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anti-NRF1 antibody :: Rabbit NRF1 Antibody

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Catalog # MBS003165
Unit / Price
  0.05 mL  /  $270 +1 FREE 8GB USB
  0.1 mL  /  $445 +1 FREE 8GB USB
Western Blot
Product Name

NRF1, Antibody

Popular Item
Also Known As

Rabbit NRF1 Antibody

Product Synonym Names
Nuclear respiratory factor 1; NRF-1; Alpha palindromic-binding protein; Alpha-pal; NRF1
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
Immunogen Sequence Length
503
Chromosome Location
Chromosome: 7; NC_000007.13 (129251555..129396922). Location: 7q32
OMIM
600879
3D Structure
ModBase 3D Structure for Q16656
Isotype
IgG
Host
Rabbit
Species Reactivity
Human (Identities = 100%, Positives = 100%);
Mouse (Identities = 100%, Positives = 100%);
Rat (Identities = 100%, Positives = 100%)
Specificity
NRF1 antibody detects endogenous levels of total NRF1 protein.
Purity/Purification
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Form/Format
Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Concentration
1 mg/ml (lot specific)
Immunogen
The antiserum was produced against synthesized peptide derived from internal of human NRF1.
Preparation and Storage
Store at -20 Degree C/1 year
Other Notes
Small volumes of anti-NRF1 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Applications Tested/Suitable for anti-NRF1 antibody
ELISA (EIA), Western Blot (WB)
Application Notes for anti-NRF1 antibody
WB: 1:500~1:3000
ELISA: 1:1000

Western Blot of anti-NRF1 antibody
Western blot analysis of extracts from 3T3 cells, using NRF1 antibody.
anti-NRF1 antibody Western Blot (WB) image
NCBI/Uniprot data below describe general gene information for NRF1. It may not necessarily be applicable to this product.
NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
UniProt Primary Accession #
UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
53,541 Da
NCBI Official Full Name
nuclear respiratory factor 1
NCBI Official Synonym Full Names
nuclear respiratory factor 1
NCBI Official Symbol
NCBI Official Synonym Symbols
ALPHA-PAL
  [Similar Products]
NCBI Protein Information
nuclear respiratory factor 1; NRF-1; alpha palindromic-binding protein
UniProt Protein Name
Nuclear respiratory factor 1
UniProt Synonym Protein Names
Alpha palindromic-binding protein
UniProt Gene Name
UniProt Synonym Gene Names
NRF-1; Alpha-pal  [Similar Products]
UniProt Entry Name
NRF1_HUMAN
NCBI Summary for NRF1
This gene encodes a protein that homodimerizes and functions as a transcription factor which activates the expression of some key metabolic genes regulating cellular growth and nuclear genes required for respiration, heme biosynthesis, and mitochondrial DNA transcription and replication. The protein has also been associated with the regulation of neurite outgrowth. Alternate transcriptional splice variants, which encode the same protein, have been characterized. Additional variants encoding different protein isoforms have been described but they have not been fully characterized. Confusion has occurred in bibliographic databases due to the shared symbol of NRF1 for this gene and for "nuclear factor (erythroid-derived 2)-like 1" which has an official symbol of NFE2L1. [provided by RefSeq, Jul 2008]
UniProt Comments for NRF1
NRF1: Transcription factor that activates the expression of the EIF2S1 (EIF2-alpha) gene. Links the transcriptional modulation of key metabolic genes to cellular growth and development. Implicated in the control of nuclear genes required for respiration, heme biosynthesis, and mitochondrial DNA transcription and replication. Belongs to the NRF1/Ewg family. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: DNA-binding; Transcription factor

Chromosomal Location of Human Ortholog: 7q32

Cellular Component: nucleoplasm; cytoplasm

Biological Process: regulation of transcription from RNA polymerase II promoter; mitochondrion organization and biogenesis; organ regeneration; generation of precursor metabolites and energy; transcription, DNA-dependent; response to folic acid; organelle organization and biogenesis; response to hypoxia; positive regulation of transcription from RNA polymerase II promoter; response to lipopolysaccharide; cellular lipid metabolic process; response to electrical stimulus; response to estradiol stimulus
Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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