AAF28849.1
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UniProt Primary Accession #
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UniProt Related Accession #
Molecular Weight
91,679 Da
NCBI Official Full Name
neuregulin 2 isoform 2
NCBI Official Synonym Full Names
neuregulin 2
NCBI Protein Information
pro-neuregulin-2, membrane-bound isoform; pro-NRG2; divergent of neuregulin-1; neural- and thymus-derived activator for ErbB kinases
UniProt Protein Name
Pro-neuregulin-2, membrane-bound isoform
UniProt Synonym Protein Names
Divergent of neuregulin-1; DON-1; Neural- and thymus-derived activator for ERBB kinases
UniProt Synonym Gene Names
UniProt Entry Name
NRG2_HUMAN
NCBI Summary for NRG2
This gene encodes a novel member of the neuregulin family of growth and differentiation factors. Through interaction with the ERBB family of receptors, this protein induces the growth and differentiation of epithelial, neuronal, glial, and other types of cells. The gene consists of 12 exons and the genomic structure is similar to that of neuregulin 1, another member of the neuregulin family of ligands. The products of these genes mediate distinct biological processes by acting at different sites in tissues and eliciting different biological responses in cells. This gene is located close to the region for demyelinating Charcot-Marie-Tooth disease locus, but is not responsible for this disease. Alternative transcript variants encoding distinct isoforms have been described. [provided by RefSeq, May 2010]
UniProt Comments for NRG2
NRG2: Direct ligand for ERBB3 and ERBB4 tyrosine kinase receptors. Concomitantly recruits ERBB1 and ERBB2 coreceptors, resulting in ligand-stimulated tyrosine phosphorylation and activation of the ERBB receptors. May also promote the heterodimerization with the EGF receptor. Belongs to the neuregulin family. 8 isoforms of the human protein are produced by alternative splicing.
Protein type: Membrane protein, integral; Ligand, receptor tyrosine kinase
Chromosomal Location of Human Ortholog: 5q31.2
Cellular Component: extracellular space; extracellular region; integral to membrane; plasma membrane
Molecular Function: growth factor activity; receptor binding
Biological Process: epidermal growth factor receptor signaling pathway; embryonic development; phosphoinositide-mediated signaling; fibroblast growth factor receptor signaling pathway; nerve growth factor receptor signaling pathway; organ development; innate immune response; signal transduction
Research Articles on NRG2
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Products associated with NRG2 elisa kit
Pathways associated with NRG2 elisa kit
Diseases associated with NRG2 elisa kit
Organs/Tissues associated with NRG2 elisa kit
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