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PGHS-1 protein

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Catalog # MBS483007
Unit / Price
  0.01 mg  /  $195 +1 FREE 8GB USB
PGHS-1 protein
Product Name

PGHS-1, Protein

Popular Item
Also Known As

PGHS-1 Standard, Native Ovine

Product Synonym Names
Native Ovine Prostaglandin H Synthase-1 Standard
Product Gene Name
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
Sequence Length
562
OMIM
176805
3D Structure
ModBase 3D Structure for P23219
Host
Ovine seminal vesicles
Purity/Purification
Greater than 95% by electrophoresis
Concentration
0.1 mg/mL. (lot specific)
Contents
10 mug of protein in 100 muL
Preparation and Storage
Stable for several months at At -20 degree C, and indefinitely at At -70 degree C.
Other Notes
Small volumes of PGHS-1 protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
NCBI/Uniprot data below describe general gene information for PGHS-1. It may not necessarily be applicable to this product.
NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
UniProt Primary Accession #
UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
72,010 Da
NCBI Official Full Name
prostaglandin G/H synthase 1 isoform 2
NCBI Official Synonym Full Names
prostaglandin-endoperoxide synthase 1 (prostaglandin G/H synthase and cyclooxygenase)
NCBI Official Symbol
PTGS1  [Similar Products]
NCBI Official Synonym Symbols
COX1; COX3; PHS1; PCOX1; PES-1; PGHS1; PTGHS; PGG/HS; PGHS-1
  [Similar Products]
NCBI Protein Information
prostaglandin G/H synthase 1; PGH synthase 1; cyclooxygenase-1; prostaglandin H2 synthase 1
UniProt Protein Name
Prostaglandin G/H synthase 1
UniProt Synonym Protein Names
Cyclooxygenase-1; COX-1; Prostaglandin H2 synthase 1; PGH synthase 1; PGHS-1; PHS 1; Prostaglandin-endoperoxide synthase 1
UniProt Gene Name
PTGS1  [Similar Products]
UniProt Synonym Gene Names
COX1; COX-1; PGH synthase 1; PGHS-1; PHS 1  [Similar Products]
UniProt Entry Name
PGH1_HUMAN
NCBI Summary for PGHS-1
This is one of two genes encoding similar enzymes that catalyze the conversion of arachinodate to prostaglandin. The encoded protein regulates angiogenesis in endothelial cells, and is inhibited by nonsteroidal anti-inflammatory drugs such as aspirin. Based on its ability to function as both a cyclooxygenase and as a peroxidase, the encoded protein has been identified as a moonlighting protein. The protein may promote cell proliferation during tumor progression. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2014]
UniProt Comments for PGHS-1
COX-1: May play an important role in regulating or promoting cell proliferation in some normal and neoplastically transformed cells. Homodimer. Belongs to the prostaglandin G/H synthase family. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Lipid Metabolism - arachidonic acid; EC 1.14.99.1; Oxidoreductase

Chromosomal Location of Human Ortholog: 9q32-q33.3

Cellular Component: endoplasmic reticulum membrane; photoreceptor outer segment; intracellular membrane-bound organelle; cytoplasm; nucleus

Molecular Function: prostaglandin-endoperoxide synthase activity; peroxidase activity; dioxygenase activity; metal ion binding; heme binding

Biological Process: xenobiotic metabolic process; regulation of blood pressure; cyclooxygenase pathway; arachidonic acid metabolic process; lipid metabolic process; response to oxidative stress; inflammatory response; prostaglandin biosynthetic process; regulation of cell proliferation
Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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