BC008964
[Other Products]
UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
90,203 Da
NCBI Official Full Name
Homo sapiens phosphofructokinase, liver, mRNA
NCBI Official Synonym Full Names
phosphofructokinase, liver type
NCBI Protein Information
ATP-dependent 6-phosphofructokinase, liver type
UniProt Protein Name
ATP-dependent 6-phosphofructokinase, liver type
UniProt Synonym Protein Names
6-phosphofructokinase type B; Phosphofructo-1-kinase isozyme B; PFK-B; Phosphohexokinase
UniProt Synonym Gene Names
UniProt Entry Name
PFKAL_HUMAN
NCBI Summary for PFKL
This gene encodes the liver (L) subunit of an enzyme that catalyzes the conversion of D-fructose 6-phosphate to D-fructose 1,6-bisphosphate, which is a key step in glucose metabolism (glycolysis). This enzyme is a tetramer that may be composed of different subunits encoded by distinct genes in different tissues. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Mar 2014]
UniProt Comments for PFKL
PFKL: phosphofructokinase, liver type. An ubiquitous metabolic enzyme involved in the synthesis and degradation of fructose 2,6-bisphosphate. Key control step of glycolysis. An allosteric enzyme activated by ADP, AMP, or fructose bisphosphate and inhibited by ATP or citrate. Activity: ATP D-fructose 6-phosphate = ADP D-fructose 1,6-bisphosphate. The holoenzyme consists of 4 subunits. The liver and muscle enzymes are homo-tetramers of four liver or muscle isoforms, respectively. The red blood cell enzyme consists hetero-tetramers of the muscle and liver isoforms. A subunit composition with a higher proportion of platelet type subunits is found in platelets, brain and fibroblasts. Two alternatively spliced isoforms have been described.
Protein type: EC 2.7.1.11; Carbohydrate Metabolism - fructose and mannose; Carbohydrate Metabolism - glycolysis and gluconeogenesis; Carbohydrate Metabolism - galactose; Carbohydrate Metabolism - pentose phosphate pathway; Kinase, other
Chromosomal Location of Human Ortholog: 21q22.3
Cellular Component: 6-phosphofructokinase complex; cytosol; membrane
Molecular Function: 6-phosphofructokinase activity; ATP binding; identical protein binding; kinase binding; protein binding
Biological Process: fructose 1,6-bisphosphate metabolic process; fructose 6-phosphate metabolic process; glycolysis; protein oligomerization; response to glucose stimulus
Research Articles on PFKL
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Pathways associated with PFKL cdna clone
Diseases associated with PFKL cdna clone
Organs/Tissues associated with PFKL cdna clone
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