P01161.1
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UniProt Primary Accession #
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UniProt Related Accession #
Molecular Weight
Predicted Molecular Mass: 12.9kDa Accurate Molecular Mass: 17kDa as determined by SDS-PAGE reducing conditions.
NCBI Official Full Name
Natriuretic peptides A
NCBI Official Synonym Full Names
natriuretic peptide A
NCBI Protein Information
natriuretic peptides A
UniProt Protein Name
Natriuretic peptides A
UniProt Synonym Protein Names
Prepronatriodilatin
UniProt Synonym Gene Names
NCBI Summary for NT-ProANP
peptide involved in the control of fluid volume and vascular function [RGD, Feb 2006]
UniProt Comments for NT-ProANP
NPPA: Hormone playing a key role in cardiovascular homeostasis through regulation of natriuresis, diuresis, and vasodilation. Also plays a role in female pregnancy by promoting trophoblast invasion and spiral artery remodeling in uterus. Specifically binds and stimulates the cGMP production of the NPR1 receptor. Binds the clearance receptor NPR3. Defects in NPPA are the cause of familial atrial fibrillation type 6 (ATFB6). Atrial fibrillation is a common disorder of cardiac rhythm that is hereditary in a small subgroup of patients. It is characterized by disorganized atrial electrical activity, progressive deterioration of atrial electromechanical function and ineffective pumping of blood into the ventricles. It can be associated with palpitations, syncope, thromboembolic stroke, and congestive heart failure. Belongs to the natriuretic peptide family.
Protein type: Hormone; Secreted; Secreted, signal peptide
Research Articles on NT-ProANP
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