NP_000616.3
[Other Products]
NCBI GenBank Nucleotide #
|
[Other Products]
UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
126,749 Da
NCBI Official Full Name
nitric oxide synthase, inducible
NCBI Official Synonym Full Names
nitric oxide synthase 2
NCBI Protein Information
nitric oxide synthase, inducible
UniProt Protein Name
Nitric oxide synthase, inducible
UniProt Synonym Protein Names
Hepatocyte NOS; HEP-NOS; Inducible NO synthase; Inducible NOS; iNOS; NOS type II; Peptidyl-cysteine S-nitrosylase NOS2
UniProt Synonym Gene Names
UniProt Entry Name
NOS2_HUMAN
NCBI Summary for NOS2/iNOS
Nitric oxide is a reactive free radical which acts as a biologic mediator in several processes, including neurotransmission and antimicrobial and antitumoral activities. This gene encodes a nitric oxide synthase which is expressed in liver and is inducible by a combination of lipopolysaccharide and certain cytokines. Three related pseudogenes are located within the Smith-Magenis syndrome region on chromosome 17. [provided by RefSeq, Jul 2008]
UniProt Comments for NOS2/iNOS
iNOS: Produces nitric oxide (NO) which is a messenger molecule with diverse functions throughout the body. In macrophages, NO mediates tumoricidal and bactericidal actions. Also has nitrosylase activity and mediates cysteine S-nitrosylation of cytoplasmic target proteins such COX2. Homodimer. Binds SLC9A3R1. By endotoxins and cytokines. Induced by IFNG/IFN-gamma acting synergistically with bacterial lipopolysaccharides (LPS), TNF or IL1B/interleukin-1 beta. Expressed in the liver, retina, bone cells and airway epithelial cells of the lung. Not expressed in the platelets. Regulated by calcium/calmodulin. Aspirin inhibits expression and function of this enzyme and effects may be exerted at the level of translational/post-translational modification and directly on the catalytic activity. Belongs to the NOS family. 2 isoforms of the human protein are produced by alternative splicing.
Protein type: Oxidoreductase; EC 1.14.13.39; Amino Acid Metabolism - arginine and proline
Chromosomal Location of Human Ortholog: 17q11.2
Cellular Component: cortical cytoskeleton; cytoplasm; cytosol; intracellular; nucleus; perinuclear region of cytoplasm; peroxisome
Molecular Function: calmodulin binding; FAD binding; FMN binding; heme binding; iron ion binding; NADP binding; nitric-oxide synthase activity; protein binding; protein homodimerization activity; receptor binding
Biological Process: arginine catabolic process; blood coagulation; cell redox homeostasis; circadian rhythm; defense response to bacterium; defense response to Gram-negative bacterium; inflammatory response; innate immune response in mucosa; negative regulation of blood pressure; negative regulation of protein catabolic process; nitric oxide biosynthetic process; nitric oxide mediated signal transduction; peptidyl-cysteine S-nitrosylation; positive regulation of guanylate cyclase activity; positive regulation of killing of cells of another organism; positive regulation of leukocyte mediated cytotoxicity; positive regulation of vasodilation; prostaglandin secretion; regulation of cell proliferation; regulation of cellular respiration; regulation of insulin secretion; response to bacterium; response to hypoxia; superoxide metabolic process
Disease: Hypertension, Essential; Malaria, Susceptibility To
Research Articles on NOS2/iNOS
Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice. It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
Products associated with NOS2/iNOS elisa kit
Pathways associated with NOS2/iNOS elisa kit
Diseases associated with NOS2/iNOS elisa kit
Organs/Tissues associated with NOS2/iNOS elisa kit
|