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NMNAT1 cdna clone

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Catalog # MBS1273835
Unit / Price
  0.01 mg Plasmid + 0.2 mL Glycerol-Stock  /  $165 +1 FREE 8GB USB
NMNAT1 cdna clone
Product Name

NMNAT1, cDNA Clone

Also Known As

NMNAT1 cDNA Clone

Product Gene Name
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
Sequence Length
840
Sequence
atggaaaatt ccgagaagac tgaagtggtt ctccttgctt gtggttcatt caatcccatc accaacatgc acctcaggtt gtttgagctg gccaaggact acatgaatgg aacaggaagg tacacagttg tcaaaggcat catctctcct gttggtgatg cctacaagaa gaaaggactc attcctgcct atcaccgggt catcatggca gaacttgcta ccaagaattc taaatgggtg gaagttgata catgggaaag tcttcagaag gagtggaaag agactctgaa ggtgctaaga caccatcaag agaaattgga ggctagtgac tgtgatcacc agcagaactc acctactcta gaaaggcctg gaaggaagag gaagtggact gaaacacaag attctagtca aaagaaatcc ctagagccaa aaacaaaagc tgtgccaaag gtcaagctgc tgtgtggggc agatttattg gagtcctttg ctgttcccaa tttgtggaag agtgaagaca tcacccaaat cgtggccaac tatgggctca tatgtgttac tcgggctgga aatgatgctc agaagtttat ctatgaatcg gatgtgctgt ggaaacaccg gagcaacatt cacgtggtga atgaatggat cgctaatgac atctcatcca caaaaatccg gagagccctc agaaggggcc agagcattcg ctacttggta ccagatcttg tccaagaata cattgaaaag cataatttgt acagctctga gagtgaagac aggaatgctg gggtcatcct ggcccctttg cagagaaaca ctgcagaagc taagacatag
OMIM
608553
Vector
pENTR223.1 or pUC
Clone Sequence Report
Provided with product shipment
ISO Certification
Manufactured in an ISO 9001:2008 Certified Laboratory.
Other Notes
Small volumes of NMNAT1 cdna clone vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
NCBI/Uniprot data below describe general gene information for NMNAT1. It may not necessarily be applicable to this product.
NCBI GI #
NCBI GeneID
NCBI Accession #
UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
31,932 Da
NCBI Official Full Name
Homo sapiens nicotinamide nucleotide adenylyltransferase 1, mRNA
NCBI Official Synonym Full Names
nicotinamide nucleotide adenylyltransferase 1
NCBI Official Symbol
NMNAT1  [Similar Products]
NCBI Official Synonym Symbols
LCA9; NMNAT; PNAT1
  [Similar Products]
NCBI Protein Information
nicotinamide/nicotinic acid mononucleotide adenylyltransferase 1
UniProt Protein Name
Nicotinamide/nicotinic acid mononucleotide adenylyltransferase 1
UniProt Synonym Protein Names
Nicotinamide-nucleotide adenylyltransferase 1; NMN adenylyltransferase 1; Nicotinate-nucleotide adenylyltransferase 1; NaMN adenylyltransferase 1
UniProt Gene Name
NMNAT1  [Similar Products]
UniProt Synonym Gene Names
NMNAT; NMN/NaMN adenylyltransferase 1; NMN adenylyltransferase 1; NaMN adenylyltransferase 1  [Similar Products]
UniProt Entry Name
NMNA1_HUMAN
NCBI Summary for NMNAT1
This gene encodes an enzyme which catalyzes a key step in the biosynthesis of nicotinamide adenine dinucleotide (NAD). The encoded enzyme is one of several nicotinamide nucleotide adenylyltransferases, and is specifically localized to the cell nucleus. Activity of this protein leads to the activation of a nuclear deacetylase that functions in the protection of damaged neurons. Mutations in this gene have been associated with Leber congenital amaurosis 9. Alternative splicing results in multiple transcript variants. Pseudogenes of this gene are located on chromosomes 1, 3, 4, 14, and 15. [provided by RefSeq, Jul 2014]
UniProt Comments for NMNAT1
NMNAT1: Catalyzes the formation of NAD(+) from nicotinamide mononucleotide (NMN) and ATP. Can also use the deamidated form; nicotinic acid mononucleotide (NaMN) as substrate with the same efficiency. Can use triazofurin monophosphate (TrMP) as substrate. Also catalyzes the reverse reaction, i.e. the pyrophosphorolytic cleavage of NAD(+). For the pyrophosphorolytic activity, prefers NAD(+) and NAAD as substrates and degrades NADH, nicotinic acid adenine dinucleotide phosphate (NHD) and nicotinamide guanine dinucleotide (NGD) less effectively. Fails to cleave phosphorylated dinucleotides NADP(+), NADPH and NAADP(+). Protects against axonal degeneration following mechanical or toxic insults. Belongs to the eukaryotic NMN adenylyltransferase family.

Protein type: Cofactor and Vitamin Metabolism - nicotinate and nicotinamide; EC 2.7.7.1; EC 2.7.7.18; Transferase

Chromosomal Location of Human Ortholog: 1p36.22

Cellular Component: nucleoplasm; nucleus

Molecular Function: identical protein binding; nicotinamide-nucleotide adenylyltransferase activity; nicotinate-nucleotide adenylyltransferase activity; protein binding

Biological Process: NAD biosynthetic process; NAD metabolic process

Disease: Leber Congenital Amaurosis 9
Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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