NP_001269921.1
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NCBI GenBank Nucleotide #
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UniProt Primary Accession #
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UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
329,465 Da
NCBI Official Full Name
pericentrin isoform b
NCBI Official Synonym Full Names
pericentrin (kendrin)
NCBI Official Synonym Symbols
KEN; Pcnt2; C86676; kendrin; m239Asp; m275Asp; AW476095 [Similar Products]
NCBI Protein Information
pericentrin; pericentrin 2; pericentrin-250; pericentrin-360
UniProt Protein Name
Pericentrin
UniProt Synonym Gene Names
UniProt Entry Name
PCNT_MOUSE
UniProt Comments for PCNT
PCNT: Integral component of the filamentous matrix of the centrosome involved in the initial establishment of organized microtubule arrays in both mitosis and meiosis. Plays a role, together with DISC1, in the microtubule network formation. Is an integral component of the pericentriolar material (PCM). May play an important role in preventing premature centrosome splitting during interphase by inhibiting NEK2 kinase activity at the centrosome. Defects in PCNT are the cause of microcephalic osteodysplastic primordial dwarfism type 2 (MOPD2); also known as osteodysplastic primordial dwarfism type 2. Adults with this rare inherited condition have an average height of 100 centimeters and a brain size comparable to that of a 3-month-old baby, but are of near-normal intelligence. 2 isoforms of the human protein are produced by alternative splicing.
Protein type: Cell cycle regulation
Cellular Component: centriole; centrosome; microtubule; pericentriolar material; intercellular bridge; cytoskeleton; cytoplasm; microtubule organizing center
Molecular Function: calmodulin binding; protein binding
Biological Process: cerebellar cortex morphogenesis; in utero embryonic development; olfactory bulb development; multicellular organism growth; neuron migration; brain morphogenesis; cilium biogenesis; limb morphogenesis; spindle organization and biogenesis; negative regulation of apoptosis
Research Articles on PCNT
Precautions
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Pathways associated with PCNT elisa kit
Diseases associated with PCNT elisa kit
Organs/Tissues associated with PCNT elisa kit
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