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PKC-epsilon protein

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Catalog # MBS483015
Unit / Price
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  0.1 mg  /  $210 +1 FREE 8GB USB
PKC-epsilon protein
Product Name

PKC-epsilon, Protein

Popular Item
Full Product Name

PKC-epsilon Specific Peptide

Product Synonym Names
Protein Kinase C Epsilon Synthetic Peptide
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
Sequence
Distinct region of protein kinase Cepsi lon C-terminal .
Seque nce: NH2-C-N-Q -E-E-F-K-G -F-S-Y-F-G -E-D-COOH
OMIM
176975
3D Structure
ModBase 3D Structure for Q02156
Contents
100 mug of peptide in 500 uL of ammonium bicarbonate buffer
Preparation and Storage
Stable at 4 degree C. For long term storage, aliquot product and freeze at At -20 degree C. Avoid repeated freeze/thaw cycles.
Other Notes
Small volumes of PKC-epsilon protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Applications Tested/Suitable for PKC-epsilon protein
Western Blot (WB)
Application Notes for PKC-epsilon protein
Will compete with the anti-peptide antibody in Western blotting for confirmation of the PKC specificity of the antibody binding.
NCBI/Uniprot data below describe general gene information for PKC-epsilon. It may not necessarily be applicable to this product.
NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
UniProt Primary Accession #
UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
83,674 Da
NCBI Official Full Name
protein kinase C epsilon type
NCBI Official Synonym Full Names
protein kinase C, epsilon
NCBI Official Symbol
PRKCE  [Similar Products]
NCBI Official Synonym Symbols
PKCE; nPKC-epsilon
  [Similar Products]
NCBI Protein Information
protein kinase C epsilon type
UniProt Protein Name
Protein kinase C epsilon type
UniProt Synonym Protein Names
nPKC-epsilon
UniProt Gene Name
PRKCE  [Similar Products]
UniProt Synonym Gene Names
UniProt Entry Name
KPCE_HUMAN
NCBI Summary for PKC-epsilon
Protein kinase C (PKC) is a family of serine- and threonine-specific protein kinases that can be activated by calcium and the second messenger diacylglycerol. PKC family members phosphorylate a wide variety of protein targets and are known to be involved in diverse cellular signaling pathways. PKC family members also serve as major receptors for phorbol esters, a class of tumor promoters. Each member of the PKC family has a specific expression profile and is believed to play a distinct role in cells. The protein encoded by this gene is one of the PKC family members. This kinase has been shown to be involved in many different cellular functions, such as neuron channel activation, apoptosis, cardioprotection from ischemia, heat shock response, as well as insulin exocytosis. Knockout studies in mice suggest that this kinase is important for lipopolysaccharide (LPS)-mediated signaling in activated macrophages and may also play a role in controlling anxiety-like behavior. [provided by RefSeq, Jul 2008]
UniProt Comments for PKC-epsilon
PKCE: an AGC kinase of the PKC family. Calcium-independent, phospholipid-dependent. Activated by inflammatory mediators and involved in nociceptive functions. PKC-epsilon null mice display decreased hypoxic pulmonary vasoconstriction.

Protein type: Protein kinase, Ser/Thr (non-receptor); Protein kinase, AGC; Kinase, protein; EC 2.7.11.13; AGC group; PKC family; Eta subfamily

Chromosomal Location of Human Ortholog: 2p21

Cellular Component: Golgi apparatus; cytoskeleton; mitochondrion; perinuclear region of cytoplasm; endoplasmic reticulum; cytoplasm; plasma membrane; nucleus; cytosol

Molecular Function: actin monomer binding; calcium-independent protein kinase C activity; protein serine/threonine kinase activity; protein binding; signal transducer activity; enzyme binding; protein kinase C activity; metal ion binding; enzyme activator activity; ethanol binding; ATP binding; receptor activator activity

Biological Process: nerve growth factor receptor signaling pathway; apoptosis; response to morphine; positive regulation of lipid catabolic process; signal transduction; protein amino acid phosphorylation; positive regulation of MAPKKK cascade; lipopolysaccharide-mediated signaling pathway; cell adhesion; regulation of peptidyl-tyrosine phosphorylation; epidermal growth factor receptor signaling pathway; positive regulation of cytokinesis; platelet activation; positive regulation of I-kappaB kinase/NF-kappaB cascade; fibroblast growth factor receptor signaling pathway; positive regulation of synaptic transmission, GABAergic; positive regulation of insulin secretion; cell cycle; peptidyl-serine phosphorylation; positive regulation of actin filament polymerization; phospholipase C activation; cell division; release of sequestered calcium ion into cytosol; macrophage activation during immune response; innate immune response; blood coagulation
Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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