• Call +1.858.633.0165 or Fax +1.858.633.0166 or Contact Us

Pak1 recombinant protein :: Serine/threonine-protein kinase PAK 1 (Pak1) Recombinant Protein

Scan QR to view Datasheet
Catalog # MBS948667
Unit / Price
  0.05 mg (E-Coli)  /  $970 +1 FREE 8GB USB
  0.05 mg (Baculovirus)  /  $1,160 +1 FREE 8GB USB
  0.2 mg (E-Coli)  /  $1,295 +1 FREE 8GB USB
  0.2 mg (Yeast)  /  $1,400 +1 FREE 8GB USB
  0.05 mg (Mammalian-Cell)  /  $1,410 +1 FREE 8GB USB
  0.5 mg (E-Coli)  /  $1,430 +1 FREE 8GB USB
  0.1 mg (Baculovirus)  /  $1,475 +1 FREE 8GB USB
  0.5 mg (Yeast)  /  $1,585 +1 FREE 8GB USB
  1 mg (E-Coli)  /  $2,035 +2 FREE 8GB USB
  0.5 mg (Baculovirus)  /  $2,110 +2 FREE 8GB USB
  0.1 mg (Mammalian-Cell)  /  $2,125 +2 FREE 8GB USB
  1 mg (Yeast)  /  $2,410 +3 FREE 8GB USB
  1 mg (Baculovirus)  /  $2,770 +3 FREE 8GB USB
Pak1 recombinant protein
Product Name

Serine/threonine-protein kinase PAK 1 (Pak1), Recombinant Protein

Also Known As

Recombinant Rat Serine/threonine-protein kinase PAK 1 (Pak1)

Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
Sequence Positions
2-544aa, Full Length of Mature Protein
Sequence Length
544
Sequence
SNNGLDVQDK PPAPPMRNTS TMIGAGSKDP GTLNHGSKPL PPNPEEKKKK DRFYRSILAG DKTNKKKEKE RPEISLPSDF EHTIHVGFDA VTGEFTGMPE QWARLLQTSN ITKSEQKKNP QAVLDVLEFY NSKKTSNSQK YMSFTDKSAE DYNSSNTLNV KTVSETPAVP PVSEDEDDDD DATPPPVIAP RPEHTKSVYT RSVIEPLPVT PTRDVATSPI SPTENNTTPP DALTRNTEKQ KKKPKMSDEE ILEKLRSIVS VGDPKKKYTR FEKIGQGASG TVYTAMDVAT GQEVAIKQMN LQQQPKKELI INEILVMREN KNPNIVNYLD SYLVGDELWV VMEYLAGGSL TDVVTETCMD EGQIAAVCRE CLQALEFLHS NQVIHRDIKS DNILLGMDGS VKLTDFGFCA QITPEQSKRS TMVGTPYWMA PEVVTRKAYG PKVDIWSLGI MAIEMIEGEP PYLNENPLRA LYLIATNGTP ELQNPEKLSA IFRDFLNRCL EMDVEKRGSA KELLQHQFLK IAKPLSSLTP LIAAAKEATK NNH
3D Structure
ModBase 3D Structure for P35465
Host
E Coli or Yeast or Baculovirus or Mammalian Cell
Purity/Purification
>85% (SDS-PAGE) (lot specific)
Form/Format
Liquid containing glycerol
Tag Information
This protein contains an N-terminal tag and may also contain a C-terminal tag. Tag types are determined by various factors including tag-protein stability, please inquire for tag information.
Sterility
Sterile filter available upon request.
Endotoxin
Low endotoxin available upon request.
Species
Rat
Storage Buffer
Tris-based buffer, 50% glycerol
Tag Information
Tag type will be determined during the manufacturing process
Preparation and Storage
Store at -20 degrees C. For long-term storage, store at -20 degrees C or -80 degrees C. Store working aliquots at 4 degrees C for up to one week. Repeated freezing and thawing is not recommended.
ISO Certification
Manufactured in an ISO 9001:2008 Certified Laboratory.
Other Notes
Small volumes of Pak1 recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Related Product Information for
Pak1 recombinant protein
PAK proteins are critical effectors that link RhoGTPases to cytoskeleton reorganization and nuclear signaling. PAK proteins, a family of serine
threonine p21-activating kinases, include PAK1, PAK2, PAK3 and PAK4. These proteins serve as targets for the small GTP binding proteins Cdc42 and Rac and have been implicated in a wide range of biological activities. PAK1 regulates cell motility and morphology. Alternativelt spliced transcript variants encoding different isoforms have been found for this gene.
NCBI/Uniprot data below describe general gene information for Pak1. It may not necessarily be applicable to this product.
NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
UniProt Primary Accession #
UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
60,578 Da
NCBI Official Full Name
serine/threonine-protein kinase PAK 1
NCBI Official Synonym Full Names
p21 (RAC1) activated kinase 1
NCBI Official Symbol
NCBI Protein Information
serine/threonine-protein kinase PAK 1
UniProt Protein Name
Serine/threonine-protein kinase PAK 1
UniProt Synonym Protein Names
Alpha-PAK
UniProt Gene Name
UniProt Synonym Gene Names
PAK-1  [Similar Products]
NCBI Summary for Pak1
serine/threonine protein kinase; binds and forms complex specifically with activated (GTP-bound) p21, leading to inhibiting p21 GTPase activity [RGD, Feb 2006]
UniProt Comments for Pak1
Protein kinase involved in intracellular signaling pathways downstream of integrins and receptor-type kinases that plays an important role in cytoskeleton dynamics, in cell adhesion, migration, proliferation, apoptosis, mitosis, and in vesicle-mediated transport processes. Can directly phosphorylate BAD and protects cells against apoptosis. Activated by interaction with CDC42 and RAC1. Functions as GTPase effector that links the Rho-related GTPases CDC42 and RAC1 to the JNK MAP kinase pathway. Phosphorylates and activates MAP2K1, and thereby mediates activation of downstream MAP kinases. Involved in the reorganization of the actin cytoskeleton, actin stress fibers and of focal adhesion complexes. Phosphorylates the tubulin chaperone TBCB and thereby plays a role in the regulation of microtubule biogenesis and organization of the tubulin cytoskeleton. Plays a role in the regulation of insulin secretion in response to elevated glucose levels. Part of a ternary complex that contains PAK1, DVL1 and MUSK that is important for MUSK-dependent regulation of AChR clustering during the formation of the neuromuscular junction (NMJ). Activity is inhibited in cells undergoing apoptosis, potentially due to binding of CDC2L1 and CDC2L2. Phosphorylates MYL9/MLC2. Phosphorylates RAF1 at 'Ser-338' and 'Ser-339' resulting in: activation of RAF1, stimulation of RAF1 translocation to mitochondria, phosphorylation of BAD by RAF1, and RAF1 binding to BCL2. Phosphorylates SNAI1 at 'Ser-246' promoting its transcriptional repressor activity by increasing its accumulation in the nucleus. In podocytes, promotes NR3C2 nuclear localization. Required for atypical chemokine receptor ACKR2-induced phosphorylation of LIMK1 and cofilin (CFL1) and for the up-regulation of ACKR2 from endosomal compartment to cell membrane, increasing its efficiency in chemokine uptake and degradation. In synapses, seems to mediate the regulation of F-actin cluster formation performed by SHANK3, maybe through CFL1 phosphorylation and inactivation. Plays a role in RUFY3-mediated facilitating gastric cancer cells migration and invasion.
Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
Request a Quote

Please fill out the form below and our representative will get back to you shortly.

MBS000000
Contact Us

Please fill out the form below and our representative will get back to you shortly.

MBS000000