BC018183
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UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
11,402 Da
NCBI Official Full Name
Homo sapiens NADH dehydrogenase (ubiquinone) 1 beta subcomplex, 3, 12kDa, mRNA
NCBI Official Synonym Full Names
NADH:ubiquinone oxidoreductase subunit B3
NCBI Official Synonym Symbols
NCBI Protein Information
NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 3
UniProt Protein Name
NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 3
UniProt Synonym Protein Names
Complex I-B12; CI-B12; NADH-ubiquinone oxidoreductase B12 subunit
UniProt Synonym Gene Names
UniProt Entry Name
NDUB3_HUMAN
NCBI Summary for NDUFB3
This gene encodes an accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) which is the first enzyme in the electron transport chain of mitochondria. This protein localizes to the inner membrane of the mitochondrion as a single-pass membrane protein. Mutations in this gene contribute to mitochondrial complex 1 deficiency. Alternative splicing results in multiple transcript variants encoding the same protein. Humans have multiple pseudogenes of this gene. [provided by RefSeq, Mar 2012]
UniProt Comments for NDUFB3
NDUFB3: Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone. Belongs to the complex I NDUFB3 subunit family.
Protein type: Energy Metabolism - oxidative phosphorylation; EC 1.6.5.3; Membrane protein, integral; EC 1.6.99.3; Oxidoreductase; Mitochondrial
Chromosomal Location of Human Ortholog: 2q31.3
Cellular Component: mitochondrial inner membrane; mitochondrial respiratory chain complex I
Biological Process: mitochondrial electron transport, NADH to ubiquinone; mitochondrial respiratory chain complex I assembly
Disease: Mitochondrial Complex I Deficiency
Research Articles on NDUFB3
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Pathways associated with NDUFB3 cdna clone
Diseases associated with NDUFB3 cdna clone
Organs/Tissues associated with NDUFB3 cdna clone
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