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NNMT recombinant protein :: Nicotinamide N-Methyltransferase Recombinant Protein

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Catalog # MBS143908
Unit / Price
  0.005 mg  /  $140 +1 FREE 8GB USB
  0.025 mg  /  $205 +1 FREE 8GB USB
  1 mg  /  $2,665 +3 FREE 8GB USB
NNMT recombinant protein
Product Name

Nicotinamide N-Methyltransferase (NNMT), Recombinant Protein

Also Known As

Recombinant Human Nicotinamide N-Methyltransferase

Product Synonym Names
NNMT Human; Nicotinamide N-Methyltransferase Human Recombinant; Nicotineamide N-methyltransferase; NNMT
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
Sequence Length
264
Sequence
MGSSHHH HHH SSGLVPRGSH MESGFTSKDT YLSHFNPRDY LEKYYKFGSR HSAESQILKH LLKNLFKIFC LDGVKGDLLI DIGSGPTIYQ LLSACESFKE IVVTDYSDQN LQELEKWLKK EPEAFDWSPV VTYVCDLEGN RVKGPEKEEK LRQAVKQVLK CDVTQSQPLG AVPLPPADCV LSTLCLDAAC PDLPTYCRAL RNLGSLLKPG GFLVIMDALK SSYYMIGEQK FSSLPLGREA VEAAVKEAGY TIEWFEVISQ SYSSTMANNE GLFSLVARKL SRPL
OMIM
600008
3D Structure
ModBase 3D Structure for P40261
Host
E Coli
Purity/Purification
Greater than 95.0% as determined by SDS-PAGE.
Form/Format
The NNMT solution contains 20mM Tris pH 8.0 & 20% glycerol.
Sterile Filtered colorless solution.
Preparation and Storage
NNMT although stable 4 degree C for 4 weeks, should be stored desiccated below -18 degree C. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Please prevent freeze-thaw cycles.
Other Notes
Small volumes of NNMT recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Related Product Information for
NNMT recombinant protein
Description: NNMT Human Recombinant fused with 20 amino acid His-Tag tag at N-terminus produced in E Coli is a single, non-glycosylated, polypeptide chain containing a total of 284 amino acids (1-264 a.a.) and having a molecular mass of 31.7 kDa.The NNMT is purified by proprietary chromatographic techniques.

Introduction: NNMT is part of the family of transferases, especially those transferring one-carbon group methyltransferases. NNMT is mostly expressed in the liver, and a lower expression is seen in the kidney, lung, skeletal muscle, placenta and heart. NNMT catalyzes the N-methylation of nicotinamide and other pyridines to form pyridinium ions. This activity is significant for biotransformation of many drugs and xenobiotic compounds. NNMT is accountable for the enzymatic activity which uses S-adenosyl methionine as the methyl donor. NNMT expression is related with tumor stage and DFS time in hepatocellular carcinoma cases. NNMT is a good candidate as a tumor marker of various kinds of cancers. NNMT serum levels have significance in the premature detection and in the management of patients with colorectal cancer.
NCBI/Uniprot data below describe general gene information for NNMT. It may not necessarily be applicable to this product.
NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
UniProt Primary Accession #
UniProt Related Accession #
Molecular Weight
29,574 Da
NCBI Official Full Name
nicotinamide N-methyltransferase
NCBI Official Synonym Full Names
nicotinamide N-methyltransferase
NCBI Official Symbol
NCBI Protein Information
nicotinamide N-methyltransferase
UniProt Protein Name
Nicotinamide N-methyltransferase
UniProt Gene Name
UniProt Entry Name
NNMT_HUMAN
NCBI Summary for NNMT
N-methylation is one method by which drug and other xenobiotic compounds are metabolized by the liver. This gene encodes the protein responsible for this enzymatic activity which uses S-adenosyl methionine as the methyl donor. [provided by RefSeq, Jul 2008]
UniProt Comments for NNMT
NNMT: Catalyzes the N-methylation of nicotinamide and other pyridines to form pyridinium ions. This activity is important for biotransformation of many drugs and xenobiotic compounds. Belongs to the NNMT/PNMT/TEMT family.

Protein type: Cofactor and Vitamin Metabolism - nicotinate and nicotinamide; EC 2.1.1.1; Methyltransferase

Chromosomal Location of Human Ortholog: 11q23.1

Cellular Component: cytosol

Molecular Function: nicotinamide N-methyltransferase activity

Biological Process: response to drug; methylation; organ regeneration; xenobiotic metabolic process; response to organic nitrogen
Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
Pathways associated with NNMT recombinant protein
 Products by Pathway  Pathway Diagram
 Biological Oxidations Pathway antibodies  Biological Oxidations Pathway Diagram
 Defective AHCY Causes Hypermethioninemia With S-adenosylhomocysteine Hydrolase Deficiency (HMAHCHD) Pathway antibodies  Defective AHCY Causes Hypermethioninemia With S-adenosylhomocysteine Hydrolase Deficiency (HMAHCHD) Pathway Diagram
 Defective GCLC Causes Hemolytic Anemia Due To Gamma-glutamylcysteine Synthetase Deficiency (HAGGSD) Pathway antibodies  Defective GCLC Causes Hemolytic Anemia Due To Gamma-glutamylcysteine Synthetase Deficiency (HAGGSD) Pathway Diagram
 Defective GGT1 Causes Glutathionuria (GLUTH) Pathway antibodies  Defective GGT1 Causes Glutathionuria (GLUTH) Pathway Diagram
 Defective GSS Causes Glutathione Synthetase Deficiency (GSS Deficiency) Pathway antibodies  Defective GSS Causes Glutathione Synthetase Deficiency (GSS Deficiency) Pathway Diagram
 Defective MAT1A Causes Methionine Adenosyltransferase Deficiency (MATD) Pathway antibodies  Defective MAT1A Causes Methionine Adenosyltransferase Deficiency (MATD) Pathway Diagram
 Defective OPLAH Causes 5-oxoprolinase Deficiency (OPLAHD) Pathway antibodies  Defective OPLAH Causes 5-oxoprolinase Deficiency (OPLAHD) Pathway Diagram
 Defective SLC35D1 Causes Schneckenbecken Dysplasia (SCHBCKD) Pathway antibodies  Defective SLC35D1 Causes Schneckenbecken Dysplasia (SCHBCKD) Pathway Diagram
 Defective TPMT Causes Thiopurine S-methyltransferase Deficiency (TPMT Deficiency) Pathway antibodies  Defective TPMT Causes Thiopurine S-methyltransferase Deficiency (TPMT Deficiency) Pathway Diagram
 Defective UGT1A1 Causes Hyperbilirubinemia Pathway antibodies  Defective UGT1A1 Causes Hyperbilirubinemia Pathway Diagram
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