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PAP native protein

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Catalog # MBS537789
Unit / Price
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  1 mg  /  $180 +1 FREE 8GB USB
PAP native protein
Product Name

PAP, Native Protein

Full Product Name

PAP protein (> 40% pure)

Product Synonym Names
PAP protein; PAP antigen; Prostatic Acid Phosphatase protein
Matching Pairs
Antibody: PAP Clone #M01010922 (MBS530241)
Antigen: PAP (MBS537789)
Comments: Prepared from human seminal fluid. >40% pure by SDS-PAGE
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
OMIM
171790
3D Structure
ModBase 3D Structure for P15309
Host
Human
Purity/Purification
> 40% pure
Form/Format
Supplied 0.2 micron filtered in 150mM NaCl, 9.5mM Sodium Phosphate Monobasic, 40.5mM Sodium Phosphate Dibasic, pH 7.6 with 0.05% NaN3
Source Note
Human seminal fluid
Protein Type
Native
Biological Significance
Prostatic acid phosphatase (PAP), also prostatic specific acid phosphatase (PSAP), is an enzyme produced by the prostate. It may be found in increased amounts in men who have prostate cancer or other diseases. The highest levels of acid phosphatase are found in metastasized prostate cancer.
Biohazard Information
Donor samples were tested and found to be negative for  HIV I/II, and HCV antibodies, and Hepatitis B surface antigen. Nonetheless caution should be used when handling this material as there is a margin of error in all tests. This product contains sodium azide as preservative. Although the amount of sodium azide is very small appropriate care must be taken when handling this product.
Dry Ice Shipment
Extra charge fee may add to your shipping cost as dry ice is required to ship this product.
Preparation and Storage
Aliquot and store at -20 degree C. Avoid repeated Freeze/Thaw cycles.
Other Notes
Small volumes of PAP native protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Related Product Information for
PAP native protein
Purified native Human PAP protein (> 40% pure)
Product Categories/Family for PAP native protein
Applications Tested/Suitable for PAP native protein
User optimized
NCBI/Uniprot data below describe general gene information for PAP. It may not necessarily be applicable to this product.
NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
UniProt Primary Accession #
UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
51 kDa
NCBI Official Full Name
prostatic acid phosphatase isoform PAP
NCBI Official Synonym Full Names
acid phosphatase, prostate
NCBI Official Symbol
NCBI Official Synonym Symbols
ACP3; 5'-NT; ACP-3
  [Similar Products]
NCBI Protein Information
prostatic acid phosphatase
UniProt Protein Name
Prostatic acid phosphatase
UniProt Synonym Protein Names
5'-nucleotidase (EC:3.1.3.5); 5'-NT
Protein Family
UniProt Gene Name
UniProt Synonym Gene Names
PAP; 5'-NT; TMPase  [Similar Products]
UniProt Entry Name
PPAP_HUMAN
NCBI Summary for PAP
This gene encodes an enzyme that catalyzes the conversion of orthophosphoric monoester to alcohol and orthophosphate. It is synthesized under androgen regulation and is secreted by the epithelial cells of the prostate gland. An alternatively spliced transcript variant encoding a longer isoform has been found for this gene. This isoform contains a transmembrane domain and is localized in the plasma membrane-endosomal-lysosomal pathway. [provided by RefSeq, Sep 2008]
UniProt Comments for PAP
ACPP: A non-specific tyrosine phosphatase that dephosphorylates a diverse number of substrates under acidic conditions (pH 4-6) including alkyl, aryl, and acyl orthophosphate monoesters and phosphorylated proteins. Has lipid phosphatase activity and inactivates lysophosphatidic acid in seminal plasma. Belongs to the histidine acid phosphatase family. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: EC 3.1.3.2; Phosphatase; Cofactor and Vitamin Metabolism - riboflavin; EC 3.1.3.5; Motility/polarity/chemotaxis

Chromosomal Location of Human Ortholog: 3q22.1

Cellular Component: multivesicular body; extracellular space; Golgi cisterna; apical part of cell; lysosomal membrane; integral to membrane; plasma membrane; intracellular; vesicle membrane; nucleus; secretory granule; filopodium

Molecular Function: 5'-nucleotidase activity; choline binding; identical protein binding; acid phosphatase activity; protein homodimerization activity; phosphoric monoester hydrolase activity; thiamin phosphate phosphatase activity

Biological Process: thiamin metabolic process; dephosphorylation; positive regulation of adenosine receptor signaling pathway; nucleotide metabolic process; regulation of sensory perception of pain; adenosine metabolic process; purine base metabolic process
Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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