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PARK7 recombinant protein :: Parkinson Disease Protein 7 Recombinant Protein

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Catalog # MBS143125
Unit / Price
  0.005 mg  /  $140 +1 FREE 8GB USB
  0.02 mg  /  $205 +1 FREE 8GB USB
  1 mg  /  $2,940 +3 FREE 8GB USB
PARK7 recombinant protein
Product Name

Parkinson Disease Protein 7 (PARK7), Recombinant Protein

Popular Item
Also Known As

Recombinant Human Parkinson Disease Protein 7

Product Synonym Names
Protein DJ-1, Oncogene DJ1, Parkinson disease protein 7, PARK7, DJ1, DJ-1, FLJ27376.
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
Sequence Length
189
Sequence
MRGSHHH HHH GMASMTGGQQ MGRDLYDDDD KDRWGS MASK RALVILAKGA EEMETVIPVD VMRRAGIKVT VAGLAGKDPV QCSRDVVICP DASLEDAKKE GPYDVVVLPG GNLGAQNLSE SAAVKEILKE QENRKGLIAA ICAGPTALLA HEIGFGSKVT THPLAKDKMM NGGHYTYSEN RVEKDGLILT SRGPGTSFEF ALAIVEALNG KEVAAQVKAP LVLKD
OMIM
168600
3D Structure
ModBase 3D Structure for Q99497
Host
E Coli
Purity/Purification
Greater than 95.0% as determined by SDS-PAGE.
Form/Format
The protein solution (1mg/ml) contains 20mM Tris-HCl pH-8 and 20% glycerol.
Sterile Filtered colorless solution.
Concentration
1mg/ml (lot specific)
Preparation and Storage
Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time.
For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).
Avoid multiple freeze-thaw cycles
Other Notes
Small volumes of PARK7 recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Related Product Information for
PARK7 recombinant protein
Description: PARK7 Human Recombinant fused to an N-terminal 36 aa His-Tag, produced in E Coli is a single, non-glycosylated polypeptide chain (aa 1-189) containing 225 amino acids and having a molecular mass of 24 kDa.

Introduction: The PARK7 is a ubiquitously expressed protein involved in various cellular processes including spermatogenesis and fertilization, cancer, RNA-binding, androgen-receptor signaling and oxidative stress. Mutations in the PARK7 are the cause of autosomal recessive early-onset Parkinson's disease 7 (Park7).
NCBI/Uniprot data below describe general gene information for PARK7. It may not necessarily be applicable to this product.
NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
UniProt Primary Accession #
UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
19,891 Da
NCBI Official Full Name
protein DJ-1
NCBI Official Synonym Full Names
parkinson protein 7
NCBI Official Symbol
PARK7  [Similar Products]
NCBI Official Synonym Symbols
DJ1; DJ-1; HEL-S-67p
  [Similar Products]
NCBI Protein Information
protein DJ-1; Parkinson disease (autosomal recessive, early onset) 7; epididymis secretory sperm binding protein Li 67p; oncogene DJ1
UniProt Protein Name
Protein DJ-1
UniProt Synonym Protein Names
Oncogene DJ1; Parkinson disease protein 7
Protein Family
UniProt Gene Name
PARK7  [Similar Products]
UniProt Entry Name
PARK7_HUMAN
NCBI Summary for PARK7
The product of this gene belongs to the peptidase C56 family of proteins. It acts as a positive regulator of androgen receptor-dependent transcription. It may also function as a redox-sensitive chaperone, as a sensor for oxidative stress, and it apparently protects neurons against oxidative stress and cell death. Defects in this gene are the cause of autosomal recessive early-onset Parkinson disease 7. Two transcript variants encoding the same protein have been identified for this gene. [provided by RefSeq, Jul 2008]
UniProt Comments for PARK7
DJ-1: associated with autosomal recessive early onset parkinsonism. Involved in the oxidative stress response. Three cysteines in DJ-1 may be oxidized to cysteine sulphonic acid in the cellular response to H2O2. Loss of DJ-1 function may lead to neurodegeneration.

Protein type: Transcription regulation; Tumor suppressor; EC 3.4.-.-; Nuclear receptor co-regulator

Chromosomal Location of Human Ortholog: 1p36.23

Cellular Component: PML body; mitochondrion; mitochondrial matrix; axon; cytoplasm; plasma membrane; mitochondrial intermembrane space; mitochondrial respiratory chain complex I; chromatin; nucleus; cytosol; lipid raft

Molecular Function: identical protein binding; oxidoreductase activity, acting on peroxide as acceptor; protein homodimerization activity; transcription coactivator activity; mercury ion binding; transcription factor binding; mRNA binding; peptidase activity; protein binding; enzyme binding; copper ion binding; peroxiredoxin activity; androgen receptor binding; cytokine binding; double-stranded DNA binding; glyoxalase III activity; superoxide dismutase copper chaperone activity; kinase binding; single-stranded DNA binding; receptor binding

Biological Process: negative regulation of protein export from nucleus; adult locomotory behavior; protein deglycosylation; membrane hyperpolarization; proteolysis; glycolate biosynthetic process; positive regulation of interleukin-8 production; negative regulation of protein amino acid phosphorylation; regulation of mitochondrial membrane potential; single fertilization; regulation of neuron apoptosis; enzyme active site formation via L-cysteine sulfinic acid; dopamine uptake; negative regulation of neuron apoptosis; negative regulation of protein binding; inflammatory response; mitochondrion organization and biogenesis; protein stabilization; activation of protein kinase B; regulation of TRAIL receptor biosynthetic process; detoxification of copper ion; negative regulation of proteasomal ubiquitin-dependent protein catabolic process; negative regulation of protein sumoylation; positive regulation of peptidyl-serine phosphorylation; methylglyoxal catabolic process to D-lactate; positive regulation of protein kinase B signaling cascade; membrane depolarization; detoxification of mercury ion; regulation of inflammatory response; Ras protein signal transduction; negative regulation of ubiquitin-protein ligase activity; hydrogen peroxide metabolic process; negative regulation of protein kinase activity; autophagy; lactate biosynthetic process; positive regulation of transcription factor activity; positive regulation of transcription from RNA polymerase II promoter; negative regulation of protein ubiquitination; negative regulation of apoptosis

Disease: Parkinson Disease 7, Autosomal Recessive Early-onset
Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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