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PKD2 peptide :: Polycystin 2 / PKD2 Peptide

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Catalog # MBS425723
Unit / Price
  0.1 mg  /  $190 +1 FREE 8GB USB
PKD2 peptide
Product Name

Polycystin 2 / PKD2, Peptide

Popular Item
Also Known As

Polycystin 2 / PKD2 Immunizing Peptide

Product Synonym Names
PKD2; polycystic kidney disease 2 (autosomal dominant); APKD2; MGC138466; MGC138468; PC2; PKD4; polycystin 2; polycystwin; Polycystin 2; Polycystin 2 / PKD2
Product Gene Name
Antibody/Peptide Pairs
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
Sequence Length
968
Sequence
C-ERAKLKRR EVLGR
OMIM
173910
Species Reactivity
Human, Mouse, Rat, Cow
Form/Format
100ug of dried peptide
Preparation and Storage
Shipped at ambient temperature, store at -20 degree C
ISO Certification
Manufactured in an ISO 9001:2015 Certified Laboratory.
Other Notes
Small volumes of PKD2 peptide vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
NCBI/Uniprot data below describe general gene information for PKD2. It may not necessarily be applicable to this product.
NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
98,838 Da
NCBI Official Full Name
polycystin-2
NCBI Official Synonym Full Names
polycystin 2, transient receptor potential cation channel
NCBI Official Symbol
NCBI Official Synonym Symbols
PC2; PKD4; Pc-2; APKD2; TRPP2
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NCBI Protein Information
polycystin-2
UniProt Protein Name
Polycystin-2
UniProt Synonym Protein Names
Autosomal dominant polycystic kidney disease type II protein; Polycystic kidney disease 2 protein; Polycystwin; R48321; Transient receptor potential cation channel subfamily P member 2
Protein Family
UniProt Gene Name
UniProt Entry Name
PKD2_HUMAN
NCBI Summary for PKD2
This gene encodes a member of the polycystin protein family. The encoded protein is a multi-pass membrane protein that functions as a calcium permeable cation channel, and is involved in calcium transport and calcium signaling in renal epithelial cells. This protein interacts with polycystin 1, and they may be partners in a common signaling cascade involved in tubular morphogenesis. Mutations in this gene are associated with autosomal dominant polycystic kidney disease type 2. [provided by RefSeq, Mar 2011]
UniProt Comments for PKD2
PKD2: Involved in fluid-flow mechanosensation by the primary cilium in renal epithelium. PKD1 and PKD2 may function through a common signaling pathway that is necessary for normal tubulogenesis. Acts as a regulator of cilium length, together with PKD1. The dynamic control of cilium length is essential in the regulation of mechanotransductive signaling. The cilium length response creates a negative feedback loop whereby fluid shear-mediated deflection of the primary cilium, which decreases intracellular cAMP, leads to cilium shortening and thus decreases flow-induced signaling. Functions as a calcium permeable cation channel. Defects in PKD2 are the cause of polycystic kidney disease autosomal dominant type 2 (ADPKD2). ADPKD2 is a disorder characterized by progressive formation and enlargement of cysts in both kidneys, typically leading to end-stage renal disease in adult life. Cysts also occurs in the liver and other organs. It represents approximately 15% of the cases of autosomal dominant polycystic kidney disease. ADPKD2 is clinically milder than ADPKD1 but it has a deleterious impact on overall life expectancy. Belongs to the polycystin family. 5 isoforms of the human protein are produced by alternative splicing.

Protein type: Membrane protein, integral; Membrane protein, multi-pass; Channel, cation

Chromosomal Location of Human Ortholog: 4q22.1

Cellular Component: basal cortex; basal plasma membrane; cilium; cytoplasm; cytosol; endoplasmic reticulum; endoplasmic reticulum membrane; filamentous actin; integral to plasma membrane; intercellular junction; lamellipodium; motile primary cilium; nonmotile primary cilium; plasma membrane

Molecular Function: actinin binding; ATPase binding; calcium ion binding; calcium-induced calcium release activity; cytoskeletal protein binding; HLH domain binding; identical protein binding; muscle alpha-actinin binding; phosphoprotein binding; potassium channel activity; protein binding; protein homodimerization activity; receptor binding; voltage-gated calcium channel activity; voltage-gated cation channel activity; voltage-gated ion channel activity; voltage-gated sodium channel activity

Biological Process: calcium ion transport; cell cycle arrest; centrosome duplication; cytoplasmic sequestering of transcription factor; detection of mechanical stimulus; determination of left/right symmetry; embryonic placenta development; G1/S-specific positive regulation of cyclin-dependent protein kinase activity; heart development; heart looping; JAK-STAT cascade; liver development; negative regulation of cell proliferation; neural tube development; positive regulation of inositol-1,4,5-triphosphate receptor activity; positive regulation of nitric oxide biosynthetic process; positive regulation of transcription from RNA polymerase II promoter; regulation of cAMP metabolic process; regulation of cell proliferation; regulation of postsynaptic membrane potential; release of sequestered calcium ion into cytosol; spinal cord development; ureteric bud branching

Disease: Polycystic Kidney Disease 2
Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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