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NUP98 recombinant protein :: Nucleoporin 98kDa (NUP98) Recombinant Protein

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Catalog # MBS2018370 (SPECIAL PROMOTION: Get FREE $5 Starbucks gift card (Maximum 5 gift cards/product). Gift card(s) will be included with shipment)
Unit / Price
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  0.01 mg  /  $145 +1 FREE 8GB USB
  0.05 mg  /  $275 +1 FREE 8GB USB
  0.1 mg  /  $430 +1 FREE 8GB USB
  0.2 mg  /  $525 +1 FREE 8GB USB
  0.5 mg  /  $1,015 +1 FREE 8GB USB
  1 mg  /  $1,515 +1 FREE 8GB USB
Product Name

Nucleoporin 98kDa (NUP98), Recombinant Protein

Popular Item
Full Product Name

Recombinant Nucleoporin 98kDa (NUP98)

Matching Pairs
Matching Pairs
Matching Pairs
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
MBS2018370 Technical Datasheet
Chromosome Location
Chromosome: 11; NC_000011.9 (3696240..3819022, complement). Location: 11p15.5
OMIM
601021
3D Structure
ModBase 3D Structure for P52948
Host
E. coli
Species Reactivity
Homo sapiens (Human)
Purity/Purification
> 90%
Form/Format
100mM NaHCO3, 500mM NaCl, pH8.3, containing 1mM DTT, 0.01% SKL, 5% Trehalose and Proclin300
Concentration
Original Concentration: 200 ug/mL (lot specific)
Organism Species
Homo sapiens (Human)
Source
Prokaryotic expression
Residues
Gln629~Pro894
Tags
N-terminal His Tag
Subcellular Location
Nucleus
Traits
Freeze-dried powder
Buffer formulation
100mMNaHCO3, 500mMNaCl, pH8.3, containing 1mM DTT, 0.01% SKL, 5% Trehalose and Proclin300.
Predicted isoelectric point
5.5
Predicted Molecular Mass
33.5kDa
Accurate Molecular Mass
34kDa as determined by SDS-PAGE reducing conditions.
USAGE
Reconstitute in 100mM NaHCO3, 500mM NaCl (pH8.3) to a concentration of 0.1-1.0 mg/mL. Do not vortex.
Preparation and Storage
Storage: Avoid repeated freeze/thaw cycles.
Store at 2-8ºC for one month.
Aliquot and store at -80ºC for 12 months.

Stability Test: The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37°C for 48h, and no obvious degradation and precipitation were observed. The loss rate is less than 5% within the expiration date under appropriate storage condition.
ISO Certification
Manufactured in an ISO 9001:2008 and ISO 13485:2003 Certified Laboratory.
Supply Chain Verification
Manufactured in a lab with traceable raw materials. Bulk orders can typically be prepared to the customer’s specifications, please inquire.
Other Notes
Small volumes of NUP98 recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Applications Tested/Suitable for NUP98 recombinant protein
Positive Control, Immunogen, SDS-PAGE, WB.
(May be suitable for use in other assays to be determined by the end user.)

Sequence Information of NUP98 recombinant protein
NUP98 recombinant protein Sequence Information image
NCBI/Uniprot data below describe general gene information for NUP98. It may not necessarily be applicable to this product.
NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
UniProt Primary Accession #
UniProt Secondary Accession #
UniProt Related Accession #
NCBI Official Full Name
nuclear pore complex protein Nup98-Nup96 isoform 3
NCBI Official Synonym Full Names
nucleoporin 98kDa
NCBI Official Symbol
NUP98  [Similar Products]
NCBI Official Synonym Symbols
ADIR2; NUP96; NUP196
  [Similar Products]
NCBI Protein Information
nuclear pore complex protein Nup98-Nup96; GLFG-repeat containing nucleoporin
UniProt Protein Name
Nuclear pore complex protein Nup98-Nup96
UniProt Synonym Protein Names
98 kDa nucleoporin; Nucleoporin Nup98; Nup98Nuclear pore complex protein Nup96; Alternative name(s):; 96 kDa nucleoporin; Nucleoporin Nup96
UniProt Gene Name
NUP98  [Similar Products]
UniProt Synonym Gene Names
ADAR2; Nup98; Nup96  [Similar Products]
UniProt Entry Name
NUP98_HUMAN
NCBI Summary for NUP98
Signal-mediated nuclear import and export proceed through the nuclear pore complex (NPC), which is comprised of approximately 50 unique proteins collectively known as nucleoporins. The 98 kDa nucleoporin is generated through a biogenesis pathway that involves synthesis and proteolytic cleavage of a 186 kDa precursor protein. This cleavage results in the 98 kDa nucleoporin as well as a 96 kDa nucleoporin, both of which are localized to the nucleoplasmic side of the NPC. Rat studies show that the 98 kDa nucleoporin functions as one of several docking site nucleoporins of transport substrates. The human gene has been shown to fuse to several genes following chromosome translocations in acute myelogenous leukemia (AML) and T-cell acute lymphocytic leukemia (T-ALL). This gene is one of several genes located in the imprinted gene domain of 11p15.5, an important tumor-suppressor gene region. Alterations in this region have been associated with the Beckwith-Wiedemann syndrome, Wilms tumor, rhabdomyosarcoma, adrenocortical carcinoma, and lung, ovarian, and breast cancer. Alternative splicing of this gene results in several transcript variants; however, not all variants have been fully described. [provided by RefSeq, May 2010]
UniProt Comments for NUP98
NUP98: Nup98 and Nup96 play a role in the bidirectional transport across the nucleoporin complex (NPC). The repeat domain in Nup98 has a direct role in the transport. Nup98 interacts directly with Nup96. Nup96 is part of the Nup160 subcomplex in the nuclear pore which is composed of Nup160, Nup133, Nup107 and Nup96. This complex plays a role in RNA export and in tethering Nup98 and Nup153 to the nucleus. May interact with RAE1. Interacts with vesicular stomatitis virus protein M. Belongs to the nucleoporin GLFG family. 6 isoforms of the human protein are produced by alternative splicing.

Protein type: Motility/polarity/chemotaxis; Nucleoporin

Chromosomal Location of Human Ortholog: 11p15.5

Cellular Component: nucleoplasm; kinetochore; nuclear membrane; nuclear pore; nuclear envelope; cytosol; nuclear inclusion body

Molecular Function: protein binding; structural constituent of nuclear pore; transporter activity; peptide binding

Biological Process: nuclear pore complex assembly; mRNA transport; viral reproduction; cytokine and chemokine mediated signaling pathway; protein import into nucleus, docking; mitotic nuclear envelope disassembly; nucleocytoplasmic transport; pathogenesis; viral infectious cycle; glucose transport; nuclear pore organization and biogenesis; hexose transport; carbohydrate metabolic process; gene expression; viral transcription; mitotic cell cycle; DNA replication; transmembrane transport
Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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