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NF1 recombinant protein :: Neurofibromin (NF1) Recombinant Protein

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Catalog # MBS953948
Unit / Price
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  0.5 mg (E-Coli)  /  $1,345 +1 FREE 8GB USB
  0.05 mg (Baculovirus)  /  $1,345 +1 FREE 8GB USB
  0.5 mg (Yeast)  /  $1,565 +1 FREE 8GB USB
  0.05 mg (Mammalian-Cell)  /  $1,565 +1 FREE 8GB USB
  1 mg (E-Coli)  /  $2,190 +2 FREE 8GB USB
  0.1 mg (Baculovirus)  /  $2,190 +2 FREE 8GB USB
  1 mg (Yeast)  /  $2,650 +3 FREE 8GB USB
  0.1 mg (Mammalian-Cell)  /  $2,650 +3 FREE 8GB USB
NF1 recombinant protein
Product Name

Neurofibromin (NF1), Recombinant Protein

Popular Item
Full Product Name

Recombinant Human Neurofibromin (NF1) , partial

Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
Sequence Positions
2-551; Isoform 3 (identifier: P21359-3), full length
Sequence
AAHRPVEWVQ AVVSRFDEQL PIKTGQQNTH TKVSTEHNKE CLINISKYKF SLVISGLTTI LKNVNNMRIF GEAAEKNLYL SQLIILDTLE KCLAGQPKDT MRLDETMLVK QLLPEICHFL HTCREGNQHA AELRNSASGV LFSLSCNNFN AVFSRISTRL QELTVCSEDN VDVHDIELLQ YINVDCAKLK RLLKETAFKF KALKKVAQLA VINSLEKAFW NWVENYPDEF TKLYQIPQTD MAECAEKLFD LVDGFAESTK RKAAVWPLQI ILLILCPEII QDISKDVVDE NNMNKKLFLD SLRKALAGHG GSRQLTESAA IACVKLCKAS TYINWEDNSV IFLLVQSMVV DLKNLLFNPS KPFSRGSQPA DVDLMIDCLV SCFRISPHNN QHFKICLAQN SPSTFHYVLV NSLHRIITNS ALDWWPKIDA VYCHSVELRN MFGETLHKAV QGCGAHPAIR MAPSLTFKEK VTSLKFKEKP TDLETRSYKY LLLSMVKLIH ADPKLLLCNP RKQGPETQGS TAELITGLVQ LVPQSHMPEI AQEAMEVRGK
OMIM
114500
3D Structure
ModBase 3D Structure for P21359
Host
E Coli or Yeast or Baculovirus or Mammalian Cell
Purity/Purification
>85% (SDS-PAGE) (lot specific)
Form/Format
Liquid containing glycerol
Tag Information
This protein contains an N-terminal tag and may also contain a C-terminal tag. Tag types are determined by various factors including tag-protein stability, please inquire for tag information.
Sterility
Sterile filter available upon request.
Endotoxin
Low endotoxin available upon request.
Species
Human
Storage Buffer
Tris-based buffer, 50% glycerol
Tag Information
Tag type will be determined during the manufacturing process
Preparation and Storage
Store at -20 degrees C. For long-term storage, store at -20 degrees C or -80 degrees C. Store working aliquots at 4 degrees C for up to one week. Repeated freezing and thawing is not recommended.
ISO Certification
Manufactured in an ISO 9001:2008 Certified Laboratory.
Other Notes
Small volumes of NF1 recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Related Product Information for
NF1 recombinant protein
This gene product appears to function as a negative regulator of the ras signal transduction pathway. Mutations in this gene have been linked to neurofibromatosis type 1, juvenile myelomonocytic leukemia and Watson syndrome. The mRNA for this gene is subject to RNA editing (CGA>UGA->Arg1306Term) resulting in premature translation termination. Alternatively spliced transcript variants encoding different isoforms have also been described for this gene.
NCBI/Uniprot data below describe general gene information for NF1. It may not necessarily be applicable to this product.
NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
UniProt Primary Accession #
UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
318,992 Da
NCBI Official Full Name
neurofibromin isoform 2
NCBI Official Synonym Full Names
neurofibromin 1
NCBI Official Symbol
NCBI Official Synonym Symbols
WSS; NFNS; VRNF
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NCBI Protein Information
neurofibromin
UniProt Protein Name
Neurofibromin
UniProt Synonym Protein Names
Neurofibromatosis-related protein NF-1
Protein Family
UniProt Gene Name
NCBI Summary for NF1
This gene product appears to function as a negative regulator of the ras signal transduction pathway. Mutations in this gene have been linked to neurofibromatosis type 1, juvenile myelomonocytic leukemia and Watson syndrome. The mRNA for this gene is subject to RNA editing (CGA>UGA->Arg1306Term) resulting in premature translation termination. Alternatively spliced transcript variants encoding different isoforms have also been described for this gene. [provided by RefSeq, Jul 2008]
UniProt Comments for NF1
Stimulates the GTPase activity of Ras. NF1 shows greater affinity for Ras GAP, but lower specific activity. May be a regulator of Ras activity.
Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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