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anti-OCT-2 antibody :: Rabbit OCT-2 Antibody

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Catalog # MBS462094
Unit / Price
  0.1 mg  /  $245 +1 FREE 8GB USB
Testing Data
Product Name

OCT-2, Antibody

Also Known As

Rabbit anti OCT-2 antibody

Product Synonym Names
Rabbit anti-Oct-2; POU2F2
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
Chromosome Location
Chromosome: 19; NC_000019.9 (42592650..42636630, complement). Location: 19q13.2
OMIM
164176
3D Structure
ModBase 3D Structure for P09086
Host
Rabbit
Species Reactivity
Human, Mouse, Rat
Specificity
This antibody recognizes ~55 kDa of OCT-2 protein from human, rat and mouse origins. It does not cross react with OCT-1, OCT-4. The other species are not tested
Purity/Purification
The Rabbit IgG is purified by Epitope Affinity Purification.
Form/Format
This affinity purified antibody is supplied in sterile Phosphatebuffered saline (pH7.2) containing antibody stabilizer
Concentration
Size: 100 ug/200 ul (lot specific)
Antigen Preparation
A synthetic peptide corresponding to C-terminus of OCT-1 protein from human, mouse and rat origins.
Positive Control
Jurkat Cell Lysate
Preparation and Storage
The antibodies are stable for 12 months from date of receipt when stored at -20 degree C to -70 degree C. The antibodies can be stored at 2 degree C -8 degree C for three month without detectable loss of activity. Avoid repeated freezing-thawing cycles.
Other Notes
Small volumes of anti-OCT-2 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Related Product Information for
anti-OCT-2 antibody
Oct1 and Oct2 are transcription factors of the POU homeo-domain family that bind to the Ig gene octamer sites, regulating Bcell-specific genes. The function of these transcription factors is dependent on the activity of B-cell-restricted coactivators such as BOB.1/OBF.1.Absence of functional Oct-2 and Bob-1 cells represents a novel mechanism for immunoglobulin gene deregulation
Applications Tested/Suitable for anti-OCT-2 antibody
ELISA, Western Blot, Immunohistochemistry
Application Notes for anti-OCT-2 antibody
Western Blot: 0.1-1 ug/ml
ELISA: 0.01-0.1 ug/ml
Immunoprecipitation: 2-5 ug/ml
Immunohistochemistry: 0.5-2 ug/ml

Testing Data of anti-OCT-2 antibody
anti-OCT-2 antibody Testing Data image
NCBI/Uniprot data below describe general gene information for OCT-2. It may not necessarily be applicable to this product.
NCBI GI #
NCBI GeneID
UniProt Primary Accession #
UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
55 kDa
NCBI Official Full Name
Oct-2
NCBI Official Synonym Full Names
POU class 2 homeobox 2
NCBI Official Symbol
POU2F2  [Similar Products]
NCBI Official Synonym Symbols
OCT2; OTF2; Oct-2
  [Similar Products]
NCBI Protein Information
POU domain, class 2, transcription factor 2; OTF-2; homeobox protein; OTTHUMP00000231645; OTTHUMP00000231646; OTTHUMP00000231647; OTTHUMP00000231648; OTTHUMP00000231650; octamer-binding protein 2; octamer-binding transcription factor 2; lymphoid-restricted immunoglobulin octamer-binding protein NF-A2
UniProt Protein Name
POU domain, class 2, transcription factor 2
UniProt Synonym Protein Names
Lymphoid-restricted immunoglobulin octamer-binding protein NF-A2; Octamer-binding protein 2; Oct-2; Octamer-binding transcription factor 2
UniProt Gene Name
POU2F2  [Similar Products]
UniProt Synonym Gene Names
OCT2; OTF2  [Similar Products]
UniProt Entry Name
PO2F2_HUMAN
NCBI Summary for OCT-2
The protein encoded by this gene is a homeobox-containing transcription factor of the POU domain family. The encoded protein binds the octamer sequence 5'-ATTTGCAT-3', a common transcription factor binding site in immunoglobulin gene promoters. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2011]
UniProt Comments for OCT-2
Function: Transcription factor that specifically binds to the octamer motif (5'-ATTTGCAT-3'). Regulates transcription in a number of tissues in addition to activating immunoglobulin gene expression. Modulates transcription transactivation by NR3C1, AR and PGR. Isoform 5 activates the U2 small nuclear RNA (snRNA) promoter. Ref.2 Ref.6 Ref.8 Ref.9

Subunit structure: Interacts with NR3C1, AR and PGR. Ref.11

Subcellular location: Cytoplasm

By similarity. Nucleus.

Tissue specificity: Isoform 3 is B-cell specific. Isoform 5 is expressed in B-cells and the immunoglobulin-expressing T-cell line Molt-4, but not in the T-cell line BW 5147. Ref.2 Ref.10

Sequence similarities: Belongs to the POU transcription factor family. Class-2 subfamily.Contains 1 homeobox DNA-binding domain.Contains 1 POU-specific domain.

Sequence caution: The sequence CAA32039.1 differs from that shown. Reason: Erroneous initiation.
Product References and Citations for anti-OCT-2 antibody
Daniel Re, et al. Oct-2 and Bob-1 Deficiency in Hodgkin and Reed Sternberg Cells. Cancer Research 61, 2080-2084 (2001).

Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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