• Call +1.858.633.0165 or Fax +1.858.633.0166 or Contact Us

MyBioSource - Phospho-specific Antibodies

MyBioSource Phospho-specific Antibodies Catalog Description

Phosphorylation is a key, reversible post-translational protein modification. It is the most common mechanism known for regulating protein function and many proteins have phosphoforms. The field of phosphoproteomics, a branch of proteomics, is dedicated to identifying, cataloging and characterizing proteins having one of more phosphate groups as a post-translational modification. However, researchers in every branch of science are interested in phosphorylation status and seek high quality, sensitive phosphospecific antibodies.

Several decades ago, the increasing recognition of the importance of protein phosphorylation led to a demand for research tools for specifically detecting the phosphorylated forms of proteins. This spurred the development of phosphospecific antibodies. The first phosphospecific antibodies were described in the 1980's, and the 1990's saw the development of more targeted approaches to develop sequence-specific phosphospecific polyclonal and monoclonal antibodies targeting specific phosphosites or putative phosphosites of a protein.

Phosphospecific antibodies continue to have key roles in showing that the tight regulation of phosphorylation statuses of proteins is essential for homeostasis and integral cellular processes such as cell growth and the cell cycle, as well as apoptosis and other cell death processes. They are helping us to understand that dysregulation of phosphorylation is associated with a myriad of diseases, among them cancer where constitutive phosphorylation can be associated with uncontrolled cellular proliferation.

Phosphospecific antibodies are commercially available for most of the common and even not so common targets researchers are studying.

Your search does not match any products or documents.

Please click here to contact us and request the product or submit your request for:

Custom ELISA Kits, Recombinant Proteins and Antibodies can be designed, manufactured and produced according to the researcher's specifications.

Search suggestions:

  • The search term must be at least 2 characters long.
  • Make sure all words are spelled correctly.
  • Try different keywords.
  • Try more general keywords or fewer keywords.
  • Try different combinations of search option.
Request a Quote

Please fill out the form below and our representative will get back to you shortly.

MBS000000
Contact Us

Please fill out the form below and our representative will get back to you shortly.

MBS000000