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NONO cdna clone

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Catalog # MBS1277337
Unit / Price
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  0.01 mg Plasmid + 0.2 mL Glycerol-Stock  /  $165 +1 FREE 8GB USB
NONO cdna clone
Product Name

NONO, cDNA Clone

Full Product Name

NONO cDNA Clone

Product Gene Name
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
Sequence
atgccactcc gtggaaagca gctgcgtgtg cgctttgcct gccatagtgc atcccttaca gttcgaaacc ttcctcagta tgtgtccaac gaactgctgg aagaagcctt ttctgtgttt ggccaggtag agagggctgt agtcattgtg gatgatcgag gaaggccctc aggaaaaggc attgttgagt tctcagggaa gccagctgct cggaaagctc tggacagatg cagtgaaggc tccttcctgc taaccacatt tcctcgtcct gtgactgtgg agcccatgga ccagttagat gatgaagagg gacttccaga gaagctggtt ataaaaaacc agcaatttca caaggaacga gagcagccac ccagatttgc acagcctggc tcctttgagt atgaatatgc catgcgctgg aaggcactca ttgagatgga gaagcagcag caggaccaag tggaccgcaa catcaaggag gctcgtgaga agctggagat ggagatggaa gctgcacgcc atgagcacca ggtcatgcta atgagacagg atttgatgag gcgccaagaa gaacttcgga ggatggaaga gctgcacaac caagaggtgc aaaaacgaaa gcaactggag ctcaggcagg aggaagagcg caggcgccgt gaagaagaga tgcggcggca gcaagaagaa atgatgcggc gacagcagga aggattcaag ggaaccttcc ctgatgcgag agagcaggag attcggatgg gtcagatggc tatgggaggt gctatgggca taaacaacag aggtgccatg ccccctgctc ctgtgccagc tggtacccca gctcctccag gacctgccac tatgatgccg gatggaactt tgggattgac cccaccaaca actgaacgct ttggtcaggc tgctacaatg gaaggaattg gggcaattgg tggaactcct cctgcattca accgtgcagc tcctggagct gaatttgccc caaacaaacg tcgccgatac taa
OMIM
300084
Vector
pENTR223.1 or pUC
Clone Sequence Report
Provided with product shipment
ISO Certification
Manufactured in an ISO 9001:2008 Certified Laboratory.
Other Notes
Small volumes of NONO cdna clone vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
NCBI/Uniprot data below describe general gene information for NONO. It may not necessarily be applicable to this product.
NCBI GI #
NCBI GeneID
NCBI Accession #
UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
43,866 Da
NCBI Official Full Name
Homo sapiens non-POU domain containing, octamer-binding, mRNA
NCBI Official Synonym Full Names
non-POU domain containing, octamer-binding
NCBI Official Symbol
NCBI Official Synonym Symbols
P54; NMT55; NRB54; MRXS34; P54NRB; PPP1R114
  [Similar Products]
NCBI Protein Information
non-POU domain-containing octamer-binding protein
UniProt Protein Name
Non-POU domain-containing octamer-binding protein
UniProt Synonym Protein Names
54 kDa nuclear RNA- and DNA-binding protein; 55 kDa nuclear protein; DNA-binding p52/p100 complex, 52 kDa subunit; NMT55; p54(nrb); p54nrb
UniProt Gene Name
UniProt Synonym Gene Names
NRB54; NonO protein; p54nrb  [Similar Products]
UniProt Entry Name
NONO_HUMAN
NCBI Summary for NONO
This gene encodes an RNA-binding protein which plays various roles in the nucleus, including transcriptional regulation and RNA splicing. A rearrangement between this gene and the transcription factor E3 gene has been observed in papillary renal cell carcinoma. Alternatively spliced transcript variants have been described. Pseudogenes exist on Chromosomes 2 and 16. [provided by RefSeq, Feb 2009]
UniProt Comments for NONO
NONO: DNA- and RNA binding protein, involved in several nuclear processes. Binds the conventional octamer sequence in double stranded DNA. Also binds single-stranded DNA and RNA at a site independent of the duplex site. Involved in pre-mRNA splicing, probably as a heterodimer with SFPQ. Interacts with U5 snRNA, probably by binding to a purine-rich sequence located on the 3' side of U5 snRNA stem 1b. The SFPQ-NONO heteromer associated with MATR3 may play a role in nuclear retention of defective RNAs. The SFPQ-NONO heteromer may be involved in DNA unwinding by modulating the function of topoisomerase I/TOP1. The SFPQ-NONO heteromer may be involved in DNA nonhomologous end joining (NHEJ) required for double-strand break repair and V(D)J recombination and may stabilize paired DNA ends. In vitro, the complex strongly stimulates DNA end joining, binds directly to the DNA substrates and cooperates with the Ku70/G22P1-Ku80/XRCC5 (Ku) dimer to establish a functional preligation complex. NONO is involved in transcriptional regulation. The SFPQ-NONO-NR5A1 complex binds to the CYP17 promoter and regulates basal and cAMP-dependent transcriptional avtivity. NONO binds to an enhancer element in long terminal repeats of endogenous intracisternal A particles (IAPs) and activates transcription. Together with PSPC1, required for the formation of nuclear paraspeckles. A chromosomal aberration involving NONO may be a cause of papillary renal cell carcinoma (PRCC). Translocation t(X;X)(p11.2;q13.1) with TFE3.

Protein type: RNA splicing; RNA-binding; Nucleolus; Nuclear receptor co-regulator

Chromosomal Location of Human Ortholog: Xq13.1

Cellular Component: membrane; nuclear matrix; nucleoplasm; nucleus; paraspeckles

Molecular Function: chromatin binding; identical protein binding; protein binding

Biological Process: circadian rhythm; mRNA processing; negative regulation of transcription, DNA-dependent; nuclear mRNA splicing, via spliceosome; regulation of circadian rhythm; regulation of transcription, DNA-dependent; RNA splicing

Disease: Mental Retardation, X-linked, Syndromic 34
Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
Pathways associated with NONO cdna clone
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