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PELI2 recombinant protein

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Catalog # MBS205987
Unit / Price
  0.05 mg  /  $310 +1 FREE 8GB USB
  0.25 mg  /  $720 +1 FREE 8GB USB
SDS-Page
Product Name

PELI2, Recombinant Protein

Popular Item
Also Known As

PELI2, 1-420aa, Human, His tag, E Coli

Product Synonym Names
E3 ubiquitin-protein ligase pellino homolog 2; PELI2 - pellino E3; Pellino-2
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
Sequence Length
420
Sequence
MGSSHHHHHH SSGLVPRGSH MGSMFSPGQE EHCAPNKEPV KYGELVVLGY NGALPNGDRG RRKSRFALYK RPKANGVKPS TVHVISTPQA SKAISCKGQH SISYTLSRNQ TVVVEYTHDK DTDMFQVGRS TESPIDFVVT DTISGSQNTD EAQITQSTIS RFACRIVCDR NEPYTARIFA AGFDSSKNIF LGEKAAKWKN PDGHMDGLTT NGVLVMHPRG GFTEESQPGV WREISVCGDV YTLRETRSAQ QRGKLVESET NVLQDGSLID LCGATLLWRT ADGLFHTPTQ KHIEALRQEI NAARPQCPVG LNTLAFPSIN RKEVVEEKQP WAYLSCGHVH GYHNWGHRSD TEANERECPM CRTVGPYVPL WLGCEAGFYV DAGPPTHAFT PCGHVCSEKS AKYWSQIPLP HGTHAFHAAC PFCATQLVGE QNCIKLIFQG PID
OMIM
AF302502 mRNA
3D Structure
ModBase 3D Structure for Q9HAT8
Host
E Coli
Purity/Purification
> 80% by SDS-PAGE
Form/Format
Liquid. In 20mM Tris-HCl Buffer (pH 8.0) containing 0.15M NaCl, 20% glycerol, 1mM DTT
Concentration
0.5 mg/ml (determined by Bradford assay) (lot specific)
Antigen Species
Human
Tag Information
His-tag
Preparation and Storage
Can be stored at 4 degree C short term (1-2 weeks).
For long term storage, aliquot and store at -20 degree C or -70 degree C.
Avoid repeated freezing and thawing cycles.
Other Notes
Small volumes of PELI2 recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Related Product Information for
PELI2 recombinant protein
PELI2 is an E3 ubiquitin ligase catalyzing the covalent attachment of ubiquitin moieties onto substrate proteins. This protein is involved in the TLR and IL-1 signaling pathways via interaction with the complex containing IRAK kinases and TRAF6. It mediates IL1B-induced IRAK1 'Lys-63'-linked polyubiquitination and possibly 'Lys-48'-linked ubiquitination. PELI2 may be important for LPS- and IL1B-induced MAP3K7-dependent, but not MAP3K3-dependent, NF-kappa-B activation. It can activate the MAP (mitogen activated protein) kinase pathway leading to activation of ELK1. Recombinant human PELI2 protein, fused to His-tag at N-terminus, was expressed in E Coli and purified by using conventional chromatography techniques.
Product Categories/Family for PELI2 recombinant protein
Applications Tested/Suitable for PELI2 recombinant protein
SDS-PAGE

NCBI/Uniprot data below describe general gene information for PELI2. It may not necessarily be applicable to this product.
NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
UniProt Primary Accession #
UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
48.8 kDa (443aa) confirmed by MALDI-TOF
NCBI Official Full Name
E3 ubiquitin-protein ligase pellino homolog 2
NCBI Official Synonym Full Names
pellino E3 ubiquitin protein ligase family member 2
NCBI Official Symbol
PELI2  [Similar Products]
NCBI Protein Information
E3 ubiquitin-protein ligase pellino homolog 2
UniProt Protein Name
E3 ubiquitin-protein ligase pellino homolog 2
UniProt Synonym Protein Names
RING-type E3 ubiquitin transferase pellino homolog 2Curated
UniProt Gene Name
PELI2  [Similar Products]
UniProt Synonym Gene Names
Pellino-2  [Similar Products]
UniProt Comments for PELI2
E3 ubiquitin ligase catalyzing the covalent attachment of ubiquitin moieties onto substrate proteins. Involved in the TLR and IL-1 signaling pathways via interaction with the complex containing IRAK kinases and TRAF6. Mediates IL1B-induced IRAK1 'Lys-63'-linked polyubiquitination and possibly 'Lys-48'-linked ubiquitination. May be important for LPS- and IL1B-induced MAP3K7-dependent, but not MAP3K3-dependent, NF-kappa-B activation. Can activate the MAP (mitogen activated protein) kinase pathway leading to activation of ELK1.
Product References and Citations for PELI2 recombinant protein
Jensen L.E., et al (2003). FEBS Lett. 545:199-202; Strelow A., et al (2003). FEBS Lett. 547:157-161

Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
Diseases associated with PELI2 recombinant protein
Organs/Tissues associated with PELI2 recombinant protein
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