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anti-PAK7 antibody :: PAK7 Antibody

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Catalog # MBS855963
Unit / Price
  0.1 mg  /  $215 +1 FREE 8GB USB
Testing Data #3
Product Name

PAK7, Antibody

Popular Item
Also Known As

PAK7 Antibody

Product Synonym Names
KIAA1264; p21-activated kinase 7; PAK 7; PAK-5; PAK-7; PAK5; PAK7
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
Immunogen Sequence Length
719
OMIM
608038
3D Structure
ModBase 3D Structure for Q9P286
Species Reactivity
Human, Mouse, Rat
Specificity
PAK7 antibody detects endogenous levels of total PAK7 protein.
Purity/Purification
Affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Form/Format
In phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Immunogen
The antiserum was produced against synthesized peptide derived from C-terminal of human PAK7.
Preparation and Storage
Store at-20 degree C for 1 year.
Other Notes
Small volumes of anti-PAK7 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Applications Tested/Suitable for anti-PAK7 antibody
Western Blot (WB), Immunohistochemistry (IHC), ELISA (EIA)
Application Notes for anti-PAK7 antibody
WB: 1:500~1:1000
IHC: 1:50~1:100
ELISA: 1:40000

Testing Data #3 of anti-PAK7 antibody
Immunohistochemistry analysis of paraffin-embedded human brain tissue, using PAK7 antibody.
Western blot analysis of extracts from rat brain cells, using PAK7 antibody.
anti-PAK7 antibody Testing Data #3 image
NCBI/Uniprot data below describe general gene information for PAK7. It may not necessarily be applicable to this product.
NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
UniProt Primary Accession #
UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
80,745 Da
NCBI Official Full Name
serine/threonine-protein kinase PAK 5
NCBI Official Synonym Full Names
p21 (RAC1) activated kinase 5
NCBI Official Symbol
NCBI Official Synonym Symbols
NCBI Protein Information
serine/threonine-protein kinase PAK 5
UniProt Protein Name
Serine/threonine-protein kinase PAK 5
UniProt Synonym Protein Names
p21-activated kinase 5; PAK-5; p21-activated kinase 7; PAK-7
UniProt Gene Name
UniProt Synonym Gene Names
PAK-5; PAK-7  [Similar Products]
NCBI Summary for PAK7
The protein encoded by this gene is a member of the PAK family of Ser/Thr protein kinases. PAK family members are known to be effectors of Rac/Cdc42 GTPases, which have been implicated in the regulation of cytoskeletal dynamics, proliferation, and cell survival signaling. This kinase contains a CDC42/Rac1 interactive binding (CRIB) motif, and has been shown to bind CDC42 in the presence of GTP. This kinase is predominantly expressed in brain. It is capable of promoting neurite outgrowth, and thus may play a role in neurite development. This kinase is associated with microtubule networks and induces microtubule stabilization. The subcellular localization of this kinase is tightly regulated during cell cycle progression. Alternatively spliced transcript variants encoding the same protein have been described. [provided by RefSeq, Jul 2008]
UniProt Comments for PAK7
Serine/threonine protein kinase that plays a role in a variety of different signaling pathways including cytoskeleton regulation, cell migration, proliferation or cell survival. Activation by various effectors including growth factor receptors or active CDC42 and RAC1 results in a conformational change and a subsequent autophosphorylation on several serine and/or threonine residues. Phosphorylates the proto-oncogene RAF1 and stimulates its kinase activity. Promotes cell survival by phosphorylating the BCL2 antagonist of cell death BAD. Phosphorylates CTNND1, probably to regulate cytoskeletal organization and cell morphology. Keeps microtubules stable through MARK2 inhibition and destabilizes the F-actin network leading to the disappearance of stress fibers and focal adhesions.
Product References and Citations for anti-PAK7 antibody
Pandey A., Oncogene 21:3939-3948(2002). Nagase T., DNA Res. 6:337-345(1999). Deloukas P., Nature 414:865-871(2001).

Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

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