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PIKFYVE recombinant protein :: 1-phosphatidylinositol 3-phosphate 5-kinase (PIKFYVE) Recombinant Protein

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Catalog # MBS1462118
Unit / Price
Scan QR to view Datasheet
  0.05 mg (E-Coli)  /  $855 +1 FREE 8GB USB
  0.05 mg (Yeast)  /  $950 +1 FREE 8GB USB
  0.2 mg (E-Coli)  /  $1,145 +1 FREE 8GB USB
  0.05 mg (Baculovirus)  /  $1,160 +1 FREE 8GB USB
  0.5 mg (E-Coli)  /  $1,265 +1 FREE 8GB USB
  0.2 mg (Yeast)  /  $1,280 +1 FREE 8GB USB
  0.05 mg (Mammalian-Cell)  /  $1,405 +1 FREE 8GB USB
  0.5 mg (Yeast)  /  $1,450 +1 FREE 8GB USB
  0.1 mg (Baculovirus)  /  $1,680 +2 FREE 8GB USB
  1 mg (E-Coli)  /  $1,915 +2 FREE 8GB USB
  0.5 mg (Baculovirus)  /  $2,185 +2 FREE 8GB USB
  0.1 mg (Mammalian-Cell)  /  $2,275 +2 FREE 8GB USB
  1 mg (Yeast)  /  $2,290 +2 FREE 8GB USB
  1 mg (Baculovirus)  /  $3,370 +4 FREE 8GB USB
PIKFYVE recombinant protein
Product Name

1-phosphatidylinositol 3-phosphate 5-kinase (PIKFYVE), Recombinant Protein

Full Product Name

Recombinant Human 1-phosphatidylinositol 3-phosphate 5-kinase (PIKFYVE) , partial

Product Synonym Gene Name
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
Sequence Positions
1-440. Partial
Sequence
MATDDKTSPT LDSANDLPRS PTSPSHLTHF KPLTPDQDEP PFKSAYSSFV NLFRFNKERA EGGQGEQQPL SGSWTSPQLP SRTQSVRSPT PYKKQLNEEL QRRSSALDTR RKAEPTFGGH DPRTAVQLRS LSTVLKRLKE IMEGKSQDSD LKQYWMPDSQ CKECYDCSEK FTTFRRRHHC RLCGQIFCSR CCNQEIPGKF MGYTGDLRAC TYCRKIALSY AHSTDSNSIG EDLNALSDSA CSVSVLDPSE PRTPVGSRKA SRNIFLEDDL AWQSLIHPDS SNTPLSTRLV SVQEDAGKSP ARNRSASITN LSLDRSGSPM VPSYETSVSP QANRTYVRTE TTEDERKILL DSVQLKDLWK KICHHSSGME FQDHRYWLRT HPNCIVGKEL VNWLIRNGHI ATRAQAIAIG QAMVDGRWLD CVSHHDQLFR DEYALYRPLQ
OMIM
121850
3D Structure
ModBase 3D Structure for Q9Y2I7
Host
E Coli or Yeast or Baculovirus or Mammalian Cell
Purity/Purification
>85% (SDS-PAGE) (lot specific)
Form/Format
Liquid containing glycerol
Tag Information
This protein contains an N-terminal tag and may also contain a C-terminal tag. Tag types are determined by various factors including tag-protein stability, please inquire for tag information.
Sterility
Sterile filter available upon request.
Endotoxin
Low endotoxin available upon request.
Species
Human
Storage Buffer
Tris-based buffer, 50% glycerol
Tag Information
Tag type will be determined during the manufacturing process
Preparation and Storage
Store at -20 degrees C. For long-term storage, store at -20 degrees C or -80 degrees C. Store working aliquots at 4 degrees C for up to one week. Repeated freezing and thawing is not recommended.
ISO Certification
Manufactured in an ISO 9001:2008 Certified Laboratory.
Other Notes
Small volumes of PIKFYVE recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
NCBI/Uniprot data below describe general gene information for PIKFYVE. It may not necessarily be applicable to this product.
NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
UniProt Primary Accession #
UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
61,595 Da
NCBI Official Full Name
1-phosphatidylinositol 3-phosphate 5-kinase isoform 4
NCBI Official Synonym Full Names
phosphoinositide kinase, FYVE-type zinc finger containing
NCBI Official Symbol
PIKFYVE  [Similar Products]
NCBI Official Synonym Symbols
CFD; FAB1; HEL37; PIP5K; PIP5K3; ZFYVE29
  [Similar Products]
NCBI Protein Information
1-phosphatidylinositol 3-phosphate 5-kinase
UniProt Protein Name
1-phosphatidylinositol 3-phosphate 5-kinase
UniProt Synonym Protein Names
FYVE finger-containing phosphoinositide kinase; PIKfyve; Phosphatidylinositol 3-phosphate 5-kinase type III; PIPkin-III; Type III PIP kinase
UniProt Gene Name
PIKFYVE  [Similar Products]
UniProt Synonym Gene Names
KIAA0981; PIP5K3; Phosphatidylinositol 3-phosphate 5-kinase; PIPkin-III; Type III PIP kinase  [Similar Products]
NCBI Summary for PIKFYVE
Phosphorylated derivatives of phosphatidylinositol (PtdIns) regulate cytoskeletal functions, membrane trafficking, and receptor signaling by recruiting protein complexes to cell- and endosomal-membranes. Humans have multiple PtdIns proteins that differ by the degree and position of phosphorylation of the inositol ring. This gene encodes an enzyme (PIKfyve; also known as phosphatidylinositol-3-phosphate 5-kinase type III or PIPKIII) that phosphorylates the D-5 position in PtdIns and phosphatidylinositol-3-phosphate (PtdIns3P) to make PtdIns5P and PtdIns(3,5)biphosphate. The D-5 position also can be phosphorylated by type I PtdIns4P-5-kinases (PIP5Ks) that are encoded by distinct genes and preferentially phosphorylate D-4 phosphorylated PtdIns. In contrast, PIKfyve preferentially phosphorylates D-3 phosphorylated PtdIns. In addition to being a lipid kinase, PIKfyve also has protein kinase activity. PIKfyve regulates endomembrane homeostasis and plays a role in the biogenesis of endosome carrier vesicles from early endosomes. Mutations in this gene cause corneal fleck dystrophy (CFD); an autosomal dominant disorder characterized by numerous small white flecks present in all layers of the corneal stroma. Histologically, these flecks appear to be keratocytes distended with lipid and mucopolysaccharide filled intracytoplasmic vacuoles. Alternative splicing results in multiple transcript variants encoding distinct isoforms.[provided by RefSeq, May 2010]
UniProt Comments for PIKFYVE
The PI(3,5)P2 regulatory complex regulates both the synthesis and turnover of phosphatidylinositol 3,5-bisphosphate (PtdIns(3,5)P2). Catalyzes the phosphorylation of phosphatidylinositol 3-phosphate on the fifth hydroxyl of the myo-inositol ring, to form phosphatidylinositol 3,5-bisphosphate. Required for endocytic-vacuolar pathway and nuclear migration. Plays a role in the biogenesis of endosome carrier vesicles (ECV)/ multivesicular bodies (MVB) transport intermediates from early endosomes.
Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
Organs/Tissues associated with PIKFYVE recombinant protein
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