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Nr1h4 elisa kit :: Rat Bile acid receptor ELISA Kit

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Catalog # MBS9428045
Unit / Price
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  96 Tests  /  $575 +1 FREE 8GB USB
Nr1h4 elisa kit
Product Name

Bile acid receptor (Nr1h4), ELISA Kit

Full Product Name

Rat Bile acid receptor ELISA Kit

Product Synonym Names
Bile acid receptor; Farnesoid X-activated receptor; Farnesol receptor HRR-1; Nuclear receptor subfamily 1 group H member 4; Retinoid X receptor-interacting protein 14; RXR-interacting protein
Product Gene Name
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
Request for Current Manual Insert
3D Structure
ModBase 3D Structure for Q62735
Species Reactivity
Samples
Serum, plasma, tissue homogenates and other biological fluids.
Detection Range
78-5000 pg/mL
Assay Time
3-5h
Sample Volume
100T
Detection Wavelength
450 nm
Preparation and Storage
Store at 4 degree C
Product Note
Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual.
Other Notes
Small volumes of Nr1h4 elisa kit vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Searchable Terms for Nr1h4purchase
MBS9428045 is a ready-to-use microwell, strip-or-full plate ELISA (enzyme-linked immunosorbent assay) Kit for analyzing the presence of the Bile acid receptor (Nr1h4) ELISA Kit target analytes in biological samples. The concentration gradients of the kit standards or positive controls render a theoretical kit detection range in biological research samples containing Nr1h4. The ELISA analytical biochemical technique of the MBS9428045 kit is based on Nr1h4 antibody-Nr1h4 antigen interactions (immunosorbency) and an HRP colorimetric detection system to detect Nr1h4 antigen targets in samples. The ELISA Kit is designed to detect native, not recombinant, Nr1h4. Appropriate sample types may include undiluted body fluids and/or tissue homogenates, secretions. Quality control assays assessing reproducibility identified the intra-assay CV (%) and inter-assay CV(%).
NCBI/Uniprot data below describe general gene information for Nr1h4. It may not necessarily be applicable to this product.
NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
UniProt Primary Accession #
UniProt Related Accession #
Molecular Weight
53,935 Da
NCBI Official Full Name
bile acid receptor
NCBI Official Synonym Full Names
nuclear receptor subfamily 1, group H, member 4
NCBI Official Symbol
Nr1h4  [Similar Products]
NCBI Official Synonym Symbols
NCBI Protein Information
bile acid receptor
UniProt Protein Name
Bile acid receptor
UniProt Synonym Protein Names
Farnesoid X-activated receptor; Farnesol receptor HRR-1; Nuclear receptor subfamily 1 group H member 4; Retinoid X receptor-interacting protein 14; RXR-interacting protein 14
Protein Family
UniProt Gene Name
Nr1h4  [Similar Products]
UniProt Synonym Gene Names
Bar; Fxr; Rip14; RXR-interacting protein 14  [Similar Products]
NCBI Summary for Nr1h4
nuclear hormone receptor that is activated by farnesol metabolites [RGD, Feb 2006]
UniProt Comments for Nr1h4
NR1H4: Ligand-activated transcription factor. Receptor for bile acids such as chenodeoxycholic acid, lithocholic acid and deoxycholic acid. Represses the transcription of the cholesterol 7-alpha-hydroxylase gene (CYP7A1) through the induction of NR0B2 or FGF19 expression, via two distinct mechanisms. Activates the intestinal bile acid-binding protein (IBABP). Activates the transcription of bile salt export pump ABCB11 by directly recruiting histone methyltransferase CARM1 to this locus. Heterodimer of NR1H4 and RXR. After activation by agonist binding, interacts with a coactivator, NCOA1 or NCOA2. Interacts with CARM1 and SMARD1. Belongs to the nuclear hormone receptor family. NR1 subfamily. 4 isoforms of the human protein are produced by alternative splicing.

Protein type: DNA-binding; Nuclear receptor

Chromosomal Location of Human Ortholog: 7q13

Cellular Component: nucleus

Molecular Function: bile acid binding; DNA binding; double-stranded DNA binding; ligand-dependent nuclear receptor activity; peptide binding; receptor activity; retinoid X receptor binding; RNA polymerase II transcription factor activity, enhancer binding; sequence-specific DNA binding; steroid hormone receptor activity; transcription factor activity

Biological Process: bile acid metabolic process; defense response to bacterium; fatty acid homeostasis; glucose homeostasis; gut development; inhibition of NF-kappaB transcription factor; intercellular junction assembly; intracellular receptor-mediated signaling pathway; negative regulation of apoptosis; negative regulation of I-kappaB kinase/NF-kappaB cascade; negative regulation of inflammatory response; negative regulation of interferon-gamma production; negative regulation of interleukin-1 production; negative regulation of interleukin-2 production; negative regulation of interleukin-6 production; negative regulation of transcription from RNA polymerase II promoter; negative regulation of tumor necrosis factor production; Notch signaling pathway; positive regulation of insulin receptor signaling pathway; positive regulation of transcription from RNA polymerase II promoter; regulation of carbohydrate metabolic process; regulation of transcription from RNA polymerase II promoter; regulation of transcription, DNA-dependent; response to glucose stimulus; response to lipopolysaccharide; toll-like receptor 4 signaling pathway; toll-like receptor 9 signaling pathway
Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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