NP_000951.1
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NCBI GenBank Nucleotide #
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UniProt Related Accession #
Molecular Weight
40,956 Da
NCBI Official Full Name
prostacyclin receptor
NCBI Official Synonym Full Names
prostaglandin I2 (prostacyclin) receptor (IP)
NCBI Official Synonym Symbols
NCBI Protein Information
prostacyclin receptor; PGI receptor; PGI2 receptor; prostanoid IP receptor; prostaglandin I2 receptor
UniProt Protein Name
Prostacyclin receptor
UniProt Synonym Protein Names
Prostaglandin I2 receptor; PGI receptor; PGI2 receptor; Prostanoid IP receptor
UniProt Synonym Gene Names
UniProt Entry Name
PI2R_HUMAN
NCBI Summary for PGI2
The protein encoded by this gene is a member of the G-protein coupled receptor family 1 and has been shown to be a receptor for prostacyclin. Prostacyclin, the major product of cyclooxygenase in macrovascular endothelium, elicits a potent vasodilation and inhibition of platelet aggregation through binding to this receptor. [provided by RefSeq, Jul 2008]
UniProt Comments for PGI2
PTGIR: Receptor for prostacyclin (prostaglandin I2 or PGI2). The activity of this receptor is mediated by G(s) proteins which activate adenylate cyclase. Belongs to the G-protein coupled receptor 1 family.
Protein type: Receptor, GPCR; Membrane protein, integral; GPCR, family 1; Membrane protein, multi-pass
Chromosomal Location of Human Ortholog: 19q13.3
Cellular Component: integral to plasma membrane; plasma membrane; cytosol
Molecular Function: G-protein coupled receptor activity; guanyl-nucleotide exchange factor activity
Biological Process: G-protein signaling, coupled to cyclic nucleotide second messenger; cell-cell signaling; negative regulation of smooth muscle cell proliferation; positive regulation of cAMP biosynthetic process; response to lipopolysaccharide; blood coagulation; G-protein signaling, adenylate cyclase activating pathway; positive regulation of GTPase activity
Research Articles on PGI2
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Products associated with PGI2 elisa kit
Pathways associated with PGI2 elisa kit
Diseases associated with PGI2 elisa kit
Organs/Tissues associated with PGI2 elisa kit
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