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PCSK9 recombinant protein :: (Rhesus macaque) Proprotein convertase subtilisin/kexin type 9 (PCSK9) Recombinant Protein

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Catalog # MBS1073542
Unit / Price
  1 mg (E-Coli)  /  $2,155 +2 FREE 8GB USB
  1 mg (Yeast)  /  $2,615 +3 FREE 8GB USB
PCSK9 recombinant protein
Product Name

(Rhesus macaque) Proprotein convertase subtilisin/kexin type 9 (PCSK9), Recombinant Protein

Also Known As

Recombinant Macaca mulatta (Rhesus macaque) Proprotein convertase subtilisin/kexin type 9 (PCSK9)

Product Synonym Names
Recombinant (Rhesus macaque) Proprotein convertase subtilisin/kexin type 9 (PCSK9); Proprotein convertase subtilisin/kexin type 9 EC= 3.4.21.-; Proprotein convertase 9; PC9 Subtilisin/kexin-like protease PC9
Product Synonym Gene Name
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
Sequence Positions
153-692
Sequence Length
692
Sequence
SIPWNLERIT PARYRADEYQ PPKGGSLVEV YLLDTSIQSD HREIEGRVMV TDFESVPEED GTRFHRQASK CDSHGTHLAG VVSGRDAGVA KGAGLRSLRV LNCQGKGTVS GTLIGLEFIR KSQLVQPVGP LVVLLPLAGG YSRVFNAACQ RLARAGVVLV TAAGNFRDDA CLYSPASAPE VITVGATNAQ DQPVTLGTLG TNFGRCVDLF APGEDIIGAS SDCSTCFVSR SGTSQAAAHV AGIAAMMLSA EPELTLAELR QRLIHFSAKD VINEAWFPED QRVLTPNLVA ALPPSTHRAG WQLFCRTVWS AHSGPTRMAT AVARCAQDEE LLSCSSFSRS GKRRGERIEA QGGKRVCRAH NAFGGEGVYA IARCCLLPQV NCSVHTAPPA GASMGTRVHC HQQGHVLTGC SSHWEVEDLG THKPPVLRPR GQPNQCVGHR EASIHASCCH APGLECKVKE HGIPAPQEQV IVACEDGWTL TGCSPLPGTS HVLGAYAVDN TCVVRSRDVS TTGSTSKEAV AAVAICCRSR HLVQASQELQ
Chromosome Location
chromosome: 1
3D Structure
ModBase 3D Structure for A8T666
Host
E Coli or Yeast or Baculovirus or Mammalian Cell
Purity/Purification
>=90% (lot specific)
Form/Format
Liquid containing glycerol
Tag Information
This protein contains an N-terminal tag and may also contain a C-terminal tag. Tag types are determined by various factors including tag-protein stability, please inquire for tag information.
Sterility
Sterile filter available upon request.
Endotoxin
Low endotoxin available upon request.
Species
Macaca mulatta (Rhesus macaque)
Preparation and Storage
Store at -20 degree C. For extended storage, store at -20 or -80 degree C.
ISO Certification
Manufactured in an ISO 9001:2008 Certified Laboratory.
Other Notes
Small volumes of PCSK9 recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
NCBI/Uniprot data below describe general gene information for PCSK9. It may not necessarily be applicable to this product.
NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
UniProt Primary Accession #
UniProt Related Accession #
Molecular Weight
74,528 Da[Similar Products]
NCBI Official Full Name
proprotein convertase subtilisin/kexin type 9
NCBI Official Symbol
PCSK9  [Similar Products]
NCBI Official Synonym Symbols
NCBI Protein Information
proprotein convertase subtilisin/kexin type 9; proprotein convertase 9; proprotein convertase PC9; subtilisin/kexin-like protease PC9; proprotein convertase subtilisin/kexin type 9 preproprotein
UniProt Protein Name
Proprotein convertase subtilisin/kexin type 9
UniProt Synonym Protein Names
Proprotein convertase 9; PC9; Subtilisin/kexin-like protease PC9
UniProt Gene Name
PCSK9  [Similar Products]
UniProt Synonym Gene Names
UniProt Entry Name
PCSK9_MACMU
UniProt Comments for PCSK9
Function: Crucial player in the regulation of plasma cholesterol homeostasis. Binds to low-density lipid receptor family members: low density lipoprotein receptor (LDLR), very low density lipoprotein receptor (VLDLR), apolipoprotein E receptor (LRP1/APOER) and apolipoprotein receptor 2 (LRP8/APOER2), and promotes their degradation in intracellular acidic compartments. Acts via a non-proteolytic mechanism to enhance the degradation of the hepatic LDLR through a clathrin LDLRAP1/ARH-mediated pathway. May prevent the recycling of LDLR from endosomes to the cell surface or direct it to lysosomes for degradation. Can induce ubiquitination of LDLR leading to its subsequent degradation. Inhibits intracellular degradation of APOB via the autophagosome/lysosome pathway in a LDLR-independent manner. Involved in the disposal of non-acetylated intermediates of BACE1 in the early secretory pathway. Inhibits epithelial Na+ channel (ENaC)-mediated Na+ absorption by reducing ENaC surface expression primarily by increasing its proteasomal degradation. Regulates neuronal apoptosis via modulation of LRP8/APOER2 levels and related anti-apoptotic signaling pathways

By similarity.

Cofactor: Calcium

By similarity.

Enzyme regulation: Its proteolytic activity is autoinhibited by the non-covalent binding of the propeptide to the catalytic domain. Inhibited by EGTA

By similarity.

Subunit structure: Monomer. Can self-associate to form dimers and higher multimers which may have increased LDLR degrading activity. The precursor protein but not the mature protein may form multimers. Interacts with APOB, VLDLR, LRP8/APOER2 and BACE1. The full length immature form (pro-PCSK9) interacts with SCNN1A, SCNN1B and SCNN1G. The pro-PCSK9 form (via C-terminal domain) interacts with LDLR

By similarity.

Subcellular location: Cytoplasm

By similarity. Secreted

By similarity. Endosome

By similarity. Lysosome

By similarity. Cell surface

By similarity. Endoplasmic reticulum

By similarity. Golgi apparatus

By similarity. Note: Autocatalytic cleavage is required to transport it from the endoplasmic reticulum to the Golgi apparatus and for the secretion of the mature protein. Localizes to the endoplasmic reticulum in the absence of LDLR and co-localizes to the cell surface and to the endosomes/lysosomes in the presence of LDLR. The sorting to the cell surface and endosomes is required in order to fully promote LDLR degradation

By similarity.

Domain: The C-terminal domain (CRD) is essential for the LDLR-binding and degrading activities

By similarity.The catalytic domain is responsible for mediating its self-association

By similarity.

Post-translational modification: Cleavage by furin and PCSK5 generates a truncated inactive protein that is unable to induce LDLR degradation

By similarity.Undergoes autocatalytic cleavage in the endoplasmic reticulum to release the propeptide from the N-terminus and the cleavage of the propeptide is strictly required for its maturation and activation. The cleaved propeptide however remains associated with the catalytic domain through non-covalent interactions, preventing potential substrates from accessing its active site. As a result, it is secreted from cells as a propeptide-containing, enzymatically inactive protein

By similarity.Phosphorylation protects the propeptide against proteolysis

By similarity.

Sequence similarities: Belongs to the peptidase S8 family.Contains 1 peptidase S8 domain.
Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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