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P2Y12 elisa kit :: Rat Purinergic receptor P2Y, G-protein coupled, 12 ELISA Kit

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Catalog # MBS751174
Unit / Price
  48-Strip-Wells  /  $440 +1 FREE 8GB USB
  96-Strip-Wells  /  $640 +1 FREE 8GB USB
  5x96-Strip-Wells  /  $2,895 +3 FREE 8GB USB
  10x96-Strip-Wells  /  $5,415 +6 FREE 8GB USB
P2Y12 elisa kit
Product Name

Purinergic receptor P2Y, G-protein coupled, 12 (P2Y12), ELISA Kit

Also Known As

Rat Purinergic receptor P2Y, G-protein coupled, 12 ELISA Kit

Product Gene Name
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
Request for Current Manual Insert
OMIM
gene 609821
Species Reactivity
Samples
Serum, plasma, Cell Culture Supernatants, body fluid and tissue homogenate
Assay Type
Competitive
Detection Range
10-250ng/mL
Sensitivity
0.1ng/ml
Preparation and Storage
Store all reagents at 2-8 degree C.
Sample Preparation
We suggest pre-experimenting with neat (undiluted) samples, 1:2 or 1:4 dilutions. Please avoid diluting your samples more than 1:10 as it would exceed the dilution limit set for this kit. If the expected concentration of the target is beyond the detection range of the kit, please contact our technical support team
Product Note
Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual.
Other Notes
Small volumes of P2Y12 elisa kit vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Searchable Terms forP2Y12purchase
MBS751174 is a ready-to-use microwell, strip plate ELISA (enzyme-linked immunosorbent assay) Kit for analyzing the presence of the Purinergic receptor P2Y, G-protein coupled, 12 (P2Y12) ELISA Kit target analytes in biological samples. The concentration gradients of the kit standards or positive controls render a theoretical kit detection range in biological research samples containing P2Y12. The ELISA analytical biochemical technique of the MBS751174 kit is based on P2Y12 antibody-P2Y12 antigen interactions (immunosorbency) and an HRP colorimetric detection system to detect P2Y12 antigen targets in samples. The ELISA Kit is designed to detect native, not recombinant, P2Y12. Appropriate sample types may include undiluted body fluids and/or tissue homogenates, secretions. Quality control assays assessing reproducibility identified the intra-assay CV (%) and inter-assay CV(%).
NCBI/Uniprot data below describe general gene information for P2Y12. It may not necessarily be applicable to this product.
NCBI GI #
NCBI GeneID
NCBI Accession #
UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
39,439 Da
NCBI Official Full Name
Purinergic receptor P2Y, G-protein coupled, 12
NCBI Official Synonym Full Names
purinergic receptor P2Y, G-protein coupled, 12
NCBI Official Symbol
P2RY12  [Similar Products]
NCBI Official Synonym Symbols
HORK3; P2Y12; ADPG-R; BDPLT8; SP1999; P2T(AC); P2Y(AC); P2Y(12)R; P2Y(ADP); P2Y(cyc)
  [Similar Products]
NCBI Protein Information
P2Y purinoceptor 12; ADP-glucose receptor; purinergic receptor P2RY12; P2Y12 platelet ADP receptor; Gi-coupled ADP receptor HORK3; G-protein coupled receptor SP1999; putative G-protein coupled receptor
UniProt Protein Name
P2Y purinoceptor 12
UniProt Synonym Protein Names
ADP-glucose receptor; ADPG-R; P2T(AC); P2Y(AC); P2Y(cyc); P2Y12 platelet ADP receptor; P2Y(ADP); SP1999
UniProt Gene Name
P2RY12  [Similar Products]
UniProt Synonym Gene Names
HORK3; P2Y12; ADPG-R; P2Y(ADP)  [Similar Products]
UniProt Entry Name
P2Y12_HUMAN
NCBI Summary for P2Y12
The product of this gene belongs to the family of G-protein coupled receptors. This family has several receptor subtypes with different pharmacological selectivity, which overlaps in some cases, for various adenosine and uridine nucleotides. This receptor is involved in platelet aggregation, and is a potential target for the treatment of thromboembolisms and other clotting disorders. Mutations in this gene are implicated in bleeding disorder, platelet type 8 (BDPLT8). Alternative splicing results in multiple transcript variants of this gene. [provided by RefSeq, Jul 2013]
UniProt Comments for P2Y12
P2Y12: Receptor for ADP and ATP coupled to G-proteins that inhibit the adenylyl cyclase second messenger system. Not activated by UDP and UTP. Involved in platelets aggregation. Defects in P2RY12 are the cause of bleeding disorder platelet-type 8 (BDPLT8). A condition characterized by mild to moderate mucocutaneous bleeding, and excessive bleeding after surgery or trauma. The defect is due to severe impairment of platelet response to ADP resulting in defective platelet aggregation. Belongs to the G-protein coupled receptor 1 family.

Protein type: Membrane protein, multi-pass; GPCR, family 1; Receptor, GPCR; Mitochondrial; Membrane protein, integral

Chromosomal Location of Human Ortholog: 3q25.1

Cellular Component: cell surface; mitochondrion; integral to plasma membrane; basal plasma membrane; plasma membrane; intrinsic to membrane; caveola; external side of plasma membrane

Molecular Function: guanyl-nucleotide exchange factor activity; adenosine receptor activity, G-protein coupled; platelet ADP receptor activity

Biological Process: platelet activation; G-protein coupled receptor protein signaling pathway; negative regulation of cell differentiation; cell projection organization and biogenesis; hemostasis; protein kinase B signaling cascade; positive regulation of ion transport; G-protein signaling, adenylate cyclase inhibiting pathway; regulation of calcium ion transport; blood coagulation; adenosine receptor signaling pathway; positive regulation of GTPase activity

Disease: Bleeding Disorder, Platelet-type, 8
Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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