EAW99260.1
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UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
43,684 Da
NCBI Official Full Name
nei endonuclease VIII-like 1 (E. coli), isoform CRA_a
NCBI Official Synonym Full Names
nei like DNA glycosylase 1
NCBI Protein Information
endonuclease 8-like 1
UniProt Protein Name
Endonuclease 8-like 1
UniProt Synonym Protein Names
DNA glycosylase/AP lyase Neil1; DNA-(apurinic or apyrimidinic site) lyase Neil1; Endonuclease VIII-like 1; FPG1; Nei homolog 1; NEH1; Nei-like protein 1
UniProt Synonym Gene Names
NCBI Summary for NEIL1
This gene is a member of the Nei endonuclease VIII-like gene family which encodes DNA glycosylases. The encoded enzyme participates in the DNA repair pathway by initiating base excision repair by removing damaged bases, primarily oxidized pyrimidines. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Feb 2012]
UniProt Comments for NEIL1
Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases. Has a preference for oxidized pyrimidines, such as thymine glycol, formamidopyrimidine (Fapy) and 5-hydroxyuracil. Has marginal activity towards 8-oxoguanine. Has AP (apurinic/apyrimidinic) lyase activity and introduces nicks in the DNA strand. Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'-phosphates. Has DNA glycosylase/lyase activity towards mismatched uracil and thymine, in particular in U:C and T:C mismatches. Specifically binds 5-hydroxymethylcytosine (5hmC), suggesting that it acts as a specific reader of 5hmC.
Research Articles on NEIL1
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Products associated with NEIL1 antibody pair kit
Pathways associated with NEIL1 antibody pair kit
Diseases associated with NEIL1 antibody pair kit
Organs/Tissues associated with NEIL1 antibody pair kit
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