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PAX6 peptide

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Catalog # MBS425195
Unit / Price
  0.1 mg  /  $190 +1 FREE 8GB USB
PAX6 peptide
Product Name

PAX6, Peptide

Also Known As

PAX6 Immunizing Peptide

Product Synonym Names
PAX6; paired box gene 6 (aniridia, keratitis); AN; AN2; D11S812E; MGC17209; MGDA; WAGR; paired box gene 6; paired box homeotic gene 6 (aniridia, keratitis); paired box homeotic gene-6; PAX6 (internal)
Product Gene Name
Antibody/Peptide Pairs
PAX6 peptide (MBS425195) is used for blocking the activity of PAX6 antibody (MBS421087)
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
Sequence Length
Species Reactivity
Human, Mouse, Rat
100ug of dried peptide
Preparation and Storage
Shipped at ambient temperature, store at -20 degree C
ISO Certification
Manufactured in an ISO 9001:2015 Certified Laboratory.
Other Notes
Small volumes of PAX6 peptide vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
NCBI/Uniprot data below describe general gene information for PAX6. It may not necessarily be applicable to this product.
NCBI Accession #
NCBI Related Accession #
Manufactured in an ISO 9001:2015 Certified Laboratory.NP_001595.2[Other Products]
NCBI GenBank Nucleotide #
UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
– Da
NCBI Official Full Name
paired box protein Pax-6 isoform a
NCBI Official Synonym Full Names
paired box 6
NCBI Official Symbol
NCBI Official Synonym Symbols
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NCBI Protein Information
paired box protein Pax-6
UniProt Protein Name
Paired box protein Pax-6
UniProt Synonym Protein Names
Aniridia type II protein; Oculorhombin
Protein Family
UniProt Gene Name
UniProt Synonym Gene Names
UniProt Entry Name
NCBI Summary for PAX6
This gene encodes a homeobox and paired domain-containing protein that binds DNA and functions as a regulator of transcription. Activity of this protein is key in the development of neural tissues, particularly the eye. This gene is regulated by multiple enhancers located up to hundreds of kilobases distant from this locus. Mutations in this gene or in the enhancer regions can cause ocular disorders such as aniridia and Peter's anomaly. Use of alternate promoters and alternative splicing result in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2015]
UniProt Comments for PAX6
PAX6: Transcription factor with important functions in the development of the eye, nose, central nervous system and pancreas. Required for the differentiation of pancreatic islet alpha cells. Competes with PAX4 in binding to a common element in the glucagon, insulin and somatostatin promoters. Regulates specification of the ventral neuron subtypes by establishing the correct progenitor domains. Isoform 5a appears to function as a molecular switch that specifies target genes. Defects in PAX6 are the cause of aniridia (AN). A congenital, bilateral, panocular disorder characterized by complete absence of the iris or extreme iris hypoplasia. Aniridia is not just an isolated defect in iris development but it is associated with macular and optic nerve hypoplasia, cataract, corneal changes, nystagmus. Visual acuity is generally low but is unrelated to the degree of iris hypoplasia. Glaucoma is a secondary problem causing additional visual loss over time. Defects in PAX6 are a cause of Peters anomaly (PAN). Peters anomaly consists of a central corneal leukoma, absence of the posterior corneal stroma and Descemet membrane, and a variable degree of iris and lenticular attachments to the central aspect of the posterior cornea. Defects in PAX6 are a cause of foveal hypoplasia (FOVHYP). Foveal hypoplasia can be isolated or associated with presenile cataract. Inheritance is autosomal dominant. Defects in PAX6 are a cause of keratitis hereditary (KERH). An ocular disorder characterized by corneal opacification, recurrent stromal keratitis and vascularization. Defects in PAX6 are a cause of coloboma of iris choroid and retina (COI); also known as uveoretinal coloboma. Ocular colobomas are a set of malformations resulting from abnormal morphogenesis of the optic cup and stalk, and the fusion of the fetal fissure (optic fissure). Severe colobomatous malformations may cause as much as 10% of the childhood blindness. The clinical presentation of ocular coloboma is variable. Some individuals may present with minimal defects in the anterior iris leaf without other ocular defects. More complex malformations create a combination of iris, uveoretinal and/or optic nerve defects without or with microphthalmia or even anophthalmia. Defects in PAX6 are a cause of coloboma of optic nerve (COLON). Defects in PAX6 are a cause of bilateral optic nerve hypoplasia (BONH); also known as bilateral optic nerve aplasia. A congenital anomaly in which the optic disc appears abnormally small. It may be an isolated finding or part of a spectrum of anatomic and functional abnormalities that includes partial or complete agenesis of the septum pellucidum, other midline brain defects, cerebral anomalies, pituitary dysfunction, and structural abnormalities of the pituitary. Defects in PAX6 are a cause of aniridia cerebellar ataxia and mental deficiency (ACAMD); also known as Gillespie syndrome. A rare condition consisting of partial rudimentary iris, cerebellar impairment of the ability to perform coordinated voluntary movements, and mental retardation. Belongs to the paired homeobox family. 3 isoforms of the human protein are produced by alternative splicing.

Protein type: Transcription factor; DNA-binding; Motility/polarity/chemotaxis

Chromosomal Location of Human Ortholog: 11p13

Cellular Component: cytoplasm; nuclear chromatin; nucleoplasm; nucleus

Molecular Function: chromatin binding; DNA binding; histone acetyltransferase binding; protein binding; protein kinase binding; transcription factor activity; transcription factor binding; ubiquitin protein ligase binding; ubiquitin-protein ligase activity

Biological Process: astrocyte differentiation; axon guidance; blood vessel development; cell fate determination; central nervous system development; cerebral cortex regionalization; commitment of a neuronal cell to a specific type of neuron in the forebrain; dorsal/ventral axis specification; embryonic camera-type eye morphogenesis; establishment of mitotic spindle orientation; eye development; eye photoreceptor cell development; forebrain anterior/posterior pattern formation; forebrain dorsal/ventral pattern formation; forebrain-midbrain boundary formation; glucose homeostasis; keratinocyte differentiation; lacrimal gland development; lens development in camera-type eye; negative regulation of epithelial cell proliferation; negative regulation of neurogenesis; negative regulation of neuron differentiation; negative regulation of protein amino acid phosphorylation; negative regulation of transcription from RNA polymerase II promoter; neuron fate commitment; neuron migration; oligodendrocyte cell fate specification; organ morphogenesis; pituitary gland development; positive regulation of epithelial cell differentiation; positive regulation of neuroblast proliferation; positive regulation of transcription from RNA polymerase II promoter; positive regulation of transcription, DNA-dependent; protein localization in organelle; protein ubiquitination; regulation of asymmetric cell division; regulation of cell migration; regulation of timing of cell differentiation; regulation of transcription from RNA polymerase II promoter involved in somatic motor neuron fate commitment; regulation of transcription from RNA polymerase II promoter involved in spinal cord motor neuron fate specification; regulation of transcription from RNA polymerase II promoter involved in ventral spinal cord interneuron specification; response to wounding; retina development in camera-type eye; salivary gland morphogenesis; smoothened signaling pathway; transcription from RNA polymerase II promoter; visual perception

Disease: Aniridia; Aniridia, Cerebellar Ataxia, And Mental Retardation; Coloboma Of Optic Nerve; Foveal Hypoplasia 1; Keratitis, Hereditary; Optic Nerve Hypoplasia, Bilateral; Peters Anomaly; Wilms Tumor, Aniridia, Genitourinary Anomalies, And Mental Retardation Syndrome
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While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

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