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PELI2 blocking peptide

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Catalog # MBS9219445
Unit / Price
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  0.1 mg  /  $155 +1 FREE 8GB USB
PELI2 blocking peptide
Product Name

PELI2, Blocking Peptide

Popular Item
Full Product Name

PELI2 Antibody (N-term) Blocking peptide

Product Synonym Names
E3 ubiquitin-protein ligase pellino homolog 2; Pellino-2; 632-; PELI2
Antibody/Peptide Pairs
PELI2 peptide (MBS9219445) is used for blocking the activity of PELI2 antibody (MBS9205376)
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
OMIM
614798
3D Structure
ModBase 3D Structure for Q9HAT8
Form/Format
Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.
Preparation and Storage
Maintain refrigerated at 2-8 degree C for up to 6 months. For long term storage store at -20 degree C.
Other Notes
Small volumes of PELI2 blocking peptide vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Related Product Information for
PELI2 blocking peptide
E3 ubiquitin ligase catalyzing the covalent attachment of ubiquitin moieties onto substrate proteins. Involved in the TLR and IL-1 signaling pathways via interaction with the complex containing IRAK kinases and TRAF6. Mediates IL1B-induced IRAK1 'Lys-63'-linked polyubiquitination and possibly 'Lys-48'-linked ubiquitination. May be important for LPS- and IL1B-induced MAP3K7- dependent, but not MAP3K3-dependent, NF-kappa-B activation. Can activate the MAP (mitogen activated protein) kinase pathway leading to activation of ELK1.
NCBI/Uniprot data below describe general gene information for PELI2. It may not necessarily be applicable to this product.
NCBI GI #
NCBI GeneID
NCBI Accession #
UniProt Primary Accession #
UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
46,435 Da
NCBI Official Full Name
E3 ubiquitin-protein ligase pellino homolog 2
NCBI Official Synonym Full Names
pellino E3 ubiquitin protein ligase family member 2
NCBI Official Symbol
PELI2  [Similar Products]
NCBI Protein Information
E3 ubiquitin-protein ligase pellino homolog 2
UniProt Protein Name
E3 ubiquitin-protein ligase pellino homolog 2
UniProt Gene Name
PELI2  [Similar Products]
UniProt Synonym Gene Names
Pellino-2  [Similar Products]
UniProt Entry Name
PELI2_HUMAN
UniProt Comments for PELI2
PELI2: E3 ubiquitin ligase catalyzing the covalent attachment of ubiquitin moieties onto substrate proteins. Involved in the TLR and IL-1 signaling pathways via interaction with the complex containing IRAK kinases and TRAF6. Mediates 'Lys-63'-linked polyubiquitination of IRAK1. Can activate the MAP (mitogen activated protein) kinase pathway leading to activation of ELK1. Not required for NF-kappa-B activation. Belongs to the pellino family.

Protein type: Ubiquitin conjugating system; Adaptor/scaffold; EC 6.3.2.-; EC 6.3.2.19; Ubiquitin ligase

Chromosomal Location of Human Ortholog: 14q21

Cellular Component: cytosol

Molecular Function: protein binding

Biological Process: positive regulation of I-kappaB kinase/NF-kappaB cascade; positive regulation of MAPKKK cascade; positive regulation of protein amino acid phosphorylation
Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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