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NR3C1 cdna clone

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Catalog # MBS1277215
Unit / Price
  0.01 mg Plasmid + 0.2 mL Glycerol-Stock  /  $165 +1 FREE 8GB USB
NR3C1 cdna clone
Product Name

NR3C1, cDNA Clone

Popular Item
Also Known As

NR3C1 cDNA Clone

Product Gene Name
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
Sequence Length
2334
Sequence
atggactcca aagaatcatt aactcctggt agagaagaaa accccagcag tgtgcttgct caggagaggg gagatgtgat ggacttctat aaaaccctaa gaggaggagc tactgtgaag gtttctgcgt cttcaccctc actggctgtc gcttctcaat cagactccaa gcagcgaaga cttttggttg attttccaaa aggctcagta agcaatgcgc agcagccaga tctgtccaaa gcagtttcac tctcaatggg actgtatatg ggagagacag aaacaaaagt gatgggaaat gacctgggat tcccacagca gggccaaatc agcctttcct cgggggaaac agacttaaag cttttggaag aaagcattgc aaacctcaat aggtcgacca gtgttccaga gaaccccaag agttcagcat ccactgctgt gtctgctgcc cccacagaga aggagtttcc aaaaactcac tctgatgtat cttcagaaca gcaacatttg aagggccaga ctggcaccaa cggtggcaat gtgaaattgt ataccacaga ccaaagcacc tttgacattt tgcaggattt ggagttttct tctgggtccc caggtaaaga gacgaatgag agtccttgga gatcagacct gttgatagat gaaaactgtt tgctttctcc tctggcggga gaagacgatt cattcctttt ggaaggaaac tcgaatgagg actgcaagcc tctcatttta ccggacacta aacccaaaat taaggataat ggagatctgg ttttgtcaag ccccagtaat gtaacactgc cccaagtgaa aacagaaaaa gaagatttca tcgaactctg cacccctggg gtaattaagc aagagaaact gggcacagtt tactgtcagg caagctttcc tggagcaaat ataattggta ataaaatgtc tgccatttct gttcatggtg tgagtacctc tggaggacag atgtaccact atgacatgaa tacagcatcc ctttctcaac agcaggatca gaagcctatt tttaatgtca ttccaccaat tcccgttggt tccgaaaatt ggaataggtg ccaaggatct ggagatgaca acttgacttc tctggggact ctgaacttcc ctggtcgaac agttttttct aatggctatt caagccccag catgagacca gatgtaagct ctcctccatc cagctcctca acagcaacaa caggaccacc tcccaaactc tgcctggtgt gctctgatga agcttcagga tgtcattatg gagtcttaac ttgtggaagc tgtaaagttt tcttcaaaag agcagtggaa ggacagcaca attacctatg tgctggaagg aatgattgca tcatcgataa aattcgaaga aaaaactgcc cagcatgccg ctatcgaaaa tgtcttcagg ctggaatgaa cctggaagct cgaaaaacaa agaaaaaaat aaaaggaatt cagcaggcca ctacaggagt ctcacaagaa acctctgaaa atcctggtaa caaaacaata gttcctgcaa cgttaccaca actcacccct accctggtgt cactgttgga ggttattgaa cctgaagtgt tatatgcagg atatgatagc tctgttccag actcaacttg gaggatcatg actacgctca acatgttagg agggcggcaa gtgattgcag cagtgaaatg ggcaaaggca ataccaggtt tcaggaactt acacctggat gaccaaatga ccctactgca gtactcctgg atgtttctta tggcatttgc tctggggtgg agatcatata gacaatcaag tgcaaacctg ctgtgttttg ctcctgatct gattattaat gagcagagaa tgactctacc ctgcatgtac gaccaatgta aacacatgct gtatgtttcc tctgagttac acaggcttca ggtatcttat gaagagtatc tctgtatgaa aaccttactg cttctctctt cagttcctaa ggacggtctg aagagccaag agctatttga tgaaattaga atgacctaca tcaaagagct aggaaaagcc attgtcaaga gggaaggaaa ctccagccag aactggcagc ggttttatca actgacaaaa ctcttggatt ctatgcatga agtggttgaa aatctcctta actattgctt ccaaacattt ttggataaga ccatgagtat tgaattcccc gagatgttag ctgaaatcat caccaatcag ataccaaaat attcaaatgg aaatatcaaa aaacttctgt ttcatcaaaa gtga
OMIM
138040
Vector
pENTR223.1
Clone Sequence Report
Provided with product shipment
ISO Certification
Manufactured in an ISO 9001:2008 Certified Laboratory.
Other Notes
Small volumes of NR3C1 cdna clone vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
NCBI/Uniprot data below describe general gene information for NR3C1. It may not necessarily be applicable to this product.
NCBI GI #
NCBI GeneID
NCBI Accession #
UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
49,802 Da
NCBI Official Full Name
Homo sapiens nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor), mRNA
NCBI Official Synonym Full Names
nuclear receptor subfamily 3 group C member 1
NCBI Official Symbol
NR3C1  [Similar Products]
NCBI Official Synonym Symbols
GR; GCR; GRL; GCCR; GCRST
  [Similar Products]
NCBI Protein Information
glucocorticoid receptor
UniProt Protein Name
Glucocorticoid receptor
UniProt Synonym Protein Names
Nuclear receptor subfamily 3 group C member 1
Protein Family
UniProt Gene Name
NR3C1  [Similar Products]
UniProt Synonym Gene Names
GRL; GR  [Similar Products]
UniProt Entry Name
GCR_HUMAN
NCBI Summary for NR3C1
This gene encodes glucocorticoid receptor, which can function both as a transcription factor that binds to glucocorticoid response elements in the promoters of glucocorticoid responsive genes to activate their transcription, and as a regulator of other transcription factors. This receptor is typically found in the cytoplasm, but upon ligand binding, is transported into the nucleus. It is involved in inflammatory responses, cellular proliferation, and differentiation in target tissues. Mutations in this gene are associated with generalized glucocorticoid resistance. Alternative splicing of this gene results in transcript variants encoding either the same or different isoforms. Additional isoforms resulting from the use of alternate in-frame translation initiation sites have also been described, and shown to be functional, displaying diverse cytoplasm-to-nucleus trafficking patterns and distinct transcriptional activities (PMID:15866175). [provided by RefSeq, Feb 2011]
UniProt Comments for NR3C1
GR: transcription factor of the nuclear receptor family. Receptor for glucocorticoids (GC). Binds to glucocorticoid response elements (GRE) and modulates other transcription factors. Affects inflammatory responses, cellular proliferation and differentiation in target tissues. Three alternatively spliced isoforms have been described.

Protein type: Transcription factor; DNA-binding; Nuclear receptor; Mitochondrial

Chromosomal Location of Human Ortholog: 5q31.3

Cellular Component: cytoplasm; mitochondrial matrix; nucleoplasm; nucleus; protein complex

Molecular Function: glucocorticoid receptor activity; protein binding; protein complex binding; steroid binding; transcription factor activity

Biological Process: positive regulation of transcription from RNA polymerase II promoter; regulation of transcription, DNA-dependent; signal transduction; transcription from RNA polymerase II promoter; transcription initiation from RNA polymerase II promoter; transcription, DNA-dependent

Disease: Glucocorticoid Resistance, Generalized
Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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