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PLAU cdna clone

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Catalog # MBS1277712
Unit / Price
  0.01 mg Plasmid + 0.2 mL Glycerol-Stock  /  $165 +1 FREE 8GB USB
PLAU cdna clone
Product Name

PLAU, cDNA Clone

Popular Item
Also Known As

PLAU cDNA Clone

Product Gene Name
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
Sequence Length
1296
Sequence
atgagagccc tgctggcgcg cctgcttctc tgcgtcctgg tcgtgagcga ctccaaaggc agcaatgaac ttcatcaagt tccatcgaac tgtgactgtc taaatggagg aacatgtgtg tccaacaagt acttctccaa cattcactgg tgcaactgcc caaagaaatt cggagggcag cactgtgaaa tagataagtc aaaaacctgc tatgagggga atggtcactt ttaccgagga aaggccagca ctgacaccat gggccggccc tgcctgccct ggaactctgc cactgtcctt cagcaaacgt accatgccca cagatctgat gctcttcagc tgggcctggg gaaacataat tactgcagga acccagacaa ccggaggcga ccctggtgct atgtgcaggt gggcctaaag ccgcttgtcc aagagtgcat ggtgcatgac tgcgcagatg gaaaaaagcc ctcctctcct ccagaagaat taaaatttca gtgtggccaa aagactctga ggccccgctt taagattatt gggggagaat tcaccaccat cgagaaccag ccctggtttg cggccatcta caggaggcac cgggggggct ctgtcaccta cgtgtgtgga ggcagcctca tcagcccttg ctgggtgatc agcgccacac actgcttcat tgattaccca aagaaggagg actacatcgt ctacctgggt cgctcaaggc ttaactccaa cacgcaaggg gagatgaagt ttgaggtgga aaacctcatc ctacacaagg actacagcgc tgacacgctt gctcaccaca acgacattgc cttgctgaag atccgttcca aggagggcag gtgtgcgcag ccatcccgga ctatacagac catctgcctg ccctcgatgt ataacgatcc ccagtttggc acaagctgtg agatcactgg ctttggaaaa gagaattcta ccgactatct ctatccggag cagctgaaaa tgactgttgt gaagctgatt tcccaccggg agtgtcagca gccccactac tacggctctg aagtcaccac caaaatgctg tgtgctgctg acccacagtg gaaaacagat tcctgccagg gagactcagg gggacccctc gtctgttccc tccaaggccg catgactttg actggaattg tgagctgggg ccgtggatgt gccctgaagg acaagccagg cgtctacacg agagtctcac acttcttacc ctggatccgc agtcacacca aggaagagaa tggcctggcc ctctga
OMIM
191840
Vector
pENTR223.1
Clone Sequence Report
Provided with product shipment
ISO Certification
Manufactured in an ISO 9001:2008 Certified Laboratory.
Other Notes
Small volumes of PLAU cdna clone vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
NCBI/Uniprot data below describe general gene information for PLAU. It may not necessarily be applicable to this product.
NCBI GI #
NCBI GeneID
NCBI Accession #
UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
46,908 Da
NCBI Official Full Name
Homo sapiens plasminogen activator, urokinase, mRNA
NCBI Official Synonym Full Names
plasminogen activator, urokinase
NCBI Official Symbol
NCBI Official Synonym Symbols
ATF; QPD; UPA; URK; u-PA; BDPLT5
  [Similar Products]
NCBI Protein Information
urokinase-type plasminogen activator
UniProt Protein Name
Urokinase-type plasminogen activator
UniProt Gene Name
UniProt Synonym Gene Names
U-plasminogen activator; uPA  [Similar Products]
UniProt Entry Name
UROK_HUMAN
NCBI Summary for PLAU
This gene encodes a secreted serine protease that converts plasminogen to plasmin. The encoded preproprotein is proteolytically processed to generate A and B polypeptide chains. These chains associate via a single disulfide bond to form the catalytically inactive high molecular weight urokinase-type plasminogen activator (HMW-uPA). HMW-uPA can be further processed into the catalytically active low molecular weight urokinase-type plasminogen activator (LMW-uPA). This low molecular weight form does not bind to the urokinase-type plasminogen activator receptor. Mutations in this gene may be associated with Quebec platelet disorder and late-onset Alzheimer's disease. Alternative splicing results in multiple transcript variants, at least one of which encodes an isoform that is proteolytically processed. [provided by RefSeq, Jan 2016]
UniProt Comments for PLAU
uPA: Specifically cleave the zymogen plasminogen to form the active enzyme plasmin. Defects in PLAU are the cause of Quebec platelet disorder (QPD). QPD is an autosomal dominant bleeding disorder due to a gain-of-function defect in fibrinolysis. Although affected individuals do not exhibit systemic fibrinolysis, they show delayed onset bleeding after challenge, such as surgery. The hallmark of the disorder is markedly increased PLAU levels within platelets, which causes intraplatelet plasmin generation and secondary degradation of alpha-granule proteins. Belongs to the peptidase S1 family. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Secreted; Secreted, signal peptide; Protease; Motility/polarity/chemotaxis; EC 3.4.21.73

Chromosomal Location of Human Ortholog: 10q22.2

Cellular Component: cell surface; extracellular region; extracellular space; focal adhesion; plasma membrane

Molecular Function: protein binding; serine-type endopeptidase activity

Biological Process: chemotaxis; fibrinolysis; positive regulation of cell migration; regulation of cell adhesion mediated by integrin; regulation of receptor activity; regulation of smooth muscle cell migration; signal transduction

Disease: Alzheimer Disease; Quebec Platelet Disorder
Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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