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NPR1 elisa kit :: Canine Atrial natriuretic peptide receptor 1 (NPR1) ELISA Kit

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Catalog # MBS7241665
Unit / Price
  48-Strip-Wells  /  $440 +1 FREE 8GB USB
  96-Strip-Wells  /  $640 +1 FREE 8GB USB
  5x96-Strip-Wells  /  $2,895 +3 FREE 8GB USB
  10x96-Strip-Wells  /  $5,415 +6 FREE 8GB USB
NPR1 elisa kit
Product Name

Atrial natriuretic peptide receptor 1 (NPR1), ELISA Kit

Also Known As

Canine Atrial natriuretic peptide receptor 1 (NPR1) ELISA Kit

Product Gene Name
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
Request for Current Manual Insert
OMIM
108960
Species Reactivity
Samples
Serum, plasma, Cell Culture Supernatants, body fluid and tissue homogenate
Preparation and Storage
Store all reagents at 2-8 degree C.
Sample Preparation
We suggest pre-experimenting with neat (undiluted) samples, 1:2 or 1:4 dilutions. Please avoid diluting your samples more than 1:10 as it would exceed the dilution limit set for this kit. If the expected concentration of the target is beyond the detection range of the kit, please contact our technical support team
Product Note
Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual.
Other Notes
Small volumes of NPR1 elisa kit vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Searchable Terms forNPR1purchase
MBS7241665 is a ready-to-use microwell, strip plate ELISA (enzyme-linked immunosorbent assay) Kit for analyzing the presence of the Atrial natriuretic peptide receptor 1 (NPR1) ELISA Kit target analytes in biological samples. The concentration gradients of the kit standards or positive controls render a theoretical kit detection range in biological research samples containing NPR1. The ELISA analytical biochemical technique of the MBS7241665 kit is based on NPR1 antibody-NPR1 antigen interactions (immunosorbency) and an HRP colorimetric detection system to detect NPR1 antigen targets in samples. The ELISA Kit is designed to detect native, not recombinant, NPR1. Appropriate sample types may include undiluted body fluids and/or tissue homogenates, secretions. Quality control assays assessing reproducibility identified the intra-assay CV (%) and inter-assay CV(%).
Product Categories/Family for NPR1 elisa kit
NCBI/Uniprot data below describe general gene information for NPR1. It may not necessarily be applicable to this product.
NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
118,919 Da
NCBI Official Full Name
atrial natriuretic peptide receptor 1
NCBI Official Synonym Full Names
natriuretic peptide receptor 1
NCBI Official Symbol
NCBI Official Synonym Symbols
ANPa; NPRA; ANPRA; GUC2A; GUCY2A
  [Similar Products]
NCBI Protein Information
atrial natriuretic peptide receptor 1; GC-A; ANP-A; NPR-A; ANPR-A; guanylate cyclase A; natriuretic peptide receptor A; atrionatriuretic peptide receptor A; natriuretic peptide A type receptor; atrial natriuretic peptide receptor type A; natriuretic peptide receptor A/guanylate cyclase A (atrionatriuretic peptide receptor A)
UniProt Protein Name
Atrial natriuretic peptide receptor 1
UniProt Synonym Protein Names
Atrial natriuretic peptide receptor type A; ANP-A; ANPR-A; NPR-A; Guanylate cyclase A; GC-A
UniProt Gene Name
UniProt Synonym Gene Names
ANPRA; ANP-A; ANPR-A; NPR-A; GC-A  [Similar Products]
UniProt Entry Name
ANPRA_HUMAN
NCBI Summary for NPR1
Guanylyl cyclases, catalyzing the production of cGMP from GTP, are classified as soluble and membrane forms (Garbers and Lowe, 1994 [PubMed 7982997]). The membrane guanylyl cyclases, often termed guanylyl cyclases A through F, form a family of cell-surface receptors with a similar topographic structure: an extracellular ligand-binding domain, a single membrane-spanning domain, and an intracellular region that contains a protein kinase-like domain and a cyclase catalytic domain. GC-A and GC-B function as receptors for natriuretic peptides; they are also referred to as atrial natriuretic peptide receptor A (NPR1) and type B (NPR2; MIM 108961). Also see NPR3 (MIM 108962), which encodes a protein with only the ligand-binding transmembrane and 37-amino acid cytoplasmic domains. NPR1 is a membrane-bound guanylate cyclase that serves as the receptor for both atrial and brain natriuretic peptides (ANP (MIM 108780) and BNP (MIM 600295), respectively).[supplied by OMIM, May 2009]
UniProt Comments for NPR1
ANPA: natriuretic peptide receptor A, which mediates natriuretic, diuretic, and vasorelaxing actions of the natriuretic peptides. Contains five functional domains: an extracellular ligand-binding domain, a single membrane-spanning region, and intracellularly a protein kinase homology domain, a helical hinge region involved in oligomerization, and a carboxyl-terminal guanylyl cyclase catalytic domain. Belongs to the adenylyl cyclase class-4/guanylyl cyclase family. Has guanylate cyclase activity on binding of ANF. Hypertensive SHR Rat has polymorphism at the locus. Human non-coding polymorphisms can alter expression up to two-fold, and have been associated with hypertension. A coding SNP is associated with hypertension and myocardial infarction.

Protein type: Kinase, protein; EC 4.6.1.2; Protein kinase, dual-specificity (receptor); Lyase; Nucleotide Metabolism - purine; Guanylyl cyclase; Protein kinase, RGC; Membrane protein, integral; Receptor, misc.; RGC group; RGC family

Chromosomal Location of Human Ortholog: 1q21-q22

Cellular Component: integral to plasma membrane; receptor complex

Molecular Function: guanylate cyclase activity; hormone binding; GTP binding; natriuretic peptide receptor activity; peptide hormone binding; peptide receptor activity, G-protein coupled; protein kinase binding; ATP binding; protein kinase activity

Biological Process: cGMP biosynthetic process; negative regulation of smooth muscle cell proliferation; regulation of vasodilation; body fluid secretion; protein amino acid phosphorylation; dopamine metabolic process; G-protein coupled receptor protein signaling pathway; negative regulation of angiogenesis; cell surface receptor linked signal transduction; positive regulation of cGMP biosynthetic process; receptor guanylyl cyclase signaling pathway; regulation of blood pressure; negative regulation of cell growth; regulation of vascular permeability; regulation of blood vessel size
Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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