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PKC-beta I protein

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Catalog # MBS483009
Unit / Price
  0.1 mg  /  $200 +1 FREE 8GB USB
PKC-beta I protein
Product Name

PKC-beta I, Protein

Also Known As

PKC-beta I Specific Peptide

Product Synonym Names
Protein Kinase C Beta I (I) Synthetic Peptide
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
Sequence Length
671
OMIM
176970
3D Structure
ModBase 3D Structure for P05771
Contents
100 mug of peptide in 500 muL of ammonium bicarbonate buffer
Preparation and Storage
Stable at 4 degree C. For long term storage, aliquot and freeze at - 20 degree C. Avoid repeated freeze/thaw cycles.
Other Notes
Small volumes of PKC-beta I protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Applications Tested/Suitable for PKC-beta I protein
Western Blot (WB)
Application Notes for PKC-beta I protein
Will compete with the anti-peptide antibody in Western blotting for confirmation of the PKC specificity of the antibody binding.
NCBI/Uniprot data below describe general gene information for PKC-beta I. It may not necessarily be applicable to this product.
NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
UniProt Primary Accession #
UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
77,012 Da
NCBI Official Full Name
protein kinase C beta type isoform 1
NCBI Official Synonym Full Names
protein kinase C, beta
NCBI Official Symbol
PRKCB  [Similar Products]
NCBI Official Synonym Symbols
PKCB; PRKCB1; PRKCB2; PKC-beta
  [Similar Products]
NCBI Protein Information
protein kinase C beta type; PKC-B; protein kinase C, beta 1 polypeptide
UniProt Protein Name
Protein kinase C beta type
UniProt Gene Name
PRKCB  [Similar Products]
UniProt Synonym Gene Names
PKCB; PRKCB1; PKC-B; PKC-beta  [Similar Products]
UniProt Entry Name
KPCB_HUMAN
NCBI Summary for PKC-beta I
Protein kinase C (PKC) is a family of serine- and threonine-specific protein kinases that can be activated by calcium and second messenger diacylglycerol. PKC family members phosphorylate a wide variety of protein targets and are known to be involved in diverse cellular signaling pathways. PKC family members also serve as major receptors for phorbol esters, a class of tumor promoters. Each member of the PKC family has a specific expression profile and is believed to play a distinct role in cells. The protein encoded by this gene is one of the PKC family members. This protein kinase has been reported to be involved in many different cellular functions, such as B cell activation, apoptosis induction, endothelial cell proliferation, and intestinal sugar absorption. Studies in mice also suggest that this kinase may also regulate neuronal functions and correlate fear-induced conflict behavior after stress. Alternatively spliced transcript variants encoding distinct isoforms have been reported. [provided by RefSeq, Jul 2008]
UniProt Comments for PKC-beta I
PKCB: an AGC kinase of the PKC family. A classical PKC downstream of many mitogenic receptors. Activates the NF-kappaB signaling pathway in B cells after antigen-receptor signaling. Two splice-variant isoforms have been described.

Protein type: EC 2.7.11.13; Protein kinase, Ser/Thr (non-receptor); Kinase, protein; Motility/polarity/chemotaxis; Protein kinase, AGC; AGC group; PKC family; Alpha subfamily

Chromosomal Location of Human Ortholog: 16p11.2

Cellular Component: nucleoplasm; membrane; cytoplasm; plasma membrane; nucleus; cytosol

Molecular Function: protein serine/threonine kinase activity; protein binding; protein kinase C activity; androgen receptor binding; ligand-dependent nuclear receptor transcription coactivator activity; protein kinase C binding; zinc ion binding; histone binding; calcium channel regulator activity; chromatin binding; ATP binding

Biological Process: platelet activation; positive regulation of I-kappaB kinase/NF-kappaB cascade; transcription, DNA-dependent; B cell activation; apoptosis; positive regulation of B cell receptor signaling pathway; mitotic nuclear envelope disassembly; negative regulation of insulin receptor signaling pathway; signal transduction; protein amino acid phosphorylation; positive regulation of vascular endothelial growth factor receptor signaling pathway; activation of NF-kappaB transcription factor; regulation of transcription from RNA polymerase II promoter; cellular calcium ion homeostasis; synaptic transmission; positive regulation of angiogenesis; B cell receptor signaling pathway; lipoprotein transport; calcium ion transport; response to hypoxia; mitotic cell cycle; blood coagulation; vascular endothelial growth factor receptor signaling pathway
Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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