N-myc downstream regulated 1
NCBI Official Symbol
NDRG1  [Similar Products]
NCBI Official Synonym Symbols
GC4; RTP; DRG1; NDR1; NMSL; TDD5; CAP43; CMT4D; DRG-1; HMSNL; RIT42; TARG1; PROXY1
  [Similar Products]
NCBI Protein Information
protein NDRG1
UniProt Protein Name
Protein NDRG1
UniProt Synonym Protein Names
Differentiation-related gene 1 protein; DRG-1; N-myc downstream-regulated gene 1 protein; Nickel-specific induction protein Cap43; Reducing agents and tunicamycin-responsive protein; RTP; Rit42
Protein Family
UniProt Gene Name
NDRG1  [Similar Products]
UniProt Synonym Gene Names
CAP43; DRG1; RTP; DRG-1; RTP  [Similar Products]
UniProt Entry Name
NDRG1_HUMAN
NCBI Summary for NDRG1
This gene is a member of the N-myc downregulated gene family which belongs to the alpha/beta hydrolase superfamily. The protein encoded by this gene is a cytoplasmic protein involved in stress responses, hormone responses, cell growth, and differentiation. The encoded protein is necessary for p53-mediated caspase activation and apoptosis. Mutations in this gene are a cause of Charcot-Marie-Tooth disease type 4D, and expression of this gene may be a prognostic indicator for several types of cancer. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, May 2012]
UniProt Comments for NDRG1
NDRG1: a hypoxia-inducible anti-apoptotic protein. Promotes proliferation and correlates with invasion, metastasis and poor prognosis in many cancers. Is involved in growth arrest and cell differentiation during development. A ubiquitous Rab4a effector protein that modulates angiogenesis and is involved in vesicular recycling of E-cadherin. Colocalizes with transferrin during the recycling in cells. NDRG1 knockdown delays the recycling rate of transferrin, while its overexpression increases the rate of transferrin recycling. Interacts with SIRT1/p53 signaling to attenuate hypoxic injury in human trophoblasts. Its expression is induced by an elevation of free intracellular calcium ion caused by nickel ion exposure. Highly expressed in placental membranes, prostate, kidney, small intestine, ovary, peripheral nerves and Schwann cells. Defects in NDRG1 are the cause of Charcot-Marie-Tooth disease type 4D (CMT4D).

Protein type: Vesicle; Cell development/differentiation

Chromosomal Location of Human Ortholog: 8q24.3

Cellular Component: cell-cell adherens junction; centrosome; cytoplasm; cytosol; microtubule; microtubule cytoskeleton; myelin sheath; nucleus; perinuclear region of cytoplasm; plasma membrane; recycling endosome membrane

Molecular Function: cadherin binding; gamma-tubulin binding; microtubule binding; protein binding; Rab GTPase binding

Biological Process: DNA damage response, signal transduction by p53 class mediator; mast cell activation; myelin maintenance in the peripheral nervous system; negative regulation of cell proliferation; regulation of apoptosis; response to metal ion

Disease: Charcot-marie-tooth Disease, Type 4d
Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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