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PKC-delta protein

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Catalog # MBS483014
Unit / Price
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  0.001 mg  /  $225 +1 FREE 8GB USB
PKC-delta protein
Product Name

PKC-delta, Protein

Popular Item
Full Product Name

PKC-delta Standard

Product Synonym Names
Protein Kinase C Delta Standard
Product Gene Name
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
OMIM
176977
3D Structure
ModBase 3D Structure for Q05655
Concentration
20 mug/mL (lot specific)
Contents
1.0 mug of protein in 50 muL.
Enzyme Activity
Not enzymatically active
Preparation and Storage
Stable indefinitely at At -70 degree C. or at least one year at -20 degree C.
Other Notes
Small volumes of PKC-delta protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Related Product Information for
PKC-delta protein
Description: Human recombinant kinase Cd expressed in baculoviral insect expression system. The protein is suspended in SDS/mercaptoethanol sample buffer with a bromphenol blue dye marker.
Applications Tested/Suitable for PKC-delta protein
Western Blot (WB)
Application Notes for PKC-delta protein
Intended for use as a standard for Western blots using enhanced chemiluminescence. For blots using less sensitive substrates, such as alkaline phosphatase, larger amounts of protein should be loaded onto the gel. Load 2 - 5 muL of standard directly from vial. No dilution is necessary.
NCBI/Uniprot data below describe general gene information for PKC-delta. It may not necessarily be applicable to this product.
NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
UniProt Primary Accession #
UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
80,953 Da
NCBI Official Full Name
protein kinase C delta type
NCBI Official Synonym Full Names
protein kinase C, delta
NCBI Official Symbol
PRKCD  [Similar Products]
NCBI Official Synonym Symbols
MAY1; PKCD; ALPS3; CVID9; nPKC-delta
  [Similar Products]
NCBI Protein Information
protein kinase C delta type; protein kinase C delta VIII; tyrosine-protein kinase PRKCD
UniProt Protein Name
Protein kinase C delta type
UniProt Synonym Protein Names
Tyrosine-protein kinase PRKCD (EC:2.7.10.2); nPKC-delta
UniProt Gene Name
PRKCD  [Similar Products]
UniProt Synonym Gene Names
UniProt Entry Name
KPCD_HUMAN
NCBI Summary for PKC-delta
Protein kinase C (PKC) is a family of serine- and threonine-specific protein kinases that can be activated by calcium and the second messenger diacylglycerol. PKC family members phosphorylate a wide variety of protein targets and are known to be involved in diverse cellular signaling pathways. PKC family members also serve as major receptors for phorbol esters, a class of tumor promoters. Each member of the PKC family has a specific expression profile and is believed to play distinct roles in cells. The protein encoded by this gene is one of the PKC family members. Studies both in human and mice demonstrate that this kinase is involved in B cell signaling and in the regulation of growth, apoptosis, and differentiation of a variety of cell types. Alternatively spliced transcript variants encoding the same protein have been observed. [provided by RefSeq, Jul 2008]
UniProt Comments for PKC-delta
PKCD: an AGC kinase of the PKC family. A novel PKC: Ca2 independent but still regulated by PS, DAG and phorbol esters. Caspase-3 appears to liberate a sphingosine-activated catalytic fragment that has altered regulatory mechanisms and substrate specificities.

Protein type: Protein kinase, AGC; Nuclear receptor co-regulator; Kinase, protein; Protein kinase, Ser/Thr (non-receptor); Tumor suppressor; EC 2.7.11.13; AGC group; PKC family; Delta subfamily

Chromosomal Location of Human Ortholog: 3p21.31

Cellular Component: nucleoplasm; nuclear matrix; mitochondrion; perinuclear region of cytoplasm; endoplasmic reticulum; cytoplasm; plasma membrane; intercellular junction; nucleus; cytosol

Molecular Function: calcium-independent protein kinase C activity; protein serine/threonine kinase activity; protein binding; protein kinase C activity; enzyme binding; metal ion binding; insulin receptor substrate binding; enzyme activator activity; non-membrane spanning protein tyrosine kinase activity; ATP binding

Biological Process: B cell proliferation; negative regulation of MAP kinase activity; interleukin-12 production; peptidyl-tyrosine phosphorylation; nerve growth factor receptor signaling pathway; apoptosis; negative regulation of insulin receptor signaling pathway; signal transduction; protein amino acid phosphorylation; positive regulation of protein amino acid dephosphorylation; negative regulation of filopodium formation; positive regulation of superoxide release; regulation of receptor activity; negative regulation of protein binding; cell structure disassembly during apoptosis; epidermal growth factor receptor signaling pathway; platelet activation; negative regulation of peptidyl-tyrosine phosphorylation; fibroblast growth factor receptor signaling pathway; neutrophil activation; protein stabilization; negative regulation of actin filament polymerization; cytokine and chemokine mediated signaling pathway; peptidyl-threonine phosphorylation; cell cycle; phospholipase C activation; negative regulation of inflammatory response; defense response to bacterium; interleukin-10 production; innate immune response; gene expression; immunoglobulin mediated immune response; vascular endothelial growth factor receptor signaling pathway; blood coagulation; induction of apoptosis by oxidative stress

Disease: Autoimmune Lymphoproliferative Syndrome, Type Iii
Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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