ABA42095.1
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UniProt Primary Accession #
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UniProt Related Accession #
Molecular Weight
55,543 Da
NCBI Official Full Name
protein kinase B beta
NCBI Official Synonym Full Names
v-akt murine thymoma viral oncogene homolog 2
NCBI Protein Information
RAC-beta serine/threonine-protein kinase
UniProt Protein Name
RAC-beta serine/threonine-protein kinase
UniProt Synonym Protein Names
Protein kinase Akt-2; Protein kinase B beta; PKB beta; RAC-PK-beta
UniProt Synonym Gene Names
UniProt Entry Name
AKT2_RAT
NCBI Summary for PKBb
may be involved in phosphatidylinositol 3-kinase (PI3-K) mediated signaling [RGD, Feb 2006]
UniProt Comments for PKBb
Akt2: an AGC kinase. Plays critical roles in glucose metabolism and the development or maintenance of proper adipose tissue and islet mass for which other Akt/PKB isoforms are unable to fully compensate. Amplified and overexpressed in human ovarian carcinoma cell lines and amplified in some primary ovarian and pancreatic tumors. Antisense blocks invasiveness in xenografts. Expressed in several insulin-responsive tissues, and one case of Type II diabetes has been associated with a likely LOF point mutation. Mouse mutants have defects in insulin response.
Protein type: Protein kinase, AGC; EC 2.7.11.1; Protein kinase, Ser/Thr (non-receptor); Oncoprotein; Kinase, protein; AGC group; AKT family
Cellular Component: nucleoplasm; intracellular membrane-bound organelle; plasma membrane; cell cortex; cytosol; nucleus; vesicle
Molecular Function: protein serine/threonine kinase activity; protein binding; protein kinase C binding; ATP binding; protein kinase activity
Biological Process: response to muscle activity; positive regulation of nitric oxide biosynthetic process; positive regulation of positive chemotaxis; multicellular organismal development; positive regulation of glycogen biosynthetic process; intracellular protein transport across a membrane; positive regulation of vesicle fusion; negative regulation of caspase activity; protein amino acid phosphorylation; response to insulin stimulus; regulation of translation; positive regulation of glucose import; negative regulation of RNA splicing; protein kinase B signaling cascade; response to nutrient levels; glycogen biosynthetic process; positive regulation of signal transduction; carbohydrate transport; myelin maintenance in the peripheral nervous system; glucose metabolic process; response to osmotic stress; positive regulation of peptidyl-serine phosphorylation; cellular response to hormone stimulus; positive regulation of fatty acid beta-oxidation; cellular response to insulin stimulus; insulin receptor signaling pathway; positive regulation of transcription from RNA polymerase II promoter; positive regulation of protein amino acid phosphorylation; positive regulation of cell migration; negative regulation of apoptosis
Research Articles on PKBb
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Products associated with PKBb elisa kit
Pathways associated with PKBb elisa kit
Diseases associated with PKBb elisa kit
Organs/Tissues associated with PKBb elisa kit
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