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NPM1 cdna clone

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Catalog # MBS1271714
Unit / Price
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  0.01 mg Plasmid + 0.2 mL Glycerol-Stock  /  $165 +1 FREE 8GB USB
NPM1 cdna clone
Product Name

NPM1, cDNA Clone

Full Product Name

NPM1 cDNA Clone

Product Gene Name
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
Sequence
atggaagatt cgatggacat ggacatgagc cccctgaggc cccagaacta tcttttcggt tgtgaactaa aggccgacaa agattatcac tttaaggtgg ataatgatga aaatgagcac cagttatctt taagaacggt cagtttaggg gctggtgcaa aggatgagtt gcacattgtt gaagcagagg caatgaatta cgaaggcagt ccaattaaag taacactggc aactttgaaa atgtctgtac agccaacggt ttcccttggg ggctttgaaa taacaccacc agtggtctta aggttgaagt gtggttcagg gccagtgcat attagtggac agcacttagt agctgtggag gaagatgcag agtcagaaga tgaagaggag gaggatgtga aactcttaag tatatctgga aagcggtctg cccctggagg tggtagcaag gttccacaga aaaaagtaaa acttgctgct gatgaagatg atgacgatga tgatgaagag gatgatgatg aagatgatga tgatgatgat tttgatgatg aggaagctga agaaaaagcg ccagtgaaga aaggacaaga atccttcaag aaacaggaaa aaactcctaa aacaccaaaa ggacctagtt ctgtagaaga cattaaagca aaaatgcaag caagtataga aaaaggtggt tctcttccca aagtggaagc caaattcatc aattatgtga agaattgctt ccggatgact gaccaagagg ctattcaaga tctctggcag tggaggaagt ctctttaa
OMIM
164040
Vector
pENTR223.1 or pUC
Clone Sequence Report
Provided with product shipment
ISO Certification
Manufactured in an ISO 9001:2008 Certified Laboratory.
Other Notes
Small volumes of NPM1 cdna clone vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
NCBI/Uniprot data below describe general gene information for NPM1. It may not necessarily be applicable to this product.
NCBI GI #
NCBI GeneID
NCBI Accession #
UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
28,400 Da
NCBI Official Full Name
Homo sapiens nucleophosmin (nucleolar phosphoprotein B23, numatrin), mRNA
NCBI Official Synonym Full Names
nucleophosmin
NCBI Official Symbol
NCBI Official Synonym Symbols
B23; NPM
  [Similar Products]
NCBI Protein Information
nucleophosmin
UniProt Protein Name
Nucleophosmin
UniProt Synonym Protein Names
Nucleolar phosphoprotein B23; Nucleolar protein NO38; Numatrin
Protein Family
UniProt Gene Name
UniProt Synonym Gene Names
NPM; NPM  [Similar Products]
UniProt Entry Name
NPM_HUMAN
NCBI Summary for NPM1
This gene encodes a phosphoprotein which moves between the nucleus and the cytoplasm. The gene product is thought to be involved in several processes including regulation of the ARF/p53 pathway. A number of genes are fusion partners have been characterized, in particular the anaplastic lymphoma kinase gene on chromosome 2. Mutations in this gene are associated with acute myeloid leukemia. More than a dozen pseudogenes of this gene have been identified. Alternative splicing results in multiple transcript variants.[provided by RefSeq, Nov 2009]
UniProt Comments for NPM1
NPM1: a nucleolar protein associated with nucleolar ribonucleoprotein structures and that binds single-stranded nucleic acids. Is a major component of template activating factor (TAF)-III. It plays a role in controlling centrosome duplication, and may function in the assembly and/or transport of the ribosome. Two alternatively spliced isoforms have been described.

Protein type: Nucleolus; Translation; Oncoprotein; RNA-binding

Chromosomal Location of Human Ortholog: 5q35.1

Cellular Component: centrosome; cytoplasm; cytosol; focal adhesion; membrane; nucleolus; nucleoplasm; nucleus; ribonucleoprotein complex; spindle pole centrosome

Molecular Function: histone binding; NF-kappaB binding; protein binding; protein heterodimerization activity; protein homodimerization activity; protein kinase binding; protein kinase inhibitor activity; ribosomal large subunit binding; ribosomal small subunit binding; RNA binding; Tat protein binding; transcription coactivator activity; unfolded protein binding

Biological Process: activation of NF-kappaB transcription factor; cell aging; centrosome cycle; DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest; DNA repair; DNA replication-independent nucleosome assembly at centromere; intracellular protein transport; negative regulation of apoptosis; negative regulation of cell proliferation; nucleocytoplasmic transport; nucleosome assembly; positive regulation of cell proliferation; positive regulation of transcription, DNA-dependent; positive regulation of translation; protein localization; protein oligomerization; regulation of centriole replication; regulation of endodeoxyribonuclease activity; response to stress; ribosome assembly
Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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