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PAPSS1 recombinant protein :: PAPS Synthase 1/PAPSS1 Recombinant Protein

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Catalog # MBS2553050
Unit / Price
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  0.01 mg  /  $235 +1 FREE 8GB USB
  0.05 mg  /  $580 +1 FREE 8GB USB
PAPSS1 recombinant protein
Product Name

PAPS Synthase 1/PAPSS1, Recombinant Protein

Full Product Name

Recombinant Human PAPS Synthase 1/PAPSS1 Protein (C-6His)

Product Synonym Names
Bifunctional 3'-phosphoadenosine 5'-phosphosulfate synthase 1; PAPS synthase 1; PAPSS 1; Sulfurylase kinase 1; SK 1; ATPSK1; PAPSS
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
Sequence Positions
Met1-Ala624
3D Structure
ModBase 3D Structure for Q96A00
Host
Human Cells
Purity/Purification
>95% as determined by reducing SDS-PAGE.
Form/Format
Supplied as a 0.2 mum filtered solution of 20mM Tris, 100mM NaCl, 20% Glycerol, pH 8.0.
Species
Human
Endotoxin
<1.0 EU per ug as determined by LAL test.
Fusion Tag
C-6His
Preparation and Storage
Store at < -20 degree C, stable for 6 months after receipt. Please minimize freeze-thaw cycles.
ISO Certification
Manufactured in an ISO 9001:2008 Certified Laboratory.
Other Notes
Small volumes of PAPSS1 recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Related Product Information for
PAPSS1 recombinant protein
PAPSS1 is a bifunctional enzyme with both ATP sulfurylase and APS kinase activity. In the N-terminal section, it belongs to the APS kinase family; while the C-terminal section belongs to the sulfate adenylyltransferase family. PAPSS1 can be inhibited by chlorate, and is expressed in many tissues, such as high endothelial venules (HEV) cells and in cartilage. PAPSS1 mediates two steps in the sulfate activation pathway. The first step is the transfer of a sulfate group to ATP to yield adenosine 5'-phosphosulfate (APS), and the second step is the transfer of a phosphate group from ATP to APS yielding 3'-phosphoadenylylsulfate. In mammals, PAPS is the sole source of sulfate; APS appears to be only an intermediate in the sulfate-activation pathway. PAPSS1 also involved in the biosynthesis of sulfated L-selectin ligands in endothelial cells.
NCBI/Uniprot data below describe general gene information for PAPSS1. It may not necessarily be applicable to this product.
NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
UniProt Primary Accession #
UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
Molecular Mass: 71.9 kDa
Actual Protein Molecular Mass: 22 kDa
NCBI Official Full Name
protein phosphatase 1 regulatory subunit 14A isoform 2
NCBI Official Synonym Full Names
protein phosphatase 1 regulatory inhibitor subunit 14A
NCBI Official Symbol
PPP1R14A  [Similar Products]
NCBI Official Synonym Symbols
CPI17; CPI-17; PPP1INL
  [Similar Products]
NCBI Protein Information
protein phosphatase 1 regulatory subunit 14A
UniProt Protein Name
Protein phosphatase 1 regulatory subunit 14A
UniProt Synonym Protein Names
17 kDa PKC-potentiated inhibitory protein of PP1; Protein kinase C-potentiated inhibitor protein of 17 kDa; CPI-17
UniProt Gene Name
PPP1R14A  [Similar Products]
UniProt Synonym Gene Names
CPI17; PPP1INL; CPI-17  [Similar Products]
NCBI Summary for PAPSS1
The protein encoded by this gene belongs to the protein phosphatase 1 (PP1) inhibitor family. This protein is an inhibitor of smooth muscle myosin phosphatase, and has higher inhibitory activity when phosphorylated. Inhibition of myosin phosphatase leads to increased myosin phosphorylation and enhanced smooth muscle contraction. Alternatively spliced transcript variants encoding different isoforms have been noted for this gene. [provided by RefSeq, Sep 2011]
UniProt Comments for PAPSS1
Inhibitor of PPP1CA. Has over 1000-fold higher inhibitory activity when phosphorylated, creating a molecular switch for regulating the phosphorylation status of PPP1CA substrates and smooth muscle contraction.
Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
Products associated withPAPSS1 recombinant protein
 Reference Product  PubMed Publications
 PRKCA recombinant protein  >2 publications with PAPSS1 and PRKCA
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