NP_598513.1
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NCBI GenBank Nucleotide #
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UniProt Primary Accession #
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UniProt Secondary Accession #
Molecular Weight
111,339 Da
NCBI Official Full Name
dynamin-like 120 kDa protein, mitochondrial isoform 2
UniProt Protein Name
Dynamin-like 120 kDa protein, mitochondrial
UniProt Synonym Protein Names
Large GTP-binding protein; LargeG; Optic atrophy protein 1 homologCleaved into the following chain:Dynamin-like 120 kDa protein, form S1
UniProt Synonym Gene Names
UniProt Entry Name
OPA1_MOUSE
UniProt Comments for OPA1
OPA1: a dynamin-related GTPase required for mitochondrial fusion and regulation of apoptosis. May form a diffusion barrier for proteins stored in mitochondrial cristae. Proteolytic processing in response to intrinsic apoptotic signals may lead to disassembly of OPA1 oligomers and release of the caspase activator cytochrome C (CYCS) into the mitochondrial intermembrane space. Defects in OPA1 are the cause of optic atrophy 1 and deafness. Eight splice-variant isoforms have been described.
Protein type: Mitochondrial; Apoptosis; Membrane protein, integral; Hydrolase; EC 3.6.5.5
Cellular Component: nucleoplasm; mitochondrial crista; mitochondrial outer membrane; membrane; mitochondrion; cytoplasm; mitochondrial inner membrane; dendrite; integral to membrane; mitochondrial intermembrane space
Molecular Function: GTPase activity; protein binding; GTP binding; hydrolase activity; nucleotide binding
Biological Process: inner mitochondrial membrane organization and biogenesis; positive regulation of neuron maturation; mitochondrion organization and biogenesis; mitochondrial genome maintenance; visual perception; mitochondrial fusion; apoptosis; response to stimulus; neural tube closure
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Diseases associated with OPA1 elisa kit
Organs/Tissues associated with OPA1 elisa kit
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