NP_072091.1
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NCBI GenBank Nucleotide #
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UniProt Related Accession #
Molecular Weight
100,716 Da
NCBI Official Full Name
bifunctional heparan sulfate N-deacetylase/N-sulfotransferase 4
NCBI Official Synonym Full Names
N-deacetylase/N-sulfotransferase (heparan glucosaminyl) 4
NCBI Protein Information
bifunctional heparan sulfate N-deacetylase/N-sulfotransferase 4; N-HSST 4; N-heparan sulfate sulfotransferase 4; glucosaminyl N-deacetylase/N-sulfotransferase 4
UniProt Protein Name
Bifunctional heparan sulfate N-deacetylase/N-sulfotransferase 4
UniProt Synonym Protein Names
Glucosaminyl N-deacetylase/N-sulfotransferase 4; NDST-4; N-heparan sulfate sulfotransferase 4; N-HSST 4
UniProt Synonym Gene Names
UniProt Entry Name
NDST4_HUMAN
UniProt Comments for NDST4
NDST4: Essential bifunctional enzyme that catalyzes both the N- deacetylation and the N-sulfation of glucosamine (GlcNAc) of the glycosaminoglycan in heparan sulfate. Modifies the GlcNAc-GlcA disaccharide repeating sugar backbone to make N-sulfated heparosan, a prerequisite substrate for later modifications in heparin biosynthesis. Has low deacetylase activity but high sulfotransferase activity. Belongs to the sulfotransferase 1 family. NDST subfamily.
Protein type: Transferase; EC 2.8.2.8; Glycan Metabolism - heparan sulfate biosynthesis; Hydrolase; Membrane protein, integral
Chromosomal Location of Human Ortholog: 4q26
Cellular Component: Golgi membrane; integral to membrane
Molecular Function: deacetylase activity; [heparan sulfate]-glucosamine N-sulfotransferase activity
Biological Process: heparin biosynthetic process; heparan sulfate proteoglycan biosynthetic process
Research Articles on NDST4
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Products associated with NDST4 elisa kit
Pathways associated with NDST4 elisa kit
Diseases associated with NDST4 elisa kit
Organs/Tissues associated with NDST4 elisa kit
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