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NDUFV2 recombinant protein :: NADH dehydrogenase [ubiquinone] flavoprotein 2 Recombinant Protein

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Catalog # MBS717229
Unit / Price
  0.01 mg  /  $160 +1 FREE 8GB USB
  0.05 mg  /  $200 +1 FREE 8GB USB
  0.1 mg  /  $295 +1 FREE 8GB USB
  0.2 mg  /  $480 +1 FREE 8GB USB
  0.5 mg  /  $790 +1 FREE 8GB USB
  1 mg  /  $1,215 +1 FREE 8GB USB
SDS-PAGE
Product Name

NADH dehydrogenase [ubiquinone] flavoprotein 2 (NDUFV2), Recombinant Protein

Full Product Name

Recombinant Human NADH dehydrogenase [ubiquinone] flavoprotein 2, mitochondrial

Product Synonym Names
NADH-ubiquinone oxidoreductase 24 kDa subunit
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
Sequence Positions
35-249aa; Partial
Sequence
GGALFVHRDT PENNPDTPFD FTPENYKRIE AIVKNYPEGH KAAAVLPVLD LAQRQNGWLP ISAMNKVAEV LQVPPMRVYE VATFYTMYNR KPVGKYHIQV CTTTPCMLRN SDSILEAIQK KLGIKVGETT PDKLFTLIEV ECLGACVNAP MVQINDNYYE DLTAKDIEEI IDELKAGKIP KPGPRSGRFS CEPAGGLTSL TEPPKGPGFG VQAGL
OMIM
600532
3D Structure
ModBase 3D Structure for P19404
Host
E Coli
Purity/Purification
Greater than 90% as determined by SDS-PAGE. (lot specific)
Form/Format
Liquid containing glycerol
Tag Information
This protein contains an N-terminal tag and may also contain a C-terminal tag. Tag types are determined by various factors including tag-protein stability, please inquire for tag information.
Sterility
Sterile filter available upon request.
Endotoxin
Low endotoxin available upon request.
Preparation and Storage
Store at -20 degree C, for extended storage, conserve at -20 degree C or -80 degree C.
ISO Certification
Manufactured in an ISO 9001:2008 Certified Laboratory.
Other Notes
Small volumes of NDUFV2 recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Related Product Information for
NDUFV2 recombinant protein
Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) that is believed to belong to the minimal assembly required for catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.
Product Categories/Family for NDUFV2 recombinant protein

NDUFV2 recombinant protein SDS-PAGE image
(Note: Representative image, actual molecular weight may vary depending on Tag type and expression host)
NCBI/Uniprot data below describe general gene information for NDUFV2. It may not necessarily be applicable to this product.
NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
UniProt Primary Accession #
UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
51kD
NCBI Official Full Name
NADH dehydrogenase
NCBI Official Synonym Full Names
NADH:ubiquinone oxidoreductase core subunit V2
NCBI Official Symbol
NDUFV2  [Similar Products]
NCBI Official Synonym Symbols
CI-24k
  [Similar Products]
NCBI Protein Information
NADH dehydrogenase [ubiquinone] flavoprotein 2, mitochondrial
UniProt Protein Name
NADH dehydrogenase [ubiquinone] flavoprotein 2, mitochondrial
UniProt Synonym Protein Names
NADH-ubiquinone oxidoreductase 24 kDa subunit
UniProt Gene Name
NDUFV2  [Similar Products]
UniProt Entry Name
NDUV2_HUMAN
NCBI Summary for NDUFV2
The NADH-ubiquinone oxidoreductase complex (complex I) of the mitochondrial respiratory chain catalyzes the transfer of electrons from NADH to ubiquinone, and consists of at least 43 subunits. The complex is located in the inner mitochondrial membrane. This gene encodes the 24 kDa subunit of complex I, and is involved in electron transfer. Mutations in this gene are implicated in Parkinson's disease, bipolar disorder, schizophrenia, and have been found in one case of early onset hypertrophic cardiomyopathy and encephalopathy. A non-transcribed pseudogene of this locus is found on chromosome 19. [provided by RefSeq, Oct 2009]
UniProt Comments for NDUFV2
NDUFV2: Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) that is believed to belong to the minimal assembly required for catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone. Belongs to the complex I 24 kDa subunit family.

Protein type: Energy Metabolism - oxidative phosphorylation; Mitochondrial; Oxidoreductase; EC 1.6.99.3; EC 1.6.5.3

Chromosomal Location of Human Ortholog: 18p11.22

Cellular Component: mitochondrial inner membrane; mitochondrial respiratory chain complex I; mitochondrion; myelin sheath

Molecular Function: 2 iron, 2 sulfur cluster binding; electron carrier activity; metal ion binding; NADH dehydrogenase (ubiquinone) activity

Biological Process: cardiac muscle development; cellular metabolic process; mitochondrial electron transport, NADH to ubiquinone; mitochondrial respiratory chain complex I assembly; nervous system development

Disease: Mitochondrial Complex I Deficiency
Product References and Citations for NDUFV2 recombinant protein
Mitochondrial NADH-ubiquinone reductase complementary DNA sequences of import precursors of the bovine and human 24-kDa subunit.Pilkington S.J., Walker J.E.Biochemistry 28:3257-3264(1989) The subunit composition of the human NADH dehydrogenase obtained by rapid one-step immunopurification.Murray J., Zhang B., Taylor S.W., Oglesbee D., Fahy E., Marusich M.F., Ghosh S.S., Capaldi R.A.J. Biol. Chem. 278:13619-13622(2003) Initial characterization of the human central proteome.Burkard T.R., Planyavsky M., Kaupe I., Breitwieser F.P., Buerckstuemmer T., Bennett K.L., Superti-Furga G., Colinge J.BMC Syst. Biol. 5:17-17(2011) Mitochondrial c-Src regulates cell survival through phosphorylation of respiratory chain components.Ogura M., Yamaki J., Homma M.K., Homma Y.Biochem. J. 447:281-289(2012) An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.Bian Y., Song C., Cheng K., Dong M., Wang F., Huang J., Sun D., Wang L., Ye M., Zou H.J. Proteomics 96:253-262(2014)

Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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