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ORAI1 peptide :: ORAI1 / CRACM1 Peptide

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Catalog # MBS426284
Unit / Price
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  0.1 mg  /  $190 +1 FREE 8GB USB
ORAI1 peptide
Product Name

ORAI1 / CRACM1, Peptide

Full Product Name

ORAI1 / CRACM1 Immunizing Peptide

Product Synonym Names
ORAI1; CRACM1; ORAI calcium release-activated calcium modulator 1; FLJ14466; ORAT1; TMEM142A; calcium release-activated calcium channel protein 1; calcium release-activated calcium modulator 1; transmembrane protein 142A; ORAI1 / CRACM1
Product Gene Name
Product Synonym Gene Name
Antibody/Peptide Pairs
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
Sequence
C-KKQPGQPR PTSKP
OMIM
610277
Species Reactivity
Human, Dog, Pig
Form/Format
100ug of dried peptide
Preparation and Storage
Shipped at ambient temperature, store at -20 degree C
ISO Certification
Manufactured in an ISO 9001:2015 Certified Laboratory.
Other Notes
Small volumes of ORAI1 peptide vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
NCBI/Uniprot data below describe general gene information for ORAI1. It may not necessarily be applicable to this product.
NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
25,337 Da
NCBI Official Full Name
calcium release-activated calcium channel protein 1
NCBI Official Synonym Full Names
ORAI calcium release-activated calcium modulator 1
NCBI Official Symbol
ORAI1  [Similar Products]
NCBI Official Synonym Symbols
IMD9; TAM2; ORAT1; CRACM1; TMEM142A
  [Similar Products]
NCBI Protein Information
calcium release-activated calcium channel protein 1
UniProt Protein Name
Calcium release-activated calcium channel protein 1
UniProt Synonym Protein Names
Protein orai-1; Transmembrane protein 142A
UniProt Gene Name
ORAI1  [Similar Products]
UniProt Synonym Gene Names
CRACM1; TMEM142A  [Similar Products]
UniProt Entry Name
CRCM1_HUMAN
NCBI Summary for ORAI1
The protein encoded by this gene is a membrane calcium channel subunit that is activated by the calcium sensor STIM1 when calcium stores are depleted. This type of channel is the primary way for calcium influx into T-cells. Defects in this gene are a cause of immune dysfunction with T-cell inactivation due to calcium entry defect type 1 (IDTICED1). [provided by RefSeq, Sep 2011]
UniProt Comments for ORAI1
ORAI1: Ca(2+) release-activated Ca(2+) (CRAC) channel subunit which mediates Ca(2+) influx following depletion of intracellular Ca(2+) stores and channel activation by the Ca(2+) sensor, STIM1. CRAC channels are the main pathway for Ca(2+) influx in T-cells and promote the immune response to pathogens by activating the transcription factor NFAT. Interacts with STIM1 and STIM2. Interacts with EFCAB4B/CRACR2A; the interaction is direct and takes place in absence of Ca(2+). Forms a complex with EFCAB4B/CRACR2A and STIM1 at low concentration of Ca(2+), the complex dissociates at elevated Ca(2+) concentrations. Belongs to the Orai family.

Protein type: Membrane protein, multi-pass; Channel, calcium; Membrane protein, integral

Chromosomal Location of Human Ortholog: 12q24.31

Cellular Component: autophagic vacuole; basolateral plasma membrane; cytoplasmic vesicle; integral to plasma membrane; membrane; protein complex

Molecular Function: calmodulin binding; identical protein binding; protein binding; store-operated calcium channel activity

Biological Process: adaptive immune response; positive regulation of calcium ion transport; regulation of calcium ion transport

Disease: Immunodeficiency 9; Myopathy, Tubular Aggregate, 2
Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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