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Otc recombinant protein :: Ornithine carbamoyltransferase Recombinant Protein

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Catalog # MBS960037
Unit / Price
  0.05 mg (E-Coli)  /  $730 +1 FREE 8GB USB
  0.05 mg (Yeast)  /  $850 +1 FREE 8GB USB
  0.2 mg (E-Coli)  /  $980 +1 FREE 8GB USB
  0.05 mg (Baculovirus)  /  $995 +1 FREE 8GB USB
  0.5 mg (E-Coli)  /  $1,075 +1 FREE 8GB USB
  0.2 mg (Yeast)  /  $1,145 +1 FREE 8GB USB
  0.05 mg (Mammalian-Cell)  /  $1,235 +1 FREE 8GB USB
  0.1 mg (Baculovirus)  /  $1,250 +1 FREE 8GB USB
  0.5 mg (Yeast)  /  $1,295 +1 FREE 8GB USB
  1 mg (E-Coli)  /  $1,525 +1 FREE 8GB USB
  0.5 mg (Baculovirus)  /  $1,805 +2 FREE 8GB USB
  0.1 mg (Mammalian-Cell)  /  $1,870 +2 FREE 8GB USB
  1 mg (Yeast)  /  $1,970 +2 FREE 8GB USB
  1 mg (Baculovirus)  /  $2,400 +3 FREE 8GB USB
SDS-Page
Product Name

Ornithine carbamoyltransferase (Otc), Recombinant Protein

Popular Item
Also Known As

Recombinant Mouse Ornithine carbamoyltransferase, mitochondrial

Product Synonym Names
Ornithine transcarbamylase; OTCase
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
MBS960037 COA
Sequence Positions
33-354aa; Full Length
Sequence Length
354
Sequence
SQVQLKGRDL LTLKNFTGEE IQYMLWLSAD LKFRIKQKGE YLPLLQGKSL GMIFEKRSTR TRLSTETGFA LLGGHPSFLT TQDIHLGVNE SLTDTARVLS SMTDAVLARV YKQSDLDTLA KEASIPIVNG LSDLYHPIQI LADYLTLQEH YGSLKGLTLS WIGDGNNILH SIMMSAAKFG MHLQAATPKG YEPDPNIVKL AEQYAKENGT KLSMTNDPLE AARGGNVLIT DTWISMGQED EKKKRLQAFQ GYQVTMKTAK VAASDWTFLH CLPRKPEEVD DEVFYSPRSL VFPEAENRKW TIMAVMVSLL TDYSPVLQKP KF
3D Structure
ModBase 3D Structure for P11725
Host
E Coli or Yeast or Baculovirus or Mammalian Cell
Purity/Purification
Greater than 90% as determined by SDS-PAGE. (lot specific)
Form/Format
Liquid containing glycerol
Tag Information
This protein contains an N-terminal tag and may also contain a C-terminal tag. Tag types are determined by various factors including tag-protein stability, please inquire for tag information.
Sterility
Sterile filter available upon request.
Endotoxin
Low endotoxin available upon request.
Preparation and Storage
Store at -20 degree C, for extended storage, conserve at -20 degree C or -80 degree C.
ISO Certification
Manufactured in an ISO 9001:2008 Certified Laboratory.
Other Notes
Small volumes of Otc recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Otc recombinant protein SDS-Page image
(Note: Representative image, actual molecular weight may vary depending on Tag type and expression host)
NCBI/Uniprot data below describe general gene information for Otc. It may not necessarily be applicable to this product.
NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
UniProt Primary Accession #
UniProt Related Accession #
Molecular Weight
52.1kD
NCBI Official Full Name
ornithine carbamoyltransferase, mitochondrial
NCBI Official Synonym Full Names
ornithine transcarbamylase
NCBI Official Symbol
NCBI Official Synonym Symbols
Sf; spf; AI265390
  [Similar Products]
NCBI Protein Information
ornithine carbamoyltransferase, mitochondrial
UniProt Protein Name
Ornithine carbamoyltransferase, mitochondrial
UniProt Synonym Protein Names
Ornithine transcarbamylase; OTCase
UniProt Gene Name
UniProt Synonym Gene Names
OTCase  [Similar Products]
UniProt Entry Name
OTC_MOUSE
UniProt Comments for Otc
OTC: Defects in OTC are the cause of ornithine carbamoyltransferase deficiency (OTCD). OTCD is an X- linked disorder of the urea cycle which causes a form of hyperammonemia. Mutations with no residual enzyme activity are always expressed in hemizygote males by a very severe neonatal hyperammonemic coma that generally proves to be fatal. Heterozygous females are either asymptomatic or express orotic aciduria spontaneously or after protein intake. The disorder is treatable with supplemental dietary arginine and low protein diet. The arbitrary classification of patients into the 'neonatal' group (clinical hyperammonemia in the first few days of life) and 'late' onset (clinical presentation after the neonatal period) has been used to differentiate severe from mild forms. Belongs to the ATCase/OTCase family.

Protein type: Mitochondrial; EC 2.1.3.3; Amino Acid Metabolism - arginine and proline; Transferase

Cellular Component: cytoplasm; mitochondrial inner membrane; mitochondrion

Molecular Function: amino acid binding; carboxyl- or carbamoyltransferase activity; ornithine carbamoyltransferase activity; phosphate binding; phospholipid binding; transferase activity

Biological Process: amino acid biosynthetic process; amino acid metabolic process; anion homeostasis; arginine biosynthetic process; arginine biosynthetic process via ornithine; citrulline biosynthetic process; ornithine catabolic process; ornithine metabolic process; urea cycle
Product References and Citations for Otc recombinant protein
The molecular basis of the sparse fur mouse mutation.Veres G., Gibbs R.A., Scherer S.E., Caskey C.T.Science 237:415-417(1987) The genetic structure of mouse ornithine transcarbamylase.Scherer S.E., Veres G., Caskey C.T.Nucleic Acids Res. 16:1593-1601(1988) The 5' flanking region of the ornithine transcarbamylase gene contains DNA sequences regulating tissue-specific expression.Veres G., Craigen W.J., Caskey C.T.J. Biol. Chem. 261:7588-7591(1986) SIRT5-mediated lysine desuccinylation impacts diverse metabolic pathways.Park J., Chen Y., Tishkoff D.X., Peng C., Tan M., Dai L., Xie Z., Zhang Y., Zwaans B.M., Skinner M.E., Lombard D.B., Zhao Y.Mol. Cell 50:919-930(2013) Label-free quantitative proteomics of the lysine acetylome in mitochondria identifies substrates of SIRT3 in metabolic pathways.Rardin M.J., Newman J.C., Held J.M., Cusack M.P., Sorensen D.J., Li B., Schilling B., Mooney S.D., Kahn C.R., Verdin E., Gibson B.W.Proc. Natl. Acad. Sci. U.S.A. 110:6601-6606(2013)

Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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