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PIK3R1 recombinant protein :: Phosphatidylinositol 3-kinase regulatory subunit alpha (PIK3R1) Recombinant Protein

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Catalog # MBS717874
Unit / Price
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  0.05 mg (E-Coli)  /  $1,155 +1 FREE 8GB USB
  0.05 mg (Yeast)  /  $1,165 +1 FREE 8GB USB
  0.05 mg (Baculovirus)  /  $1,400 +1 FREE 8GB USB
  0.2 mg (E-Coli)  /  $1,560 +1 FREE 8GB USB
  0.2 mg (Yeast)  /  $1,585 +1 FREE 8GB USB
  0.05 mg (Mammalian-Cell)  /  $1,645 +2 FREE 8GB USB
  0.5 mg (E-Coli)  /  $1,720 +2 FREE 8GB USB
  0.5 mg (Yeast)  /  $1,800 +2 FREE 8GB USB
  0.1 mg (Baculovirus)  /  $2,030 +2 FREE 8GB USB
  1 mg (E-Coli)  /  $2,590 +3 FREE 8GB USB
  0.5 mg (Baculovirus)  /  $2,600 +3 FREE 8GB USB
  0.1 mg (Mammalian-Cell)  /  $2,625 +3 FREE 8GB USB
  1 mg (Yeast)  /  $2,835 +3 FREE 8GB USB
  1 mg (Baculovirus)  /  $4,015 +5 FREE 8GB USB
PIK3R1 recombinant protein
Product Name

Phosphatidylinositol 3-kinase regulatory subunit alpha (PIK3R1), Recombinant Protein

Full Product Name

Recombinant Human Phosphatidylinositol 3-kinase regulatory subunit alpha (PIK3R1)

Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
Sequence Positions
2-724aa, Full Length of Mature Protein
Sequence
SAEGYQYRAL YDYKKEREED IDLHLGDILT VNKGSLVALG FSDGQEARPE EIGWLNGYNE TTGERGDFPG TYVEYIGRKK ISPPTPKPRP PRPLPVAPGS SKTEADVEQQ ALTLPDLAEQ FAPPDIAPPL LIKLVEAIEK KGLECSTLYR TQSSSNLAEL RQLLDCDTPS VDLEMIDVHV LADAFKRYLL DLPNPVIPAA VYSEMISLAP EVQSSEEYIQ LLKKLIRSPS IPHQYWLTLQ YLLKHFFKLS QTSSKNLLNA RVLSEIFSPM LFRFSAASSD NTENLIKVIE ILISTEWNER QPAPALPPKP PKPTTVANNG MNNNMSLQDA EWYWGDISRE EVNEKLRDTA DGTFLVRDAS TKMHGDYTLT LRKGGNNKLI KIFHRDGKYG FSDPLTFSSV VELINHYRNE SLAQYNPKLD VKLLYPVSKY QQDQVVKEDN IEAVGKKLHE YNTQFQEKSR EYDRLYEEYT RTSQEIQMKR TAIEAFNETI KIFEEQCQTQ ERYSKEYIEK FKREGNEKEI QRIMHNYDKL KSRISEIIDS RRRLEEDLKK QAAEYREIDK RMNSIKPDLI QLRKTRDQYL MWLTQKGVRQ KKLNEWLGNE NTEDQYSLVE DDEDLPHHDE KTWNVGSSNR NKAENLLRGK RDGTFLVRES SKQGCYACSV VVDGEVKHCV INKTATGYGF AEPYNLYSSL KELVLHYQHT SLVQHNDSLN VTLAYPVYAQ QRR
OMIM
171833
3D Structure
ModBase 3D Structure for P27986
Host
E Coli or Yeast or Baculovirus or Mammalian Cell
Purity/Purification
>85% (SDS-PAGE) (lot specific)
Form/Format
Liquid containing glycerol
Tag Information
This protein contains an N-terminal tag and may also contain a C-terminal tag. Tag types are determined by various factors including tag-protein stability, please inquire for tag information.
Sterility
Sterile filter available upon request.
Endotoxin
Low endotoxin available upon request.
Species
Human
Storage Buffer
Tris-based buffer, 50% glycerol
Preparation and Storage
Store at -20 degrees C. For long-term storage, store at -20 degrees C or -80 degrees C. Store working aliquots at 4 degrees C for up to one week. Repeated freezing and thawing is not recommended.
ISO Certification
Manufactured in an ISO 13485:2003 and EN ISO 13485:2012 Certified Laboratory.
Other Notes
Small volumes of PIK3R1 recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Related Product Information for
PIK3R1 recombinant protein
Phosphatidylinositol 3-kinase phosphorylates the inositol ring of phosphatidylinositol at the 3-prime position. The enzyme comprises a 110 kD catalytic subunit and a regulatory subunit of either 85, 55, or 50 kD. This gene encodes the 85 kD regulatory subunit. Phosphatidylinositol 3-kinase plays an important role in the metabolic actions of insulin, and a mutation in this gene has been associated with insulin resistance. Alternative splicing of this gene results in three transcript variants encoding different isoforms.
NCBI/Uniprot data below describe general gene information for PIK3R1. It may not necessarily be applicable to this product.
NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
UniProt Primary Accession #
UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
42,838 Da
NCBI Official Full Name
phosphatidylinositol 3-kinase regulatory subunit alpha isoform 4
NCBI Official Synonym Full Names
phosphoinositide-3-kinase regulatory subunit 1
NCBI Official Symbol
PIK3R1  [Similar Products]
NCBI Official Synonym Symbols
p85; AGM7; GRB1; IMD36; p85-ALPHA
  [Similar Products]
NCBI Protein Information
phosphatidylinositol 3-kinase regulatory subunit alpha
UniProt Protein Name
Phosphatidylinositol 3-kinase regulatory subunit alpha
UniProt Synonym Protein Names
Phosphatidylinositol 3-kinase 85 kDa regulatory subunit alpha; PI3-kinase subunit p85-alpha; PtdIns-3-kinase regulatory subunit p85-alpha
UniProt Gene Name
PIK3R1  [Similar Products]
UniProt Synonym Gene Names
GRB1; PI3-kinase regulatory subunit alpha; PI3K regulatory subunit alpha; PtdIns-3-kinase regulatory subunit alpha; PI3-kinase subunit p85-alpha; PtdIns-3-kinase regulatory subunit p85-alpha  [Similar Products]
NCBI Summary for PIK3R1
Phosphatidylinositol 3-kinase phosphorylates the inositol ring of phosphatidylinositol at the 3-prime position. The enzyme comprises a 110 kD catalytic subunit and a regulatory subunit of either 85, 55, or 50 kD. This gene encodes the 85 kD regulatory subunit. Phosphatidylinositol 3-kinase plays an important role in the metabolic actions of insulin, and a mutation in this gene has been associated with insulin resistance. Alternative splicing of this gene results in four transcript variants encoding different isoforms. [provided by RefSeq, Jun 2011]
UniProt Comments for PIK3R1
Binds to activated (phosphorylated) protein-Tyr kinases, through its SH2 domain, and acts as an adapter, mediating the association of the p110 catalytic unit to the plasma membrane. Necessary for the insulin-stimulated increase in glucose uptake and glycogen synthesis in insulin-sensitive tissues. Plays an important role in signaling in response to FGFR1, FGFR2, FGFR3, FGFR4, KITLG/SCF, KIT, PDGFRA and PDGFRB. Likewise, plays a role in ITGB2 signaling (PubMed:17626883, PubMed:19805105, PubMed:7518429). Modulates the cellular response to ER stress by promoting nuclear translocation of XBP1 isoform 2 in a ER stress- and/or insulin-dependent manner during metabolic overloading in the liver and hence plays a role in glucose tolerance improvement (PubMed:20348923).
Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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