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NT3 recombinant protein

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Catalog # MBS538197
Unit / Price
  0.002 mg  /  $180 +1 FREE 8GB USB
  0.01 mg  /  $310 +1 FREE 8GB USB
NT3 recombinant protein
Product Name

NT3, Recombinant Protein

Also Known As

NT3 protein

Product Synonym Names
NGF-2 protein; HGNF protein; NT-3 protein; Neurotrophic factor protein; NT 3; Neurotrophin-3 protein; NT 3 protein; Nerve growth factor-2 protein; NT3; NT-3
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
Sequence Length
257
Sequence
Region of NT3 protein correspond ing to amino acids MYAEHKSHRG EYSVCDSESL WVTDKSSAID IRGHQVTVLG EIKTGNSPVK QYFYETRCKE ARPVKNGCRG IDDKHWNSQC KTSQTYVRAL TSENNKLVGW RWIRIDTSCV CALSRKIGRT .
OMIM
162660
3D Structure
ModBase 3D Structure for P20783
Host
Human
Purity/Purification
> 98% pure
Form/Format
Supplied lyophilized with no additives. Reconstitute in water to a concentration of 0.1-1.0 mg/ml. Allow to set for at least 30 minutes, mix well.
Protein Type
Recombinant
Biological Significance
NT-3 is a neurotrophic factor structurally related to beta-NGF, BDNF, and NT-4. These proteins belong to the cysteine-knot family of growth factors that assume stable dimeric structures. NT-3 is expressed by neurons of the central nervous systems and can signal through the trk receptors. NT-3 promotes the growth and survival of nerve and glial cells. The amino acid sequences of human, Mouse and rat NT-3 are identical.
Bioactivity
The ED50 as determined by the dose-dependent induction of choline acetyl transferase activity in rat basal forebrain primary septal cell cultures was found to be in the range of 20-50 ng/ml.
Endotoxin Levels
Endotoxin level is less than 0.1 ng per ug (1 EU/ug).
Expression System
E Coli
Preparation and Storage
Store at 4 degree C until reconstitution. Following reconstitution aliquot and freeze at -20 degree C for long term storage. Avoid repeated freeze/thaw cycles.
Other Notes
Small volumes of NT3 recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Related Product Information for
NT3 recombinant protein
Purified recombinant Human NT3 protein
Product Categories/Family for NT3 recombinant protein
Applications Tested/Suitable for NT3 recombinant protein
User optimized
NCBI/Uniprot data below describe general gene information for NT3. It may not necessarily be applicable to this product.
NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
UniProt Primary Accession #
UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
13.6 kDa
NCBI Official Full Name
neurotrophin-3 isoform 2 preproprotein
NCBI Official Synonym Full Names
neurotrophin 3
NCBI Official Symbol
NCBI Official Synonym Symbols
NT3; HDNF; NGF2; NT-3; NGF-2
  [Similar Products]
NCBI Protein Information
neurotrophin-3
UniProt Protein Name
Neurotrophin-3
UniProt Synonym Protein Names
HDNF; Nerve growth factor 2; NGF-2; Neurotrophic factor
UniProt Gene Name
UniProt Synonym Gene Names
NT-3; NGF-2  [Similar Products]
UniProt Entry Name
NTF3_HUMAN
NCBI Summary for NT3
The protein encoded by this gene is a member of the neurotrophin family, that controls survival and differentiation of mammalian neurons. This protein is closely related to both nerve growth factor and brain-derived neurotrophic factor. It may be involved in the maintenance of the adult nervous system, and may affect development of neurons in the embryo when it is expressed in human placenta. NTF3-deficient mice generated by gene targeting display severe movement defects of the limbs. The mature peptide of this protein is identical in all mammals examined including human, pig, rat and mouse. [provided by RefSeq, Jul 2008]
UniProt Comments for NT3
NT-3: Seems to promote the survival of visceral and proprioceptive sensory neurons. Belongs to the NGF-beta family. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Secreted, signal peptide; Secreted; Cytokine

Chromosomal Location of Human Ortholog: 12p13

Cellular Component: cytoplasmic membrane-bound vesicle; extracellular region

Molecular Function: neurotrophin p75 receptor binding; growth factor activity; nerve growth factor binding; chemoattractant activity; receptor binding

Biological Process: myelination; axon guidance; epidermis development; mechanoreceptor differentiation; glial cell fate determination; activation of MAPK activity; regulation of neuron differentiation; positive regulation of receptor internalization; positive regulation of glial cell differentiation; signal transduction; enteric nervous system development; induction of positive chemotaxis; cell-cell signaling; positive chemotaxis; positive regulation of cell proliferation; negative regulation of neuron apoptosis; regulation of synaptic transmission; nervous system development; negative regulation of peptidyl-tyrosine phosphorylation; activation of protein kinase B; positive regulation of peptidyl-serine phosphorylation; peripheral nervous system development; positive regulation of peptidyl-tyrosine phosphorylation; neuromuscular synaptic transmission; positive regulation of transcription from RNA polymerase II promoter; smooth muscle cell differentiation; nerve development; brain development; transmembrane receptor protein tyrosine kinase signaling pathway; neurite morphogenesis; positive regulation of cell migration
Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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